To explore the relationship between serum 25-hydroxyvitamin D and early AMD. Methods. This study involved a total of 3,352 subjects older than 45 years who participated in physical examination in East China sanatorium from January to September in 2019.All participants underwent fundus photographs, evaluation of blood 1-25-hydroxyvitamin D levels and comprehensive physical examination.The t-test,variance analysis and logistic regression was used to access the date in statistical way by using SPSS 25.0 statistical software. Results. The incidence of AMD in population who older than 45 years was 10.35%. The incidence of AMD Levels of serum vitamin D were negatively correlated with early AMD.The odds ratio (OR) and 95% confidence interval for early AMD among subjects in the lowest vs highest quintile of serum vitamin D was 1.48(95% CI,1.07-2.12). 25-VD, gender,age, hypertension, smoking were independent risk factors of AMD. Conclusion.This study shows that vitamin D may have a protective effect on early AMD.Further studies are needed to confirm their association.

Jing Wang, Xiaolong Yang and Tingli Chen. Association Between Circulating Vitamin D Concentration and early AMD in Shanghai Public Institution Population. International Journal of Frontiers in Medicine (2020), Vol. 2, Issue 3: 16-26. https://doi.org/10.25236/IJFM.2020.020303.

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