Academic Journal of Medicine & Health Sciences, 2025, 6(5); doi: 10.25236/AJMHS.2025.060510.
Jiaguo Liang1, Qishen Xian1, Ting Jiang1, Min Wei1, Dongnian Wu1, Duorong Wang1, Wenjin Huang1, Chaoyuan Yang1, Zukang Deng1, Shuqiu Zhang1, Qijun Long2,3
1College of Clinical Medical, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China
2College of Humanities and Management, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China
3College of Innovation and Entrepreneurship, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, China
This study explored the impact of subchronic aluminum exposure on brain α-secretase and γ-secretase activities in AD model mice. Thirty Kunming mice were randomized into a normal group, a low-dose group (0.3 mL of 50 mg/kg aluminum maltolate, i.p.), and a high-dose group (0.45 mL of 75 mg/kg aluminum maltolate, i.p.), with daily treatments for 30 days. Spatial memory was assessed using the Y-maze water labyrinth[1]. Brain homogenate enzyme activities and serum biochemical markers (urea nitrogen, TC, TG) were measured via standard protocols. Results showed increased aluminum exposure significantly prolonged swimming latency and path length in the water labyrinth (P < 0.05, one-way ANOVA), coupled with reduced α/γ-secretase activities compared to the normal group. Aluminum maltolate (Al(mal)₃) exposure induced AD-like symptoms, including cognitive dysfunction and neuronal damage, as reflected by impaired spatial learning in the Y-maze[2].In conclusion, subchronic aluminum exposure contributes to AD pathogenesis by dysregulating α/γ-secretase, influencing Aβ metabolism. These findings provide experimental basis for preventing aluminum-related neurodegenerative diseases.
Alzheimer's Disease; Subchronic Aluminum Exposure; Α-Secretase Activity; Γ-Secretase Activity
Jiaguo Liang, Qishen Xian, Ting Jiang, Min Wei, Dongnian Wu, Duorong Wang, Wenjin Huang, Chaoyuan Yang, Zukang Deng, Shuqiu Zhang, Qijun Long. Study on the Effects of Subchronic Aluminum Exposure on the Activities of Brain α-Secretase and γ-Secretase in Alzheimer's Disease Model Mice. Academic Journal of Medicine & Health Sciences (2025), Vol. 6, Issue 5: 63-67. https://doi.org/10.25236/AJMHS.2025.060510.
[1] Wei Junhong. Study on the role of PP2A and Tau protein in cognitive impairment induced by aluminum maltol in C57BL/6 mice [D]. Youjiang Medical University for Nationalities, 2023. DOI: 10.27908/d.cnki.gymzy.2023.000300.
[2] Zhang Shuqiu, Huang Qiuyan, Li Chaogan, et al. The improvement effect of zinc and Haierfu oral liquid on memory impairment caused by lead poisoning in mice was determined by Y-maze water maze [J]. Chinese Journal of Medical Metallurgy Industry, 2006, (05): 546-548.
[3] Yang Lichang. Research progress on the pathogenesis, early intervention and treatment of Alzheimer's disease [J]. Progress in Biomedical Engineering, 2024, 45(01): 14-20.
[4] Cao Yun. Research progress on the impact of aluminum on human health and the amount and determination of aluminum added in flour products [J]. Henan Journal of Preventive Medicine, 2015, 26(05): 353-357. DOI: 10.13515/j.cnki.hnjpm.1006-8414.2015.05.009.
[5] Li Chenyu, Jia Yunjing, Gan Juefang, et al. The effect of chronic aluminum poisoning on the memory function of rats [J]. Journal of Nanchang University (Medical Edition), 2024, 64(01): 1-5+31. DOI: 10.13764/j.cnki.ncdm.2024.01.001.
[6] Yu Zhen, Wang Kai, Xu Jiachun, et al. Research progress of traditional Chinese medicine in preventing and treating Alzheimer's disease based on the mechanism of Aβ generation and aggregation [J]. Chinese Journal of Gerontology, 2022, 42(15): 3858-3862.
[7] Wang Linping, Wang Jing, Shi Yingtao, et al. The effect of aluminum on Aβ accumulation in rat brain and the expression changes of various subtypes of α-secretase [J]. Journal of Toxicology, 2013, 27(05): 379-381+386. DOI: 10.16421/j.cnki.1002-3127.2013.05.019.