Association between APOE Gene Polymorphisms and Hyperuricemia in a County Population of Guangxi, China

<p>Chaofan Xie<sup>1,2</sup>, Bin Wang<sup>1,2</sup>, Moqi Zhang<sup>1,2</sup>, Yuan Yang<sup>1,2</sup>, Ying Huang<sup>1,2</sup>, Yiyang Liu<sup>1,2</sup>, Liang Cao<sup>1,3</sup>, Jiansheng Cai<sup>1,2</sup>, Zhiyong Zhang<sup>1,2</sup>, You Li<sup>1,2</sup></p>

doi:10.25236/IJFM.2025.070412

International Journal of Frontiers in Medicine, 2025, 7(4); doi: 10.25236/IJFM.2025.070412.

Association between APOE Gene Polymorphisms and Hyperuricemia in a County Population of Guangxi, China

Author(s)

Chaofan Xie^1,2, Bin Wang^1,2, Moqi Zhang^1,2, Yuan Yang^1,2, Ying Huang^1,2, Yiyang Liu^1,2, Liang Cao^1,3, Jiansheng Cai^1,2, Zhiyong Zhang^1,2, You Li^1,2

Corresponding Author:

Zhiyong Zhang

Affiliation(s)

¹Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin, 541199, China

²Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care (Guilin Medical University), Guilin, 541199, China

³Department of Experimental Teaching Center, School of Public Health, Guilin Medical University, Guilin, 541199, China

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Abstract

This study aims to explore the relationship between apolipoprotein E (APOE) gene polymorphisms and the risk of hyperuricemia (HUA), to provide a theoretical basis for further investigations into the genetic mechanisms and prevention and treatment of this disease. This study included 362 subjects in the hyperuricemic and 362 subjects in the healthy control group, testing for APOE gene polymorphisms (rs429358, rs7259620 and rs405509). Logistic regression was used to analyze the relationships between APOE gene SNPs and other risk factors and hyperuricemia. The distributions of the APOE gene alleles rs429358, rs7259620, and rs405509 were significantly different between the hyperuricemic group and the healthy control group (P<0.05). In terms of genotype distribution, only the rs7259620 locus was significantly different (P<0.05). Logistic regression analysis using codominant, recessive, dominant and overdominant models did not reveal a significant association between APOE gene polymorphism and hyperuricemia. No significant multiplicative or additive interaction effects between SNP loci and environmental factors were observed in the occurrence of hyperuricemia. BMI (23-27.5 kg/m2) and triglyceride (TG) may be protective factors against HUA, whereas smoking, diastolic blood pressure (DBP), and low-density lipoprotein cholesterol (LDL-C) may be risk factors for HUA. The polymorphisms of the APOE genes rs429358, rs7259620, and rs405509 are not directly associated with susceptibility to hyperuricemia, and gene-environment interaction analysis did not reveal a significant effect on the risk of developing hyperuricemia.

Keywords

Hyperuricemia; APOE; Polymorphism; Allele; Influencing Factor

Cite This Paper

Chaofan Xie, Bin Wang, Moqi Zhang, Yuan Yang, Ying Huang, Yiyang Liu, Liang Cao, Jiansheng Cai, Zhiyong Zhang, You Li. Association between APOE Gene Polymorphisms and Hyperuricemia in a County Population of Guangxi, China. International Journal of Frontiers in Medicine (2025), Vol. 7, Issue 4: 94-105. https://doi.org/10.25236/IJFM.2025.070412.

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