Frontiers in Sport Research, 2021, 3(2); doi: 10.25236/FSR.2021.030209.
Zekai Wu
School of Sports Science, Tianjin Normal University, Tianjin 300387, China
The purpose of this article is to study the effect of exercise training on neuronal morphology of somatosensory regions and caudate putamen in the cerebral cortex of mice. In this paper, 20 female mice of Kunming species and 20 mice were paired and randomly assigned to the exercise group and the control group. The exercise group mice performed physical activities. After 8 weeks of exercise training on the exercise treadmill, in a quiet state, tissue sections of the somatosensory area of the cerebral cortex were prepared and HE stained. The changes in tissue morphology were observed under an optical microscope and cell counts were performed. The mice were sacrificed during sexual maturity and senescence, and seven morphological parameters in the frontal cortex neurons of two types of mice were measured by cytomorphometry. The test was used to compare the differences between the parameters of different groups. To a certain extent, it can promote the increase of 12% in the nucleolus of canine pyramidal cells in the sensory area of the cerebral cortex of the white mice, and the increase in the density of the spinal cyst spines in the middle pyramidal cells of the sixth layer and the middle astrocytes of the caudal shell. The conclusion shows that proper exercise can increase the activity of neurons in the caudate putamen of the rat brain, which is beneficial to the transmission of neurons and the release of transmitters, and promotes the function of the brain.
exercise training, somatosensory of cerebral cortex, neurons of caudate putamen, mouse experiment
Zekai Wu. The Mechanism of the Effect of Exercise Training on the Morphology of Neurons in the Caudate Putamen of the Mice. Frontiers in Sport Research (2021) Vol. 3, Issue 2: 36-42. https://doi.org/10.25236/FSR.2021.030209.
[1] Adeluyi, A., Guerin, L., Fisher, M. L., Galloway, A., Cole, R. D., Chan, S. S., ... & Turner, J. R. (2019) “Microglia Morphology and ProinflammatorySignaling in the Nucleus Accumbens during Nicotine Withdrawal”, Science advances, 5(10), pp. eaax7031.
[2] Bechard, A. R., Cacodcar, N., King, M. A., & Lewis, M. H. (2016) “How does Environmental Enrichment Reduce Repetitive Motor Behaviors? Neuronal Activation and Dendritic Morphology in the Indirect Basal Ganglia Pathway of a Mouse Model”, Behavioural brain research, 299, pp. 122-131.
[3] Wang, Z., Stefanko, D. P., Guo, Y., Toy, W. A., Petzinger, G. M., Jakowec, M. W., &Holschneider, D. P. (2016) “Evidence of Functional Brain Reorganization on the Basis of Blood flow Changes in the CAG140 Knock-in Mouse Model of Huntington’s Disease”, NeuroReport, 27(9), pp. 632-639.
[4] Holschneider, D. P., Guo, Y., Wang, Z., Vidal, M., &Scremin, O. U. (2019) “Positive Allosteric Modulation of Cholinergic Receptors Improves Spatial Learning after Cortical Contusion Injury in Mice”, Journal of neurotrauma, 36(14), pp. 2233-2245.
[5] Rüb, U., Seidel, K., Heinsen, H., Vonsattel, J. P., den Dunnen, W. F., &Korf, H. W. (2016) “H untington's disease (HD): The Neuropathology of a Multisystem Neurodegenerative Disorder of the Human Brain”, Brain Pathology, 26(6), pp. 726-740.
[6] Olateju, O. I., Spocter, M. A., Patzke, N., Ihunwo, A. O., & Manger, P. R. (2018) “Hippocampal Heurogenesis in the C57BL/6J Mice at Early Adulthood following Prenatal Alcohol Exposure”, Metabolic brain disease, 33(2), pp. 397-410.
[7] Labus, J. S., Hollister, E. B., Jacobs, J., Kirbach, K., Oezguen, N., Gupta, A., ... &Savidge, T. (2017) “Differences in Gut Microbial Composition Correlate with Regional Brain Volumes in irritable bowel syndrome”, Microbiome, 5(1), pp. 49.
[8] Martinez‐de‐la‐Torre, M., Lambertos, A., Peñafiel, R., &Puelles, L. (2018) “An Exercise in brain Genoarchitectonics: Analysis of AZIN2‐Lacz Expressing Neuronal Populations in the Mouse Hindbrain”, Journal of neuroscience research, 96(9), pp. 1490-1517.
[9] Zhang, C., Ni, P., Liu, Y., Tian, Y., Wei, J., Xiang, B., ...&Guo, W. (2020) “GABAergicAbnormalities Associated with Sensorimotor Cortico-striatal Community Structural Deficits in ErbB4 Knockout Mice and First-episode Treatment-naïve Patients with Schizophrenia”, Neuroscience Bulletin, 36(2), pp. 97-109.
[10] Wilhelm, I., Nyúl-Tóth, Á.,Suciu, M., Hermenean, A., &Krizbai, I. A. (2016) “Heterogeneity of the Blood-brain Barrier”, Tissue barriers, 4(1), pp. e1143544.
[11] Ferrazzoli, D., Ortelli, P., Madeo, G., Giladi, N., Petzinger, G. M., & Frazzitta, G. (2018) “Basal Ganglia and Beyond: the Interplay between Motor and Cognitive Aspects in Parkinson’s DiseaseRehabilitation”, Neuroscience &Biobehavioral Reviews, 90, pp. 294-308.
[12] Avivi-Arber, L., Seltzer, Z. E., Friedel, M., Lerch, J. P.,Moayedi, M., Davis, K. D., & Sessle, B. J. (2017) “Widespread Volumetric Brain Vhanges following Tooth Loss in Female Mice”, Frontiers in neuroanatomy, 10, pp. 121.