How to effectively relieve pain and reduce adverse reactions after spinal surgery has become an urgent problem to be solved. To solve this problem, the study evaluated the efficacy of acetaminophen mannitol injection in postoperative analgesia after spinal surgery through the use of sufentanil, pain rating and adverse reaction statistics. The results showed that the probability of adverse reactions in the experimental group was 9.86%, while the probability of adverse reactions in the control group was 15.07%. It is proved that acetaminophen mannitol injection not only has significant analgesic effect, but also can greatly shorten the postoperative recovery time of spinal surgery patients, and effectively reduce the risk of various complications. It provides a safer and more effective analgesic program for the postoperative recovery of spinal surgery patients. It is of great practical significance to improve the quality of life of patients after operation and reduce their physical and mental burden.  

Jinfeng Wang, Bowen Chen, Xingyu Chen, Weilian Wang, Jiapeng Dan, Kun Zhang. Efficacy and Safety of Acetaminophen Mannitol Injection in Postoperative Analgesia in Spinal Surgery. International Journal of Frontiers in Medicine (2025), Vol. 7, Issue 1: 97-102. https://doi.org/10.25236/IJFM.2025.070116.

[1] Wang Yin, Wen Chuanyun, Man Jinyu. Comparison of the effects of hydromorphone and sufentanil in postoperative analgesia and delirium control in elderly orthopedic patients[J]. Chinese and Foreign Medical Treatment, 2024, 43(34): 21-24+37.

[2] Zhang Tingyu, Zhang Wei, Xu Xiaqing, et al. Analysis of 78 cases of adverse drug reactions of propacetamol hydrochloride injection for postoperative analgesia[J]. Journal of Henan Surgery, 2024, 30(06): 121-123. 

[3] Sun Q, Zhang C, Liu S, et al. Efficacy of erector spinae plane block for postoperative analgesia lumbar surgery: a systematic review and meta-analysis[J]. BMC anesthesiology, 2023, 23(1): 54-55.

[4] Zhang Z, Zhu R L, Yue L, et al. Bilateral ultrasound-guided erector spinae plane block versus wound infiltration for postoperative analgesia in lumbar spinal fusion surgery: a randomized controlled trial[J]. European Spine Journal, 2023, 32(1): 301-312.

[5] Mirkheshti A, Raji P, Komlakh K, et al. The efficacy of ultrasound-guided erector spinae plane block (ESPB) versus freehand ESPB in postoperative pain management after lumbar spinal fusion surgery: a randomized, non-inferiority trial[J]. European Spine Journal, 2024, 33(3): 1081-1088.

[6] Jelodar A G, Makrani N F, Shafizad M, et al. Comparison of dexmedetomidine and ketamine in adjuvant with morphine for postoperative pain management following lumbar fusion surgery[J]. Interdisciplinary Neurosurgery, 2023, 33(1): 101767-101771.

[7] Mahmoud A M, Ragab S G, Shawky M A, et al. The efficacy of erector spinae plane block compared with intrathecal morphine in postoperative analgesia in patients undergoing lumbar spine surgery: a double-blind prospective comparative study[J]. Pain Physician, 2023, 26(2): 149.

[8] Zhu Qingxin, Tian Lei, Wen Kaixuan. Effects of dexmedetomidine combined with different doses of sufentanil on postoperative analgesia in patients undergoing spinal surgery[J]. Chinese Health Care, 2024, 42(14): 39-42.

[9] Xiang Yun, Xu Qiaomin, Ai Mengting. Effects of esketamine combined with sufentanil on perioperative indicators and postoperative analgesic and sedative effects of spinal surgery[J]. Chinese Journal of Drugs and Clinics, 2024, 24(11): 696-699.

[10] Zhou Y, Yuan P, Xing Q, et al. Efficacy of postoperative analgesia with intravenous paracetamol and mannitol injection, combined with thoracic paravertebral nerve block in post video-assisted thoracoscopic surgery pain: a prospective, randomized, double-blind controlled trial[J]. BMC anesthesiology, 2024, 24(1): 14-15. 

[11] Lu X, Zhou J, Li X, et al. Efficacy of intravenous paracetamol and mannitol in managing chronic post-thoracotomy pain in patients with lung cancer: Study protocol for a single center prospective randomized double-blind controlled trial[J]. medRxiv, 2024: 2024, 27(8): 24312675-24312677.

[12] Hadavi S M R, Panah A, Shamohammadi S, et al. The Prophylactic Effect of Acetaminophen and Caffeine on Post Dural Puncture Headache after Spinal Anesthesia for Cesarean Section: A Randomized Double-Blind Clinical Trial[J]. Iranian Journal of Medical Sciences, 2024, 49(9): 573-575.

[13] Wu Ruiyang, Han Linglong. Effects of esketamine combined with sufentanil postoperative patient-controlled analgesia on pain, stress hormones and immune function in patients undergoing spinal surgery[J]. Chinese Journal of Rational Drug Use, 2024, 21(07): 81-88.