This study was designed to elucidate the pivotal role and potential mechanisms of chronic low-grade inflammation in acne pathogenesis, thereby offering new perspectives for clinical management.A comprehensive review of recent literature on acne and inflammation was conducted, with emphasis on the involvement and interplay of inflammatory cytokines, immune signaling pathways, sebaceous gland function, and cutaneous microecological imbalance.Patients with acne frequently exhibit elevated circulating and local levels of key pro-inflammatory mediators, including interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP). These alterations form a pathological network in which localized skin lesions and systemic inflammatory responses mutually reinforce one another, thereby promoting disease persistence and progression. Chronic low-grade inflammation is a central driver throughout the entire course of acne, contributing to its chronicity and therapeutic resistance. Related inflammatory and metabolic biomarkers hold promise as auxiliary indicators for clinical diagnosis, disease stratification, and therapeutic efficacy evaluation.

Yaoyu Qi, Shufan Qin, Ke Liu, Huiling Jing. Research Progress on Chronic Low-Grade Inflammation and Acne. International Journal of Frontiers in Medicine (2025), Vol. 7, Issue 4: 39-44. https://doi.org/10.25236/IJFM.2025.070406.

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