Academic Journal of Medicine & Health Sciences, 2021, 2(1); doi: 10.25236/AJMHS.2021.020110.
Yue Deng1, Fangyu Qu2, Zi Wang3, Wenxuan Xia4, Yuchen Xing5
1Tianjin University of Science and Technology, Tianjin, China
2The Affiliated High School to Hangzhou Normal University, Hangzhou, Zhejiang, China
3Beijing National Day School, Beijing ,China
4Liaoning Shihua University, Fushun, Liaoning,China
5BASIS International School Hangzhou, Hangzhou, Zhejiang, China
These authors contributed equally to this work
Diabetes has become a global chronic disease and alpha-glucosidase inhibitors is an effective ways of treating it. Flavonoids are a group of substances in mulberry leaves that have α-glucosidase inhibitory properties and can reduce blood glucose concentrations effectively. In this paper, flavonoids from mulberry leaves fermented by Eurotium cristatum CY-1 will be used to investigate their inhibitory properties on α-glucosidase. The results indicated that the fermentation would increase the total flavonoid content of mulberry leaves by 196.7%. Meanwhile, the α-glucosidase inhibition efficiency of flavonoids extracted from the fermented mulberry leaves was also enhanced under the same concentration. The IC50 values of the flavonoids extracted from 8 d fermented mulberry leaves and the unfermented mulberry leaf was 4.14 μg/mL and 10.26 μg/mL, respectively. This article will provide a reference for using microbial fermentation to enrich active ingredients of functional Chinese medicine herbs.
Mulberry leaves, Flavonoid, α-Glucosidase Inhibitory Activity, Eurotium cristatum, Microbial fermentation, Diabetes
Yue Deng, Fangyu Qu, Zi Wang, Wenxuan Xia, Yuchen Xing. Effect of Eurotium cristatum fermentation on the α-glucosidase inhibitory activity of mulberry leaves flavonoid extract. Academic Journal of Medicine & Health Sciences (2021) Vol. 2, Issue 1: 55-61. https://doi.org/10.25236/AJMHS.2021.020110.
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