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International Journal of Frontiers in Medicine, 2020, 2(3); doi: 10.25236/IJFM.2020.020303.

Association Between Circulating Vitamin D Concentration and early AMD in Shanghai Public Institution Population

Author(s)

Jing Wang, Xiaolong Yang and Tingli Chen*

Corresponding Author:
Tingli Chen*
Affiliation(s)

Department of Ophthalmology, East China sanatorium, Wuxi 214063, Jiangsu Province, China
*Corresponding author

Abstract

To explore the relationship between serum 25-hydroxyvitamin D and early AMD. Methods. This study involved a total of 3,352 subjects older than 45 years who participated in physical examination in East China sanatorium from January to September in 2019.All participants underwent fundus photographs, evaluation of blood 1-25-hydroxyvitamin D levels and comprehensive physical examination.The t-test,variance analysis and logistic regression was used to access the date in statistical way by using SPSS 25.0 statistical software. Results. The incidence of AMD in population who older than 45 years was 10.35%. The incidence of AMD Levels of serum vitamin D were negatively correlated with early AMD.The odds ratio (OR) and 95% confidence interval for early AMD among subjects in the lowest vs highest quintile of serum vitamin D was 1.48(95% CI,1.07-2.12). 25-VD, gender,age, hypertension, smoking were independent risk factors of AMD. Conclusion.This study shows that vitamin D may have a protective effect on early AMD.Further studies are needed to confirm their association.

Keywords

vitamin D, early age-related macular degeneration, shanghai

Cite This Paper

Jing Wang, Xiaolong Yang and Tingli Chen. Association Between Circulating Vitamin D Concentration and early AMD in Shanghai Public Institution Population. International Journal of Frontiers in Medicine (2020), Vol. 2, Issue 3: 16-26. https://doi.org/10.25236/IJFM.2020.020303.

