Baofeng Chen, Huan Zhang, Yun Liu
School of Basic Medical Sciences, North Sichuan Medical College, Nanchong 637000, China
Purpose: With the continuous progress and development of social economy, the process of urbanization has been significantly improved. As people’s physical fatigue and work intensity are significantly weaker than before, the way of sitting and working is significantly reduced, life and dietary habits have also undergone significant changes, high-calorie diets have further increased, and many regions and countries in the world are currently aging. At the stage of transformation, the average prevalence of diabetes is also on the rise in most parts of the world. Diabetes has become an important global public health and hygiene event in the 21st century. This article aims to study whether controlling hyperglycemia will reduce the white blood cell count and the expression of inflammatory genes. Methods: 85 diabetic patients with poor blood glucose control in a hospital were selected for three months of hypoglycemic treatment, and the difference between the groups was compared by t test. Results: After three months of hypoglycemic treatment, the improvement group showed statistically significant differences in the measured quantity counts of leukocytes, neutrophils, monocytes, and lymphocytes and in the measured quantity counts of S100A8 gene and S100A9 gene mRNAs, none of the differences in the non improvement group. Conclusion: Controlling the blood sugar of diabetic patients can reduce their white blood cell count and also have an effect on the decrease of the expression of inflammatory genes in their granulocytes and monocytes.
hyperglycemia, diabetes, white blood cells, inflammatory genes
Baofeng Chen, Huan Zhang, Yun Liu. The Correlation Study of Hyperglycemia on the Expression of White Blood cells and Inflammatory Genes in Patients with Type 2 Diabetes. International Journal of Frontiers in Medicine (2021), Vol. 3, Issue 3: 5-10. https://doi.org/10.25236/IJFM.2021.030302.
 Nunes M, Henrique M P, Guerra D, et al. Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil[J]. BMC Public Health, 2018, 18(1):989-.
 Cefalu W T, Kaul S, Gerstein H C, et al. Cardiovascular Outcomes Trials in Type 2 Diabetes: Where Do We Go From Here? Reflections From a Diabetes Care Editors' Expert Forum[J]. Diabetes Care, 2018, 41(1):14-31.
 Mohan A R, Ranjit U, Poongkunran M, et al. Causes and predictors of mortality in Asian Indians with and without diabetes–10 year follow-up of the Chennai Urban Rural Epidemiology Study (CURES - 150)[J]. Plos One, 2018, 13(7):e0197376.
 Chamberlain J J, Johnson E L, Leal S, et al. Cardiovascular Disease and Risk Management: Review of the American Diabetes Association Standards of Medical Care in Diabetes 2018[J]. Annals of Internal Medicine, 2018, 168(9).
 Association A D . 6. Glycemic Targets: Standards of Medical Care in Diabetes—2018[J]. Diabetes Care, 2018, 41(Suppl 1):S55.
 Ellen B, Amy H, Patty L, et al. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats[J]. Journal of the American Animal Hospital Association, 2018, 54(1):1-21.
 Association A D . 7. Obesity Management for the Treatment of Type 2 Diabetes: Standards of Medical Care in Diabetes—2018[J]. Diabetes Care, 2018, 41(Suppl 1):S65.
 Zhao L, Zhang F, Ding X, et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes [J]. Science, 2018, 359(6380):1151-1156.
 Ola S H, Egede L E, Joelle A K, et al. Psychometric properties of the Arabic version of the 12-item diabetes fatalism scale[J]. Plos One, 2018, 13(1):e0190719.
 Bingley P J, Wherrett D K, Shultz A, et al. Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes[J]. Diabetes Care, 2018, 41(4):653-661.
 Bethany W, Rebholz C M, Sang Y, et al. Diabetes and Trajectories of Estimated Glomerular Filtration Rate: A Prospective Cohort Analysis of the Atherosclerosis Risk in Communities Study[J]. Diabetes Care, 2018, 41:dc180277.
 Liang K, Ou X, Huang X, et al. Agenesis of the dorsal pancreas: a rare cause of insulin-dependent diabetes without abdominal pain[J]. Medicine, 2018, 97(9):e0046.