The gut bone axis, as a key regulatory network connecting the gut and skeletal system, plays an important regulatory role in chondrocyte differentiation and maintenance of hip joint cartilage development homeostasis. Its morphological polarity is a core feature of cell and tissue spatial structure and molecular distribution. The stable development of hip cartilage depends on the orderly differentiation of chondrocytes. Abnormal differentiation can induce congenital hip dysplasia, hip osteoarthritis, and other diseases. In recent years, the role of morphological polarity in regulating cellular function has gradually been focused on, but the mechanism by which gut bone axis morphological polarity mediates chondrocyte differentiation and maintains hip joint cartilage homeostasis has not been fully elucidated. This article systematically reviews the biological characteristics of the polarity of the gut bone axis morphology, its regulatory effects on chondrocyte differentiation, key signaling pathway mechanisms, and its association with the stable development of hip joint cartilage. It summarizes the shortcomings of existing research and looks forward to future directions, providing theoretical references for basic research and clinical targeted prevention and treatment of hip joint related diseases.

Zimu Ma, Hanyuan Zhang, Jiasifan Li. Research Progress on the Polarity of Gut Bone Axis Morphology, Chondrocyte Differentiation, and Stable Development of Hip Joint Cartilage. Academic Journal of Medicine & Health Sciences (2026), Vol. 7, Issue 2: 83-89. https://doi.org/10.25236/AJMHS.2026.070212.

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