Knee varus can cause pain during walking in the knee joint, and the joint's mobility is also affected, which can easily lead to knee osteoarthritis. This study aims to explore the current status and trends worldwide regarding the diagnosis and treatment of knee varus after total hip arthroplasty (THA). Research on knee varus following total hip arthroplasty (THA) published between January 1, 2014, and January 3, 2025, was collected from the Web of Science Science Citation Index Expanded (WOS). Bibliometric techniques were employed to examine and categorize the source data. For visualization purposes, VOS viewer version 1.6.18 software was used to conduct analyses on coauthorship, cooccurrence, bibliographic coupling, and cocitation, as well as to assess the overall research trends related to knee varus after THA in recent years. 440 relevant articles in all were gathered. Both the proportional research interest and the quantity of papers produced each year are rising globally. A logistic growth model can be fitted using the cumulative publication number of studies on knee varus following THA: f(x) = a/(1 + eb cx). With the highest citation counts, hindex, and total link strength (TLS), the US has made the biggest contribution to international research. "Knee Surgery Sports Traumatology Arthroscopy" publishes the majority of the studies. The university that has contributed the most is Boston University. Mechanism studies, tissue engineering, clinical investigations, and mechanical studies are the four categories into which the research falls. Clinical research receives comparatively little funding. Based on current global trends, the number of articles concerning knee varus after THA is expected to continue to increase in the coming years. In this field, the United States is the largest contributor. Notably, recent hotspots include “pathogenesis,” “alignment of limbs,” “arthroplasty,” and “total hip arthroplasty.” Therefore, there will likely be more research on tissue engineering for knee varus after THA, which may inspire new clinical treatment methods for knee varus.

Jiayu Liu, Ji Wen, Tao Wu, Pengfei Han, Xiaobo Shi, Yuan Li.Global Trends in the Diagnosis and Treatment of Knee Valgus after THA: A Bibliometric and Visualized Study. International Journal of Frontiers in Medicine(2025), Vol. 7, Issue 2: 46-56. https://doi.org/10.25236/IJFM.2025.070208.

[1] Sun JY, Ma HY, Shen JM, Du YQ, Dong Y, Zhang YC, Zhou YG, Wang Y. Factors influencing knee valgus alignment in Crowe type IV hip dysplasia after total hip arthroplasty. J Orthop Traumatol. 2021 Oct 16;22(1):41. doi: 10.1186/s1019502100601y. PMID: 34655357; PMCID: PMC8520551.

[2] Wang Z, Zhou Q, Xie F. Biomechanical experimental study on different osteotomy angles of the femoral distal end in knee valgus osteotomy [J]. Journal of Surgical Anatomy, 2024, 33(05):399403.

[3] Song YM. The impact of the degree of correction of knee valgus on clinical efficacy after total knee arthroplasty [J]. Jilin Medicine, 2022, 43(10):26662669.

[4] Liu JZ, Huan D, Zhang CH, et al. Total knee arthroplasty for knee valgus deformity: a report of 19 cases [J]. Chinese Journal of Traditional Chinese Medicine and Traumatology, 2022, 30(1):6569.

[5] Thöne P, Gruber MS, Kindermann H, Gussner W, Sadoghi P, Ortmaier R. The influence of stem design on contralateral knee valgus in total hip arthroplasty: A retrospective comparative analysis of 2953 cases. Journal of Clinical Medicine, 2023 Oct 21;12(20):6662. doi: 10.3390/jcm12206662. PMID: 37892800; PMCID: PMC10607773.

[6] Sepriano A, RomanBlas JA, Little RD, PimentelSantos F, Arribas JM, Largo R, et al. DXA in the assessment of subchondral bone mineral density in knee osteoarthritis  A semistandardized protocol after systematic review. Semin Arthritis Rheum. 2015;45(3):27583.

[7] Wen PF, Liu R, Wang J, Wang YK, Song W, Zhang YM. Bibliometric insights from publications on subchondral bone research in osteoarthritis. Front Physiol. 2022;13:13.

[8] Swain S, Sarmanova A, Mallen C, Kuo CF, Coupland C, Doherty M, et al. Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis Cartilage. 2020;28(6):792801.

[9] Xing D, Zhao Y, Dong SJ, Lin JH. Global research trends in stem cells for osteoarthritis: a bibliometric and visualized study. Int J Rheum Dis. 2018;21(7):137284.

[10] Luo ZH, Gong SD, Wei QS, et al. Analysis of the research status and trends of denosumab and bisphosphonates in the treatment of osteoporotic fractures based on bibliometrics and visualization technology [J]. Chinese Hospital Pharmacy Journal, 2021, 41(06):589595. DOI:10.13286/j.10015213.2021.06.06.

[11] Fatima I, Hassan D, Perveen W, Ali MA, Bhatti ZM, Ashraf A. Kinesiophobia and Outcomes of Lower Extremity Exercise Regime in Subjects with Knee Osteoarthritis: A Case Series. Pak J Med Health Sci. 2021;15(10):26312.

[12] Lu B, Liu ZT, Kong FL, An HP, Hou XL, Fan GF, et al. A bibliometrics analysis and visualization of osteoimmunology on osteoarthritis studies. Am J Transl Res. 2022;14(6):426077.

[13] Zhang J, Lin MY, Huang YR, Wang YP, Huang TJ, Wu ZL, et al. Harnessing hyaluronic acid for the treatment of osteoarthritis: A bibliometric analysis. Front Bioeng Biotechnol. 2022;10:17.

[14] Liu PD, Zhang C, Lu Z, Feng JF, Xu WJ, Yang ZQ. Global research status and trends of UKA for knee osteoarthritis: a bibliometric analysis. Arthroplasty. 2020;2(1):9.

[15] Wang K, Xing D, Dong SJ, Lin JH. The global state of research in nonsurgical treatment of knee osteoarthritis: a bibliometric and visualized study. BMC Musculoskeletal Disorders. 2019;20(1):10

[16] Yang JY, Jiang T, Xu GM, Liu WA. Bibliometrics Analysis and Visualization of Sarcopenia Associated with Osteoporosis from 2000 to 2022. J Pain Res. 2023;16:82137.

[17] Zhang SY, Wang YW, Zhou M, Jia S, Liu Y, Zhang XH, et al. A bibliometric analysis of traditional Chinese nonpharmacological therapies in the treatment of knee osteoarthritis from 2012 to 2022. Front Neurosci. 2023;17:13.

[18] Zhou TP, Xu YH, Xu WD. Emerging research trends and foci of studies on the meniscus: A bibliometric analysis. Journal of Orthopaedic Surgery. 2020;28(3):7.