Academic Journal of Computing & Information Science, 2021, 4(4); doi: 10.25236/AJCIS.2021.040413.
Xiangshuai Li, Xiangfen Li, Zishi Wang, Hongliang Xu
Engineering Research Center of Pesticide of Heilongjiang Province, College of Advanced Agriculture and Ecological Environment, Heilongjiang University, Harbin 150080, China
Studies have shown that high toxicity at all stages of drug development is a major limiting factor in getting a new drug to market. At present, a number of toxicity assay methods have been published in the literature. Most of them rely mainly on the UV spectrometer and manual injection. However, the manual injection has low accuracy of detection results, long detection time, complicated operation, cross-contamination, and inadequate safety factor. Therefore, it is necessary to develop an automatic sampler that is used in combination with a platform for predicting drug toxicity based on carrier protein binding information and an ultraviolet spectrophotometer. The automatic sampler for UV spectroscopy toxicity detection uses the quartz cell gripper to clamp the quartz cell and realizes the precise automatic sample injection function through the position sensor. Through the movement simulation, the whole moving process is smooth and without interference, and the movement position of the quartz cell is accurate. The research and development of the automatic sampler for UV spectroscopy toxicity detection will significantly promote the precise detection of toxicity in the early stage of drug development. The development of UV spectral toxicity detection autosampler will provide hardware support for the precise detection of toxicity in the early stage of drug development. At the same time, it will significantly shorten the drug R&D process and save a lot of R&D expenses for drug R&D.
Ultraviolet Spectroscopy. Quartz cell gripper. Toxicity detector. Position Sensor
Xiangshuai Li, Xiangfen Li, Zishi Wang, Hongliang Xu. The Automatic Sampler for UV Spectroscopy Toxicity Detection: Based on the Perspective of Binding Information with the Carrier Protein. Academic Journal of Computing & Information Science (2021), Vol. 4, Issue 4: 69-76. https://doi.org/10.25236/AJCIS.2021.040413.
 Zhou, F., Li, C., Zhu, H. and Li, Y. (2018) Simultaneous determination of trace metal ions in industrial wastewater based on uv–vis spectrometry. Optik - International Journal for Light and Electron Optics, doi: 10.1016/j.ijleo.2018.09.075.
 Passos, M. and Saraiva, M. (2019) Detection in uv-visible spectrophotometry: detectors, detection systems, and detection strategies. Measurement, 135, 896-904.
 Xing, Y., Wang, Z., Li. X., Hou, C., Chai, J., Li, X., Su, J., Gao, J. and Xu, H. (2021) A new method for predicting the acute toxicity of carbamate pesticides based on the perspective of binding information with carrier protein. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, doi: 10.1016/j.saa.2021.120188.
 Wang, X., Xing, Y,. Su, J., Wang, C., Wang, Z., Yu, Y., Xu, H. and Ma, D. (2020) Synthesis of two new naphthalene-containing compounds and their bindings to human serum albumin. Journal of Biomolecular Structure and Dynamics, doi: 10.1080/07391102.2020.1764867.
 Xie, Y. and Hou, X. (2021) Molecular Assessment of the Toxic Mechanism of the Latest Neonicotinoid Dinotefuran with Glutathione Peroxidase 6 from Arabidopsis thaliana. Journal of Agricultural and Food Chemistry, 69 (2), 638-645.