This study investigates the integrative use of Danzhi Xiaoyao San (DZXYS) combined with antithyroid drugs (ATDs) for hyperthyroidism, a clinical syndrome characterized by systemic hypermetabolism and excitability due to excessive thyroid hormone secretion. In Traditional Chinese Medicine (TCM), hyperthyroidism is categorized as Ying disease , attributed to emotional disharmony causing Liver Qi stagnation , which progresses to Liver Fire hyperactivity and thyroid enlargement. Modified DZXYS—a formula targeting Qi regulation, heat clearance, and blood nourishment—is frequently employed. Conventional therapies, including ATDs (e.g., methimazole, propylthiouracil), surgery, and radioiodine, face limitations such as adverse effects and relapse. The TCM-Western integrative approach synergizes syndrome differentiation with ATDs, enhancing therapeutic efficacy, minimizing side effects, and leveraging holistic and targeted mechanisms. This strategy exemplifies optimized clinical outcomes through complementary modalities, warranting further exploration of its molecular foundations and long-term benefits.

Yangyang He, Zongliang Song. Current Research Status of Danzhi Xiaoyao San Combined with Antithyroid Drugs in the Treatment of Hyperthyroidism with Liver Qi Stagnation and Heat Transformation. Academic Journal of Medicine & Health Sciences(2025), Vol. 6, Issue 4: 21-26. https://doi.org/10.25236/AJMHS.2025.060404.

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