With the advancement of imaging detection methods, the detection rate of intracranial aneurysms is increasing year by year. At the same time, the compressive cerebral neuropathy caused by the aneurysm itself and the brain injury caused by ruptured hemorrhage seriously affect the quality of life of patients.Because of the special blood flow pattern in aneurysms, hemodynamics has been a research hotspot in the field of aneurysms. At present, there is still no consensus on the study of hemodynamics in the occurrence, development and rupture mechanism of intracranial aneurysms.In this paper, the research progress of hemodynamic parameters such as shear force, blood flow pattern, computational fluid dynamics in intracranial aneurysms is summarized in combination with relevant literatures in recent years.

Chengfu Ji, Qing Yu, Jun Wang, Zixuan Liu, Dongyuan Hu, Chonghua Yuan. Application and Progress of Computational Fluid Dynamics in the Study and Treatment of Intracranial Aneurysms. International Journal of Frontiers in Sociology (2020), Vol. 2, Issue 8: 74-80. https://doi.org/10.25236/IJFS.2020.020810.

[1] Ravindra VM, de Havenon A, Gooldy TC, et al. Validation of the unruptured intracranial aneurysm treatment score: comparison with real-world cerebrovascular practice[J]. J Neurosurg, 2018, 129: 100-106
[2] Feng X, Qian Z, Zhang B, et al. Number of Cigarettes Smoked Per Day, Smoking Index, and Intracranial Aneurysm Rupture: A Case-Control Study[J]. Front Neurol, 2018, 9: 380
[3] Kaminogo M, Yonekura M, Shibata S. Incidence and outcome of multiple intracranial aneurysms in a defined population [J]. Stroke, 2003, 34: 16-21
[4] Seibert B, Tummala RP, Chow R, et al. Intracranial aneurysms: review of current treatment options and outcomes[J]. Front Neurol, 2011, 2: 45
[5] Wiebers DO, Whisnant JP, Huston JR, et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment[J], Lancet, 2003, 362: 103-110
[6] Nieuwkamp DJ, Setz LE, Algra A, et al. Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis[J]. Lancet Neurol, 2009, 8: 635-642
[7] Nixon AM, Gunel M, Sumpio BE. The critical role of hemodynamics in the development of cerebral vascular disease[J]. J Neurosurg, 2010, 112: 1240-1253
[8] Xiang J, Natarajan SK, Tremmel M, et al. Hemodynamicmorphologic discriminants for intracranial aneurysm rupture[J]. Stroke, 2011, 42: 144-152
[9] Walcott BP, Reinshagen C, Stapleton CJ, et al. Predictive modeling and in vivo assessment of cerebral blood flow in the management of complex cerebral aneurysms[J]. J Cereb Blood Flow Metab, 2016, 36: 998-1003
[10] Karmonik C, Diaz O, Klucznik R, et al. Quantitative comparison of hemodynamic parameters from steady and transient CFD simulations in cerebral aneurysms with focus on the aneurysm ostium[J]. J Neurointerv Surg, 2015, 7: 367-372
[11] Fr sen J. Flow Dynamics of Aneurysm Growth and Rupture: Challenges for the Development of Computational Flow Dynamics as a Diagnostic Tool to Detect Rupture-Prone Aneurysms[J]. Acta Neurochir Suppl, 2016, 123: 89-95
[12] Wong GK, Poon WS. Current status of computational fluid dynamics for cerebral aneurysms: the clinician's perspective[J]. J Clin Neurosci, 2011, 18: 1285-1288
[13] Baek H, Jayaraman MV, Richardson PD, et al. Flow instability and wall shear stress variation in intracranial aneurysms[J]. J RSoc Interface, 2010, 7: 967-988
[14] Miura Y, Ishida F, Umeda Y, et al. Low wall shear stress is independently associated with the rupture status of middle cerebral artery aneurysms[J]. Stroke, 2013, 44: 519-521
[15] Cebral JR, Mut F, Weir J, et al. Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms[J]. AJNR Am J Neuroradiol, 2011, 32: 145-151
[16] Kadasi LM, Dent WC, Malek AM. Cerebral aneurysm wall thickness analysis using intraoperative microscopy: effect of size and gender on thin translucent regions[J]. J Neurointerv Surg, 2013, 5: 201-206
[17] Kataoka K, Taneda M, Asai T, et al. Structural fragility and inflammatory response of ruptured cerebral aneurysms. A comparative study between ruptured and unruptured cerebral aneurysms[J]. Stroke, 1999, 30: 1396-1401
[18] Kataoka K, Taneda M, Asai T, et al. Difference in nature of ruptured and unruptured cerebral aneurysms[J]. Lancet, 2000, 355: 203
[19] Metaxa E, Tremmel M, Natarajan SK, et al. Characterization of critical hemodynamics contributing to aneurysmal remodeling at the basilar terminus in a rabbit model[J]. Stroke, 2010, 41: 1774-1782
[20] Kolega J, Gao L, Mandelbaum M, et al. Cellular and molecular responses of the basilar terminus to hemodynamics during intracranial aneurysm initiation in a rabbit model[J]. J Vasc Res, 2011, 48: 429-442
[21] Meng H, Tutino VM, Xiang J, et al. High WSS or Low WSS Complex interactions of hemodynamics with intracranial aneurysm initiation， growth， and rupture: toward a unifying hypothesis[J]. AJNR Am J Neuroradiol, 2014, 35: 1254-1262
[22] Galis ZS, Sukhova GK, Lark MW, et al. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques[J]. J Clin Invest, 1994, 94: 2493-2503
[23] Chiu JJ, Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives[J]. Physiol Rev, 2011, 91: 327-387
[24] Ross R. Atherosclerosis-an inflammatory disease[J]. N Engl J Med, 1999, 340: 115-126
[25] Mandelbaum M, Kolega J, Dolan JM, et al. A critical role for proinflammatory behavior of smooth muscle cells in hemodynamic initiation of intracranial aneurysm [J]. PLoS One, 2013, 8:e74357.
[26] Sforza DM, Kono K, Tateshima S, et al. Hemodynamics in growing and stable cerebral aneurysms[J]. J Neurointerv Surg, 2016, 8: 407-412
[27] Zhang Y, Hao J, Zheng Y, et al. Role of Kruppel-like factors in cancer stem cell[J]. J Physiol Biochem, 2015, 71: 155-164