The incidence of hypertension is high in China, and the mortality and disability rate of its complications are high. Metabonomics can accurately reflect the real-time metabolism of organisms. The syndrome type of traditional Chinese medicine is a pathological summary of the development stage of the disease. The integrity, systematicness and dynamics of metabonomics are highly consistent with the holistic view and syndrome differentiation view of TCM theory. In recent years, the use of metabonomics technology in the research of TCM syndrome has achieved certain results, and the angle and depth of the research are constantly expanding. Therefore, the purpose of this paper is to explore the effect of traditional Chinese medicine on the metabolites of hypertension by metabonomics. With a view to more accurate clinical application of traditional Chinese medicine.

Huan Hao, Junru Zhang. Progress in the Application of metabonomics in the intervention of traditional Chinese Medicine on Hypertension. International Journal of Frontiers in Medicine (2021), Vol. 3, Issue 2: 15-22. https://doi.org/10.25236/IJFM.2021.030204.

[1] 2018 Chinese guidelines for the management of Hypertension [J].Chinese Journal of Cardiovascular, 2019, 24(01): 24-56. (Chinese)

[2] Erlic Zoran et al. Targeted Metabolomics as a Tool in Discriminating Endocrine From Primary Hypertension [J]. The Journal of Clinical Endocrinology & Metabolism, 2021, 106(4): 1111-1128.

[3] Deng Yueting et al. Identification of biomarkers for essential hypertension based on metabolomics. [J]. Nutrition, metabolism, and cardiovascular diseases: NMCD, 2021, 31(2): 382-395.

[4] Wang Xiaoxiao, Wang Haixia, Zuo Deyun, Huang Guoqing. Progress in the Application of metabonomics and its Analytical techniques in Medical Research [J]. Chinese Modern Doctor, 2019, 57(01): 165-169. (Chinese)

[5] Wang Lulu, Li Bing, Wang Fengyi, Zhang Jing. Application of systematic biology technology in research of traditional Chinese Medicine based on overall research [J]. Chinese Traditional and Herbal Drugs, 2020, 51(19): 5053-5064. (Chinese)

[6] Wang Siting, Li Xiaona, Wang Meng, Ling Xiaomei. Metabonomics and its analytical techniques [J]. Chinese Journal of Pharmaceutical Analysis, 2010, 30(09): 1792-1799. (Chinese)

[7] Li Ning, Fan Xuemei, Wang Yiming, Wang Yu, Luo Guoan. Development of metabonomics and its analytical technique [J].Central South Pharmacy, 2014, 12(07): 668-673. (Chinese)

[8] Wu Wenze, Ling Huting, Gao Yao, Zhao Yunhao, Han Yumei, Qin Xuemei, Tian Junsheng. Progress in the Application of stable isotope-resolved metabolomics in glucose catabolism [J/OL]. Acta Pharmaceutica Sinica: 1-16 [2021-05-06].

[9] Liu Jiamei, Liu Jia, Cai Jun, Chen Mulei, Yang Xinchun.Metabolomics of essential hypertension [J]. Chinese Journal of Hypertension, 2016, 24(04): 340-347. (Chinese)

[10] Wang Xiaoxiao, Wang Haixia, Zuo Deyun. Current status of metabonomics research on essential hypertension, 2019, 40(05): 1109-1112. (Chinese)

[11] Lu Jiayu, Shi Wenxiang, Kong Xiangqing. Research progress in metabolomics of hypertension [J]. Journal of Nanjing Medical University (Natural Science), 2021, 41(02): 286-291. (Chinese)

[12] Yumin Liu et al. An ultrasonication-assisted extraction and derivatization protocol for GC/TOFMS-based metabolite profiling [J]. Analytical and Bioanalytical Chemistry, 2011, 400(5): 1405-1417.

[13] Deng Yueting et al. Identification of biomarkers for essential hypertension based on metabolomics. [J]. Nutrition, metabolism, and cardiovascular diseases: NMCD, 2021, 31(2): 382-395.

[14] Nikolic Sonja B et al. Metabolomics in hypertension. [J]. Journal of hypertension, 2014, 32(6): 1159-69.

[15] Xiangyang Liu et al. Serum metabolomic response to exercise training in spontaneously hypertensive rats [J]. Journal of the American Society of Hypertension, 2017, 11(7): 428-436.

