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Academic Journal of Medicine & Health Sciences, 2025, 6(3); doi: 10.25236/AJMHS.2025.060302.

Main problems of clinical use of cefotaxime sodium for injection in China and its countermeasures

Author(s)

Haishi Yu, Juan Yu, Jieli Guang, Hongxi Li, Jinrong Bai, Yujiao Gao, Ping Chang, Yan Feng, Fengyuan Li

Corresponding Author:
Jieli Guang
Affiliation(s)

Yunnan Normal University Hospital, Yunnan Normal University, Kunming, China

Abstract

This paper provides an in-depth discussion of the major problems in the clinical use of cefotaxime sodium for injection in China. Analysis of the relevant literature reveals that the need for skin testing before the use of cefotaxime sodium is controversial, and that inappropriate dosage and solvent use are the main problems in the current application of this drug in China. In view of these problems, this paper puts forward corresponding countermeasures and suggestions to solve them, including strengthening the training of medical personnel, optimising the dosage regimen, and standardising the choice of solvents. By revealing the main problems of clinical use of cefotaxime sodium for injection in China and exploring the countermeasures and suggestions, this paper will provide research results for optimising and improving China's antimicrobial drug management policy and improving the health of the whole population, thus contributing to the construction of "Healthy China".

Keywords

cefotaxime sodium for injection; clinical use; skin test controversy; dosage; solvent choice

Cite This Paper

Haishi Yu, Juan Yu, Jieli Guang, Hongxi Li, Jinrong Bai, Yujiao Gao, Ping Chang, Yan Feng, Fengyuan Li. Main problems of clinical use of cefotaxime sodium for injection in China and its countermeasures. Academic Journal of Medicine & Health Sciences(2025), Vol. 6, Issue 3: 8-13. https://doi.org/10.25236/AJMHS.2025.060302.

References

[1] Carmine AA, Brogden RN, Heel RC, Speight TM, Avery GS. Cefotaxime. A review of its antibacterial activity, pharmacological properties and therapeutic use[J]. Drugs. 1983,5(3):223-89.

[2] Wang Yun, Wang Qiang, Li Xianghe, etc. . Quality evaluation of cefotaxime sodium for injection [J] . Chinese Journal of antibiotics, 2023,48(03) : 276-284.

[3] Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men[J]. Clin Infect Dis. 1998 Jan;26(1):1-10; quiz 11-2.

[4] Chen Xiangjun, Zhou Yi, Meng Juan, et al. Standardized management of skin test of cephalosporins in medical institutions [J] . Chinese Journal of antibiotics, 2021,46(12): 1133-1137.

[5] General Office of the National Health Commission. Circular of the General Office of the National Health Commission on the Issuance of Guidelines for Skin Tests of β-lactam Antimicrobial Drugs (2021 Edition). State Health Office Medical Letter [2021] No. 188. 13 April 2021

[6] He Miao, Zhang Haixia, Zhao Xin, etc. Investigation on the implementation of “Skin testing guidelines for β-lactam antibiotics (2021 edition)” in some medical institutions [J] . Chinese Journal of Clinical Pharmacy, 2024,000(1): 5. DOI: 10.19577/J. 1007-4406.2024.01.003.

[7] Torres J M ,Adkinson F N ,Caubet J , et al. Controversies in Drug Allergy: Beta-Lactam Hypersensitivity Testing[J].The Journal of Allergy and Clinical Immunology: In Practice,2019,7(1):40-45.

[8] Yang Linqing, Yang Li, Luo Yanni, etc. . Summary of best evidence from skin trials of β-lactam antibiotics [J]. Journal of Advanced Nursing Education, 2024,39(01): 65-70. DOI: 10.16821/J. CNKI. HSJX.2024.01.012.

[9] Huo Ting, Wang Yue. Exploring the content of duty of care from the case of cephalosporin antibiotic allergy [J]. China Forensic Science, 2022, (02): 88-93.

[10] General Office of the National Health and Family Planning Commission, Office of the State Administration of Traditional Chinese Medicine, Bureau of Drugs and Materials of the Ministry of Health, General Logistics Department of the People's Liberation Army. Notice on the issuance of the Guiding Principles for Clinical Application of Antibacterial Drugs (2015 Edition). State Health Office Medical Development [2015] No. 43. 24th July 2015

[11] Chen Xinqian, JIN Youyu, TANG Guang. New Pharmacology (18th Edition) [M]. Beijing: People's Health Publishing House,2018

[12] Liu Meichun, Ning Yaru, Liu Yingchun. Cefotaxime sodium-induced anaphylaxis: a case report [J]. China Medical Review, 2009,6(10): 163-164.

[13] Lv Wenhan. Analysis of 2 cases of adverse drug reactions induced by intravenous cefotaxime sodium [J] . Chinese community physicians, 2012,28(02): 18.

[14] Zhang Ye, Xu Feng, Wu Weifeng. Study on stability and antibacterial activity of cefotaxime sodium in different injections [J] . Chinese medical journal, 2014,16(06) : 1097-1098.

[15] Xue Zhimin, Wang Hui. Safety analysis of Cefotaxime for injection in pediatrics [J] . Chinese Journal of Pharmacology and clinical medicine, 2021,21(17) : 3027-3029.

[16] Institute of Hospital Management, National Health and Wellness Commission. Report on Quality Management of Antimicrobial Drug Clinical Use (2020) [R]. Beijing: People's Health Publishing House, 2021: 56-59.

[17] Zhu Xiaoping, Gong Meifang, Shi Yan. Practical application of transfusion safety management monitoring network and high-risk early warning system [J] . China Hospital, 2013,17(06) : 14-15.