International Journal of Frontiers in Medicine, 2025, 7(2); doi: 10.25236/IJFM.2025.070204.
Gao Shanshan1,3,4, Chen Wenyu2,3,4, Feng Chonglian2,3,4, Cao Lihui1,3,4, Pan Weiyu5, Nie Zhaoyuan2,3,4
1Department of Pharmacy,The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
2Department of Traditional Chinese Medicine,The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China
3Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangzhou, 510150, China
4Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, 510150, China
5Department of Endocrinology,The Hospital of Integrated Traditional Chinese and Western Medicine of Guangdong Province, Foshan, 528200, China
Based on clinical information system,network pharmacology and data mining technology were used to explore the drug use rules and potential mechanism of Guangdong famous doctor of traditional Chinese medicine Feng Chonglian in the treatment of male infertility. Cases diagnosed as "male infertility" or "infertility" in the hospital information systerm (HIS) from January 2020 to December 2022 were extracted and imported into Excel database for analysis by data mining and network pharmacology. The study found that 2,531 male infertility patients received treatment with Chinese herbal slices,using 299 kinds of Chinese herbs, among which 36 were high-frequency herbs.Cluster analysis identified five effective clusters; association analysis yielded 13 association rules,ultimately determining "dioscoreae rhizoma,moutan cortex,poria cocos,alismatis rhizoma,ligustri lucidi fructus" as the core prescription for treating male infertility.This prescription contains 62 active ingredients,involves 181 gene targets, 1,385 disease targets,and 99 intersection targets between the core prescription and the disease.Through PPI network analysis,GO analysis,and KEGG pathway enrichment analysis,it was concluded that quercetin,kaempferol and luteolin might be the key active ingredients for the treatment of male infertility. Guangdong famous doctor of traditional Chinese medicine Feng Chonglian in the treatment of male infertility to tonifying kidney and essence, invigorating spleen and liver,promoting blood circulation as the main ideas,according to different symptoms of patients to carry out syndrome differentiation treatment,the use of Liuwei Dihuang pill as the basic prescription clinical addition and reduction effect is accurate,rational, there is evidence to follow.
Infertility, Network pharmacology, data mining, Medication rule, Liuwei Dihuang pill
Gao Shanshan, Chen Wenyu, Feng Chonglian, Cao Lihui, Pan Weiyu, Nie Zhaoyuan.Exploring the Patterns and Mechanisms of Treatment for Male Infertility by the Famous Lingnan Physician Feng Chonglian Based on Data Mining and Network Pharmacology. International Journal of Frontiers in Medicine(2025), Vol. 7, Issue 2: 18-29. https://doi.org/10.25236/IJFM.2025.070204.
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