Welcome to Francis Academic Press

Academic Journal of Medicine & Health Sciences, 2020, 1(1); doi: 10.25236/AJMHS.2020.010113.

The Design of Oxamniquine


Pinyi Li

Corresponding Author:
Pinyi Li

Shanghai Pinghe School,  shanghai   201206  china


Oxamniquine is a drug which developed to treat with schistosomiasis, an pandemic disease caused by flatworm which resulted in nearly 500,000 death every year.[1] The design of oxamniquine begin with the lead compound lucanthone. Through modifications on pharmacophores, the less toxic, orally active and more effective drug oxamniquine is obtained. The synthesis of oxamniquine begin with a molecule with quinoline structure. Currently, the synthesis of oxamniquine needs to undergo different kinds of reactions, including substitution and reduction.


Schistosomiasis; oxamniquine; drug design; synthesis; side effects

Cite This Paper

Pinyi Li. The Design of Oxamniquine. Academic Journal of Medicine & Health Sciences (2020) Vol. 1, Issue 1: 80-86. https://doi.org/10.25236/AJMHS.2020.010113.


[1] Graham L. Patrick (2013). An introduction to Medicinal Chemistry (fifth edition). Retrieved September, 2020, from: https://www.academia.edu/36903466/An_Introduction_to_Medicinal_Chemistry_Fifth_Edition_Graham_L_Patrick
[2] J.K. Aronson (2016). Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (Sixteenth Edition). Retrieved September, 2020, from ScienceDirect: https://www.sciencedirect.com/topics/neuroscience/oxamniquine