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The Frontiers of Society, Science and Technology, 2020, 2(11); doi: 10.25236/FSST.2020.021109.

An Overview of Sequence Logo Technique and Potential Application Direction


Zhanlin Dong

Corresponding Author:
Zhanlin Dong

Tianjin University School of Pharmaceutical Science and Technology, Tianjin 300072, China

E-mail: [email protected]


As an important and useful technique in the field of bioinformatics, sequence logo was firstly invented by Thomas D. Schneider and R. Michael Stephens in 1990, offering an effective method to visualize the information content at each position in the sequence motif of nucleic acid or protein. In this article, the feature and principle of sequence logo are explained on a biological and statistical level. The specific operation steps to construct sequence logo are introduced. After that, in order to introduce the actual application of the technique, CodonLogo is raised as an instance that applies sequence logo to analyze codon sequence. In the end, a potential application direction aimed to SARS-CoV-2, the pathogen of COVID-19, is anticipated, covering virus genome study and important proteins (pp1ab, nsp1 to nsp16, RdRp, spike proteins) study.


Sequence logo technique, Biological and statistical level, Codonlogo

Cite This Paper

Zhanlin Dong. An Overview of Sequence Logo Technique and Potential Application Direction. The Frontiers of Society, Science and Technology (2020) Vol. 2 Issue 11: 51-57. https://doi.org/10.25236/FSST.2020.021109.


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