Shanghai Pinghe School, shanghai 201206 china
Oxamniquine is a drug which developed to treat with schistosomiasis, an pandemic disease caused by flatworm which resulted in nearly 500,000 death every year. The design of oxamniquine begin with the lead compound lucanthone. Through modifications on pharmacophores, the less toxic, orally active and more effective drug oxamniquine is obtained. The synthesis of oxamniquine begin with a molecule with quinoline structure. Currently, the synthesis of oxamniquine needs to undergo different kinds of reactions, including substitution and reduction.
Schistosomiasis; oxamniquine; drug design; synthesis; side effects
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