International Journal of New Developments in Engineering and Society, 2020, 4(3); doi: 10.25236/IJNDES.040311.
Anqi Lin 1, Shitao Sun 2, Zhen Liu 3
1. Northwood High School-4515 Portola Pkwy, Irvine, CA 92620, United States
2. Ohio State University2,Columbus,43085,America
3. Zhongnan University of Economics and Law3, Wuhan, Hubei province 430000, China
This research paper is written with the aim to investigate the efficiency of natural products, specially targeting on Taxol, Artemisinin, and Ginkgo Biloba. Those three drugs are the substances extracted from the natural products. While Taxol is mainly anti-cancer, Artemisinin is anti-malarial, and the Ginkgo Biloba is antioxidant. According to the several studies and database, the claim is that those natural product drugs are petty effective on treating specific disease. For the future expectations, there should be more clinical trials that identifying the safety, efficiency, optimal dosages and other treating diseases.
Taxol, Artemisinin, Ginkgo Biloba, natural product, efficiency
Anqi Lin, Shitao Sun, Zhen Liu. The Efficiency of The Natural Product. International Journal of New Developments in Engineering and Society (2020) Vol.4, Issue 3: 113-132. https://doi.org/10.25236/IJNDES.040311.
Alan Sandler, M.D., Robert Gray, Ph.D., Michael C. Perry, M.D., Julie Brahmer, M.D., Joan H. Schiller, M.D., Afshin Dowlati, M.D., Rogerio Lilenbaum, M.D., and David H. Johnson, M.D. “Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer. ” New England Journal of Medicine. 14.Dec 2006.
Anthony, Kiara. “Can Artemisinin Treat Cancer? Research and Side Effects.” Healthline, Healthline Media, 1 July 2013, www.healthline.com/health/artemisinin-cancer#side-effects.
Beth A. Weaver1.William Bement. “How Taxol/paclitaxel kills cancer cells.” Mol Biol Cell. 2014 Sep 15; 25(18)
Cauldwell, Dr Anna. “Mutations in Key Gene Drive Malaria Drug Resistance.” BioNews, 26 Jan. 2015, www.bionews.org.uk/pag e_94889.
Chang Y S, Jalgaonkar S P, Middleton J D, et al. “Stress-inducible gene Atf3 in the noncancer host cells contributes to chemotherapy-exacerbated breast cancer metastasis[J]. ” Proceedings of the National Academy of Sciences, 2017, 114(34):
Cui, Liwang, and Xin-zhuan Su. “Discovery, Mechanisms of Action and Combination Therapy of Artemisinin.” Expert Review of Anti-Infective Therapy, U.S. National Library of Medicine, Oct. 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2778258/.
(www.dw.com), Deutsche Welle. “Germany: Scientists Test Artemisia Plant against Coronavirus: DW: 25.06.2020.” DW.COM, 25 June 2020, www.dw.com/en/germany-scientists-test-artemisia-plant-against-coronavirus/a-53944514
 “Docetaxel and Paclitaxel in the treatment of Breast cancer: A review of clinical experience.” The oncologist.
“Fact Sheet about Malaria.” World Health Organization, World Health Organization, 14 Jan. 2020, www.who.int/news-room/fact-sheets/detail/malaria.
“Fact Sheet: World Malaria Report 2016.” World Health Organization, World Health Organization, 21 Feb. 2017, www.who.int/malaria/media/world-malaria-report-2016/en/.
Gopal, Suhasini R., et al. “Unconventional Secretory Pathway Activation Restores Hair Cell Mechanotransduction in an USH3A Model.” PNAS, National Academy of Sciences, 28 May 2019, www.pnas.org/content/116/22/11000.
“Https://Www.sciencedirect.com/Science/Article/Pii/S0301008202000151#BIB160.” The Internet Stroke Center. An Independent Web Resource for Information about Stroke Care and Research., www.strokecenter.org/patients/about-stroke/ischemic-stroke/.