[16] Cao Huizhe, Ha Xiaoqin, Li Xueyan, Xu Qian, Bai Yanqing, Zeng Tongxu. Molecular mechanism of free fatty acids-induced insulin resistance [J]. Medical Journal of Chinese People’s Liberation Army, 2017, 42(01): 81-85. (Chinese)

[17] Mahbub M H et al. Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension. [J]. Nutrients, 2020, 12 (12)

[18] Cynthia A. van Deventer et al. Use of metabolomics to elucidate the metabolic perturbation associated with hypertension in a black South African male cohort: the SABPA study [J]. Journal of the American Society of Hypertension, 2015, 9(2): 104-114.

[19] Elaine Holmes et al. Human metabolic phenotype diversity and its association with diet and blood pressure [J]. Nature: International weekly journal of science, 2008, 453(7193): 396-400.

[20] Liu Jilun, An Ning, Ma Cong, et al. Correlation analysis of intestinal flora with hypertension.. 2018, 16(3): 2325-2330.

[21] Cani Patrice D. Human gut microbiome: hopes, threats and promises. 2018,

[22] Wang Yan, Cai Jun.Gut microbiota and cardiovascular disease [J]. Basic & Clinic Medicine, 2017, 37(05): 729-733. (Chinese)

[23] Wang Anlu, Li Qiuyi, Xu Hao, Chen Keji. Relationship between intestinal flora and atherosclerosis [J]. Chinese Journal of Arteriosclerosis, 2020, 28(02): 93-98. (Chinese)

[24] Ufnal Marcin, Jazwiec Radoslaw, Dadlez Michal, et al. Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats.. 2014, 30(12): 1700-5.

[25] Blair Mell et al. Evidence for a link between gut microbiota and hypertension in the Dahl rat [J]. Physiological Genomics, 2015, 47(6): 187-197.

[26] Yan Xuefang et al. Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension. [J]. Circulation research, 2020, 126(7): 839-853.

[27] Chen Lingshan, Chen Jinshui. Study on the essence of Hypertension Syndrome based on metabonomics [J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease, 2016, 14(02): 140-142. (Chinese)

[28] Ning Cheng, Wang Guangji, A Jiye, Hao Haiping, Chen Xiaohu, Fan Qunli. A preliminary study on metabonomics of hyperactivity of liver fire in patients with essential hypertension [J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease, 2015, 13(06): 717-720. (Chinese)

[29] Jiang Haiqiang, Li Yunlun.Metabolic Network Construction and Feature Analysis of Hypertension with Syndrome of Ascendant Hyperactivity of Liver Yang [J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2013, 15(05): 942-946. (Chinese)

[30] Wu Tianmin, Chen Jinshui, Xue Wenjuan, Gao Xiaoli.NMR Metabonomics Study on Serum Samples of Young and Middle-Age Hypertension Patients with Phlegm Dampness Retention Syndrome [J]. Chinese Journal of Information on Traditional Chinese Medicine, 2016, 23(10): 21-25. (Chinese)

[31] Fan Qunli, Wang Guangji, A Jiye, Hao Haiping, Zhu Jia, Ning Cheng, Chen Xiaohu. Study on metabonomic connotation of Yin deficiency and Yang hyperactivity Syndrome in Hypertension [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2010, 26(06): 409-411+481-482. (Chinese)

[32] Shao Ze. Study on metabonomic of Essential Hypertension Yin Deficiency and Yang Excess Syndrome Based on UHPLC-Q-TOF-MS [D]. Journal of Nanjing University of Traditional Chinese Medicine, 2020. (Chinese)

[33] Yu Ruixue, Yang Wenqing, Liu Ana, Wang Huanjun, Jiang Haiqiang, Li Yunlun. Relations between Macroscopic Characterization and Metabolomics of Rat with Hypertension of Ascendant Hyperactivity of Liver Yang Syndrome Intervened with Gouteng [J]. Journal of Traditional Chinese Medicine, 2018, 59(05): 427-434. (Chinese)

[34] Zou Linyi, Jiang Haiqiang, Zhou Honglei, Li Yunlun.Study of Rhizoma alismatis on urine metabolism in spontaneously hypertensive rats[J].China Journal of Traditional Chinese Medicine and Pharmacy, 2018, 33(09): 4151-4154. (Chinese)