References

[1] Zou M, Zhang Y, Chen A, Young CA, Li Y, Zheng D, Jin G. Variations and trends in global disease burden of age-related macular degeneration: 1990-2017. Acta Ophthalmol 2020.
[2] Erke MG, Bertelsen G, Peto T, Sjolie AK, Lindekleiv H, Njolstad I. Prevalence of age-related macular degeneration in elderly Caucasians: the Tromso Eye Study. Ophthalmology 2012, 119 (9): 1737-1743.
[3] Colijn JM, Buitendijk GHS, Prokofyeva E, Alves D, Cachulo ML, Khawaja AP, Cougnard-Gregoire A, Merle BMJ, Korb C, Erke MG et al. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology 2017, 124 (12): 1753-1763.
[4] Kawasaki R, Yasuda M, Song SJ, Chen SJ, Jonas JB, Wang JJ, Mitchell P, Wong TY. The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis. Ophthalmology 2010, 117 (5): 921-927.
[5] McKay GJ, Young IS, McGinty A, Bentham GC, Chakravarthy U, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F et al. Associations between Serum Vitamin D and Genetic Variants in Vitamin D Pathways and Age-Related Macular Degeneration in the European Eye Study. Ophthalmology 2017, 124 (1): 90-96.
[6] Merle BMJ, Silver RE, Rosner B, Seddon JM. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci 2017, 58 (11): 4569-4578.
[7] Parekh N, Chappell RJ, Millen AE, Albert DM, Mares JA. Association between vitamin D and age-related macular degeneration in the Third National Health and Nutrition Examination Survey, 1988 through 1994. Arch Ophthalmol 2007, 125 (5): 661-669.
[8] Annweiler C, Drouet M, Duval GT, Pare PY, Leruez S, Dinomais M, Milea D. Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. Maturitas 2016, 88: 101-112.
[9] Kim EC, Han K, Jee D. Inverse relationship between high blood 25-hydroxyvitamin D and late stage of age-related macular degeneration in a representative Korean population. Invest Ophthalmol Vis Sci 2014, 55 (8): 4823-4831.
[10] Liu Y, Chen L, Zhi C, Shen M, Sun W, Miao D, Yuan X. 1,25(OH)2D3 Deficiency Induce Colon Inflammation via Secretion of Senescence-Associated Inflammatory Cytokines. PLoS One 2016, 11 (1): e0146426.
[11] Lee V, Rekhi E, Hoh Kam J, Jeffery G. Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function. Neurobiol Aging 2012, 33 (10): 2382-2389.
[12] Uberti F, Lattuada D, Morsanuto V, Nava U, Bolis G, Vacca G, Squarzanti DF, Cisari C, Molinari C. Vitamin D protects human endothelial cells from oxidative stress through the autophagic and survival pathways. J Clin Endocrinol Metab 2014, 99 (4): 1367-1374.
[13] Bao BY, Ting HJ, Hsu JW, Lee YF. Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells. Int J Cancer 2008, 122 (12): 2699-2706.
[14] Bird, A.C., et al., An international classification and grading system for age-related maculopathy and age-related macular degeneration. Survey of Ophthalmology, 1995. 39 (5): p. 367.
[15] Klein, R., Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology, 1992. 99.
[16] Se Joon Woo, Jeeyun Ahn, Margaux A Morrison, et al. Analysis of Genetic and Environmental Risk Factors and Their Interactions in Korean Patients with Age-Related Macular Degeneration. 2017, 10 (7).
[17] Sasaki, M., et al., Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population. Sci Rep, 2018. 8 (1).
[18] Varma, R., et al., Prevalence of Age-Related Macular Degeneration in Chinese American Adults: The Chinese American Eye Study. Jama Ophthalmology, 2014. 134 (5).
[19] Parekh N, Chappell RJ, Millen AE, Albert DM, Mares JA. Association between vitamin D andage-related macular degeneration in the Third National Health and Nutrition Ex amination Survey, 1988 through 1994. Arch Ophthalmol 2007, 125 (5): 661-669.
[20] Golan S, Shalev V, Treister G, Chodick G, Loewenstein A. Reconsidering the connection between vitamin D levels and age-related macular degeneration. Eye 2011, 25 (9): 1122-1129.
[21] Cougnard-Gregoire A, Merle BM, Korobelnik JF, Rougier MB, Delyfer MN, Feart C, LeGoff M, Dartigues JF, Barberger-Gateau P, Delcourt C. Vitamin D Deficiency in Community-Dwelling Elderly Is Not Associated with Age-Related Macular Degeneration. J Nutr 2015, 145 (8): 1865-1872.
[22] Hashemi R, Bandarian M, Abedi-Taleb E, Khojasteh H, Khedmat L, Asadollahi E, Beytollahi M, Jelodar AM. The association between blood vitamins D and E with age-related macular degeneration: A pilot study. Interv Med Appl Sci 2018, 10 (3): 127-132.
[23] McKay GJ, Young IS, McGinty A, Bentham GC, Chakravarthy U, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F et al. Associations between Serum Vitamin D and Genetic Variants in Vitamin D Pathways and Age-Related Macular Degeneration in the European Eye Study. Ophthalmology 2017, 124 (1): 90-96.
[24] Merle BMJ, Silver RE, Rosner B, Seddon JM. Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci 2017, 58 (11): 4569-4578.
[25] Kim EC, Han K, Jee D. Inverse relationship between high blood 25-hydroxyvitamin D and late stage of age-related macular degeneration in a representative Korean population. Invest Ophthalmol Vis Sci 2014, 55 (8): 4823-4831.
[26] Millen AE, Voland R, Sondel SA, Parekh N, Horst RL, Wallace RB, Hageman GS, Chappell R, Blodi BA, Klein ML et al. Vitamin D status and early age-related macular degeneration in postmenopausal women. Arch Ophthalmol 2011, 129 (4): 481-489.
[27] Parekh, Niyati. Association Between Vitamin D and Age-Related Macular Degeneration in the Third National Health and Nutrition Examination Survey, 1988 Through 1994 [J]. Archives of Ophthalmology, 2007, 125 (5): 661.
[28] Matthew S. Seasonal, ethnic and gender variations in serum vitamin D3 levels in the local population of Peterborough [J]. Bioscience Horizons, 3, 2 (2010-5-3) (2): 124-131.
[29] Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 Mar 20; 21 (3): 319-29. doi: 10.1016/j.chembiol.2013.12.016. Epub 2014 Feb 13. PMID: 24529992; PMCID: PMC3968073.
[30] H, W. and H. ME, Regulation of signaling events involved in the pathophysiology of neovascular AMD. Molecular vision, 2016. 22: p. 189-202.
[31] F, P., et al., Mechanism of inflammation in age-related macular degeneration. Mediators of inflammation, 2012. 2012: p. 546786.
[32] T, Y., et al., The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. The Journal of clinical investigation, 2005. 115 (10): p. 2793-800.
[33] Wang, J., K. Ohno-Matsui and I. Morita, Elevated amyloid β production in senescent retinal pigment epithelium, a possible mechanism of subretinal deposition of amyloid β in age-related macular degeneration. Biochemical & Biophysical Research Communications, 2012. 423 (1).
[34] Anderson, D.H., et al., Characterization of β amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Experimental Eye Research, 2004. 78 (2): p. 243-256.
[35] V, L., et al., Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function. Neurobiology of aging, 2012. 33 (10): p. 2382-9.
[36] KM, G., et al., Age-related macular degeneration--emerging pathogenetic and therapeutic concepts. Annals of medicine, 2006. 38 (7): p. 450-71.
[37] M, C., et al., Immune activation in retinal aging: a gene expression study. Investigative ophthalmology & visual science, 2010. 51 (11): p. 5888-96.
[38] S, S., et al., 9-cis-Retinoic Acid and 1,25-dihydroxy Vitamin D3 Improve the Differentiation of Neural Stem Cells into Oligodendrocytes through the Inhibition of the Notch and Wnt Signaling Pathways. Iranian journal of medical sciences, 2018. 43 (5): p. 523-532.
[39] M, B., et al., 1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells. Molecular cancer therapeutics, 2007. 6 (4): p. 1433-9.