Jianfang Zhang . “A Detailed Chronological Record of Project 523 and the Discovery and Development of Qinghaosu (Artemisinin).” Google Books, Google, 2013, books.google.com/books?hl=en&lr=&id=fFaxhXYg8uAC&oi=fnd&pg=PR13&dq=Zhang%2BJ.F.%2BA%2BDetailed%2BChronological%2BRecord%2Bof%2BProject%2B523%2Band%2Bthe%2BDiscovery%2Band%2BDevelopment%2Bof%2BQinghaosu%2B%28Artemisinin%29%2B2005%2BYang%2BCheng%2BEvening%2BNews%2BPublishing%2BCompany%2B&ots=-Y8WrSXvtn&sig=AiDXJ8uN8_baMP_CqP-2R-SuWjc#v=onepage&q&f=false.
Karagiannis G S, Pastoriza J M, Wang Y, et al. “Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism[J].” Science translational medicine, 2017, 9(397).
Karen Zusi. “Antimalarial Drug Mechanism Explained.” The Scientist Magazine®, 29 Dec. 2015, www.the-scientist.com/the-nutshell/antimalarial-drug-mechanism-explained-34305.
Keklikoglou I, Cianciaruso C, Güç E, et al. “Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models[J]. ” Nature Cell Biology, 2018: 1.
Krishna, Sanjeev, et al. “Artemisinins: Their Growing Importance in Medicine.” Trends in Pharmacological Sciences, Published By Elsevier In Association With The International Union Of Pharmacology, Oct. 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2758403/figure/fig1/.
“Latest Buzz: Malaria Drug May Help Prevent Genetic Hearing Loss.” GEN, 12 June 2019, www.genengnews.com/topics/omics/latest-buzz-malaria-drug-may-help-prevent-genetic-hearing-loss/.
Lieberman, Harris R., et al. “Moderate Doses of Commercial Preparations of Ginkgo Biloba Do Not Alter Markers of Liver Function but Moderate Alcohol Intake Does: A New Approach to Identify and Quantify Biomarkers of 'Adverse Effects' of Dietary Supplements.” Regulatory Toxicology and Pharmacology, Academic Press, 24 Dec. 2016,https://www.sciencedirect.com/science/article/pii/S0273230016303920
Lisa Volk-Draper, Kelly Hall, Caitlin Griggs, Sandeep Rajput, Pascaline Kohio, David DeNardo and Sophia Ran. “Paclitaxel Therapy Promotes Breast Cancer Metastasis in a TLR4-Dependent Manner.” Cancer research. Oct 2014
Maclennan, Karyn M, et al. “The CNS Effects of Ginkgo Biloba Extracts and Ginkgolide B.” Progress in Neurobiology, Pergamon, 16 July 2002, www.sciencedirect.com/science/article/pii/S0301008202000151#BIB160.
 Mahadevan, S., and Y. Park. “Multifaceted Therapeutic Benefits of Ginkgo Biloba L.: Chemistry, Efficacy, Safety, and Uses.” Wiley Online Library, John Wiley & Sons, Ltd, 12 Dec. 2007, onlinelibrary.wiley.com/doi/full/10.1111/j.1750-3841.2007.00597.x.
Mahady, Gail B. “Ginkgo Biloba for the Prevention and Treatment of... : Journal of Cardiovascular Nursing.” LWW, July 2002, https://journals.lww.com/jcnjournal/Abstract/2002/07000/Ginkgo_Biloba_for_the_Prevention_and_Treatment_o f.4.aspx
Natalie Slivinski. “Are We Headed for a New Era of Malaria Drug Resistance?” The Scientist Magazine®, 28 Feb. 2019, www.the-scientist.com/features/are-we-headed-for-a-new-era-of-malaria-drug-resistance--65496#reference1.