[35] Feng Health, Liu Tong, Zhou Ning, Bai Zhiyao, Zhang Yanli, Yang Yanyun, Fu Yang, Zhang Yawen, Zheng Xiaoke. Metabonomics study of effects of Gardenia jasminoides Var.radicans Fruit on blood pressure in spontaneously hypertensive rats [J]. Chinese Journal of New Drugs, 2019, 28(06): 670-676. (Chinese)

[36] Han Cong, Zhou Le, Jiang Yuehua, Li Wei, Liu Yao. Study on the antihypertensive mechanism of Astragali Radix and Salvia Miltiorrhizae Radix et Rhizoma based on metabolomics [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2020, 35(09): 4352-4356. (Chinese)

[37] Luo Yingzi, Jiang Yuehua, Yang Chuanhua. Fecal Metabonomics Study of Duzhong (Eucommia ulmoides Oliv.)-Ezhu (Tribulus terrestris L.) on Reducing Blood Pressure in Elderly Spontaneously Hypertensive Rats Based on Non-Targeted Gas Chromatography-Mass Spectrometry [J]. Chinese Archives of Traditional Chinese Medicine, 2020, 38(12): 131-134+288-289. (Chinese)

[38] Wang Yulong, Lu Guangyao, Wang Yani, Zhang Huan, Zhang Shufang. Analysis of Danqi Tablets on Urine Metabolomics of Spontaneously Hypertension Rats Based on1H-NMR [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2017, 23(04): 102-107. (Chinese)

[39] Jian Weixiong, Xiao Suixi, Liu Pei, Luo Ying, Chen Yuanying, Tan Yuansheng. Metabonomic study of compound gouteng antihypertensive tablet＇s effects on left ventricular hypertrophy in hypertensive rats [J]. Journal of Beijing University of Traditional Chinese Medicine, 2018, 41(08): 655-662. (Chinese)

[40] Wu Guixia, Jiang Rui, Li Jing, Li Junhong, Lei Dongyu, Jiang Ping. 1H NMR-based metabonomic study on Urine from DanHong injection treatedspontaneously hypertensive rats [J]. Journal of Xinjiang Medical University, 2021, 44(01): 92-96. (Chinese)

[41] Gu Ping, Zhang Mingxue. Zhengan Xifeng Decoction Treating Plasma Metabonomics of YinDeficiency and Yang Hyperactivity Type of Hypertension [J]. Liaoning Journal of Traditional Chinese Medicine, 2016, 43(07): 1353-1355. (Chinese)

[42] Deng Bo, Jiang Xiaoli, Liu Bin, Zhang Shuangwei, Chen Liguo, Zhang Jingzhi. Effects of the serum of hypertensive patients with blood stasis syndrome onfunction and AMPK activation of endothelial cells [J]. Journal of Jinan University (Natural Science & Medicine Edition), 2018, 39(03): 269-276. (Chinese)

[43] Jian Weixiong, Xiao Suixi, Liu Pei, Luo Ying, Chen Yuying, Feng Yu, Wang Jianzhang, Tan Yuansheng. Metabonomics Study of Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats [J]. Journal of Hunan University of Chinese Medicine, 2018, 38(04): 365-371. (Chinese)

[44] Mingzhi Zhang et al. Association of hypertension with coexistence of abnormal metabolism and inflammation and endothelial dysfunction [J]. Blood Pressure, 2013, 22(3): 151-157.

[45] Gao Feng, Cai Qin, Cai Lun, Lu Furong. Research Update on 4-hydroxyisoleucine [J]. Herald of Medicine, 2014, 33(10): 1261-1264. (Chinese)

[46]Jane Delaney et al. Phenylacetylglycine, a putative biomarker of phospholipidosis: Its origins and relevance to phospholipid accumulation using amiodarone treated rats as a model [J]. Biomarkers, 2004, 9(3): 271-290.

[47] Zhao Lifang, Li Fang, Liu Jing, Lu Zulin. Taurine and its effect on the protection of the central nervous system [J]. Chinese Journal of Applied Clinical Pediatrics, 2015, 30(08): 635-637. (Chinese)

[48] Anthony Zulli et al. High Dietary Taurine Reduces Apoptosis and Atherosclerosis in the Left Main Coronary Artery: Association with Reduced CCAAT/Enhancer Binding Protein Homologous Protein and Total Plasma Homocysteine but not Lipidemia [J]. Hypertension, 2009, 53(6): 1017-1022.