The Frontiers of Society, Science and Technology, 2020, 2(15); doi: 10.25236/FSST.2020.021517.
Wanxin Li1, Jiaxin Bao2, Yeye Ji3
1. International department of Wuhan No.6 high school, Wuhan, Hubei, 430016;
2. Shanghai Jiaotong University A-Level International Curriculum Centre, Shanghai, 201101;
3. Nanjing Medical University, Jiangsu, Nanjing, 211166
Microbiome plays a crucial role in balancing our body. Obesity is a prevailing disease among the whole world without any sufficient drugs to deal with the increasing risks of later syndromes, which is why our group wants to pay more attention on it. Obesity is a severe disease which has been ignored by the public, while microbiome is known to benefit our body. We should give priority to know how these two are actually the case, what the mechanisms of them are and what the contribution of them is. On the basis of previous researches on treating obesity with microbiome such as after weight-loss intervention, our group also came up with new ideas of treatment which aimed at digestion and plantation in the area of pharmacology, immunology and psychology. However, certain studies must be carried out to test whether these innovations are workable.
Microbiome; Obesity; Mechanism; Treatment
Wanxin Li, Jiaxin Bao, Yeye Ji. Gut microbiome and Obesity: A new attempt on obesity treatment. The Frontiers of Society, Science and Technology (2020) Vol. 2 Issue 15:144-151. https://doi.org/10.25236/FSST.2020.021517.
[1] Collaboration NCDRF, Lancet 2016, 387, 1377.《Engineering the gut microbiome for treatment of obesity: a review of current understanding and progress》
[2] https://www.cdc.gov/obesity/data/adult.html. 《Engineering the gut microbiome for treatment of obesity: a review of current understanding and progress》
[3] S. U. Dombrowski, K. Knittle, A. Avenell, V. Araujo-Soares, F. F. Sniehotta, BMJ 2014, 348, g2646. 《Engineering the gut microbiome for treatment of obesity: a review of current understanding and progress》
[4] M. W. Schwartz, R. J. Seeley, L. M. Zieltser, A. Drewnowski, E. Ravussin, L. M. Redman, R. L. Leibel, Endocr. Rev. 2017, 38, 267.《Engineering the gut microbiome for treatment of obesity: a review of current understanding and progress》
[5] S. U. Dombrowski, K. Knittle, A. Avenell, V. Araujo-Soares, F. F. Sniehotta, BMJ 2014, 348, g2646.《Engineering the gut microbiome for treatment of obesity: a review of current understanding and progress》
[6] G. Fruhbeck, Nat. Rev. Endocrinol. 2015, 11, 465.《Engineering the gut microbiome for treatment of obesity: a review of current understanding and progress》
[7] A. Papalazarou, M. Yannakoulia, S. A. Kavouras, V. Komesidou, G. Dimitriadis, A. Papakonstantinou, L. S. Sidossis, Obesity (Silver Spring) 2010, 18, 1348.《Engineering the gut microbiome for treatment of obesity: a review of current understanding and progress》
[8] R. Christensen, P. K. Kristensen, E. M. Bartels, H. Bliddal, A. Astrup, Lancet 2007, 370, 1706.《Engineering the gut microbiome for treatment of obesity: a review of current understanding and progress》
[9] W. P. James, I. D. Caterson, W. Coutinho, N. Finer, L. F. Van Gaal, A. P. Maggioni, C. Torp-Pedersen, A. M. Sharma, G. M. Shepherd, R. A. Rode, C. L. Renz, S. Investigators, N. Engl. J. Med. 2010, 363, 905.《Engineering the gut microbiome for treatment of obesity: a review of current understanding and progress》
[10]Premysl Bercik,Emmanuel Denou,Josh Collins,Wendy Jackson,Jun Lu,Jennifer Jury,Yikang Deng,Patricia Blennerhassett,Joseph Macri,Kathy D. McCoy,Elena F. Verdu,Stephen M. Collins. The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice[J]. Gastroenterology,2011,141(2).
[11]Lim YY, Lee YS, Ooi DSQ. Engineering the Gut Microbiome for Treatment of Obesity: A Review of Current Understanding and Progress [published online ahead of print, 2020 Jul 14]. Biotechnol J. 2020;e2000013. doi:10.1002/biot.202000013
[12]Everard A, Belzer C, Geurts L, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 2013;110(22):9066-9071. doi:10.1073/pnas.1219451110
[13]Liu R, Hong J, Xu X, et al. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017;23(7):859-868. doi:10.1038/nm.4358
[14]Rieder R, Wisniewski PJ, Alderman BL, Campbell SC. Microbes and mental health: A review. Brain Behav Immun. 2017;66:9-17. doi:10.1016/j.bbi.2017.01.016