 Offord, Catherine. “Plant Engineered to Produce Higher Levels of Antimalarial Compound.” The Scientist Magazine®, 25 Aug. 2018, www.the-scientist.com/the-nutshell/plant-engineered-to-produce-higher-levels-of-antimalarial-compound-33347.
“Paclitaxel as First-Line Treatment for Metastatic Breast Cancer.” 1 Apr. (1997)
Pietri S, Maurelli E, Drieu K, Culcasi M. 1997a. Cardioprotective and anti‐oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J Mol Cell Cardiol 29: 733– 42.
Pietri S, Seguin JR, D'Arbigny P, Drieu K, Culcasi M. 1997b. Ginkgo biloba extract (EGb 761) pretreatment limits free radical‐induced oxidative stress in patients undergoing coronary bypass surgery. Cardiovasc Drugs Ther 11: 121– 31.
 Popa, Andreea. “Ginkgo Biloba and Memory.” Pharmacotherapy Update from Department of Pharmacy, Cleveland Clinic , Sept. 2002, www.clevelandclinicmeded.com/medicalpubs/pharmacy/sepoct02/ginkgo.htm.
 “Q&A On Artemisinin Resistance.” World Health Organization, World Health Organization, 29 May 2019, www.who.int/malaria/media/artemisinin_resistance_qa/en/.
Saeed MEM;Krishna S;Greten HJ;Kremsner PG;Efferth T; “Antischistosomal Activity of Artemisinin Derivatives in Vivo and in Patients.” Pharmacological Research, U.S. National Library of Medicine, 21 Feb. 2016, pubmed.ncbi.nlm.nih.gov/26902577/.
 Sanjeev Kumar, Haider Mahdi, Christopher Bryant, Jay P Shah, Gunjal Garg, and Adnan Munkarah. “Clinical trials and progress with paclitaxel in ovarian cancer.” Int J Women’s Health. 19 Nov.2010.
staff, Science X. “Extracts of the Plant A. Annua Are Active against SARS-CoV-2.” Medical Xpress - Medical Research Advances and Health News, Medical Xpress, 25 June 2020, medicalxpress.com/news/2020-06-annua-sars-cov-.html.
T;, Efferth. “From Ancient Herb to Modern Drug: Artemisia Annua and Artemisinin for Cancer Therapy.” Seminars in Cancer Biology, U.S. National Library of Medicine, 28 Feb. 2017, pubmed.ncbi.nlm.nih.gov/28254675/.
“The story of Taxol.” http://www.pharmacognosy.us/wp-content/uploads/The-Story- of- Taxol.pdfa. 2 Jul. 2020
Tilley L;Straimer J;Gnädig NF;Ralph SA;Fidock DA; “Artemisinin Action and Resistance in Plasmodium Falciparum.” Trends in Parasitology, U.S. National Library of Medicine, 9 June 2016, pubmed.ncbi.nlm.nih.gov/27289273/.
Tracy Vence. “Understanding Antimalarial Drug Resistance.” The Scientist Magazine®, 20 Jan. 2015, www.the-scientist.com/the-nutshell/understanding-antimalarial-drug-resistance-36062.
Wang, Wenzhi, et al. “Prevalence, Incidence, and Mortality of Stroke in China.” Circulation, 4 Jan. 2017, www.ahajournals.org/doi/full/10.1161/circulationaha.116.025250.
Wong, Cathy. “How Ginkgo Biloba Is a Natural Way to Treat Many Conditions.” Verywell Mind, 3 Feb. 2020, www.verywellmind.com/ginkgo-what-should-you-know-about-it-88329.
Wong YK;Xu C;Kalesh KA;He Y;Lin Q;Wong WSF;Shen HM;Wang J; “Artemisinin as an Anticancer Drug: Recent Advances in Target Profiling and Mechanisms of Action.” Medicinal Research Reviews, U.S. National Library of Medicine, 23 June 2017, pubmed.ncbi.nlm.nih.gov/28643446/.