Fan Ding1, Juntao Ran2, Ziying Dai2, Qiulan Wang3
1Teaching Experiment and Training Center, Gansu University of Chinese Medicine, Lanzhou City 730000, China
2Department of Radiotherapy, the First Hospital of Lanzhou University, Lanzhou City 730000, China
3Department of Diagnostics, Gansu University of Chinese Medicine, Lanzhou City 730000, China
Due to the characteristics of dietary structure, esophageal cancer is a malignant tumor of human digestive system with high incidence, while esophageal cancer is a heterogeneous malignant tumor with high mortality and can not be treated early. Although there are many diagnostic methods at present, the side effects are great and have a great impact on the body. Its development is mainly affected by factors such as immune dysfunction, antioxidant system damage and apoptosis. In recent years, clinical studies have shown that the study of lymph tissue infiltration, proliferation and differentiation has an important contribution to cancer. Heavy ion beam radiation is an important targeted therapy and has broad prospects. This paper mainly studied the expression and functional changes of hepatoma cells and lymphocytes induced by heavy ion radiation. Firstly, the concept, characteristics and characteristics of heavy ion beam radiation were introduced. Then, the tumor infiltrating lymphocytes of esophageal cancer were studied. Then, the expression and functional changes of tumor infiltrating lymphocytes of esophageal cancer induced by heavy ion radiation were observed. Finally, the experimental results show that heavy ion beam radiation has a strong ability to inhibit the proliferation of tumor infiltrating cells. The inhibitory effect of heavy ion beam irradiation on the proliferation of tumor infiltrating cells was positively correlated with dose time (P < 0.05). The invasion rate of cancerous cells was different between the two groups in different environments. Under the irradiation of heavy ion beam radiation, the invasion and metastasis rate of cancer cells in the experimental group was maintained at 0.1%. At the same time, the metastasis rate of the control group was the highest at 0.95% without the interference of heavy ion beam radiation.
Heavy Ion Beam Radiation, Esophageal Cancer, Tumor, Invasive Lymphocytes, Cancerous Expression
Fan Ding, Juntao Ran, Ziying Dai, Qiulan Wang. Changes of Expression and Function of Tumor Infiltrating Lymphocytes in Esophageal Cancer Induced by Heavy Ion Beam Radiation. International Journal of Frontiers in Medicine (2021), Vol. 3, Issue 5: 21-26. https://doi.org/10.25236/IJFM.2021.030503.
 Sha Z , Hong Y M , Zhang J , et al. Changes in Indoleamine 2,3-Dioxygenase 1 Expression and CD8+ Tumor-Infiltrating Lymphocytes after Neoadjuvant Chemoradiation Therapy and Prognostic Significance in Esophageal Squamous Cell Carcinoma[J]. International Journal of Radiation Oncology*Biology*Physics, 2020, 108( 1):286-294.
 Katsuhiko S , Riki O , Shinsuke S , et al. Prognostic value of Cox-2 and PD-L1 expression and its relationship with tumor-infiltrating lymphocytes in resected lung adenocarcinoma[J]. Cancer Management & Research, 2017, 9: 741-750.
 Zhu X , Zhang Q , D Wang, et al. Expression of PD-L1 Attenuates the Positive Impacts of High-level Tumor-infiltrating Lymphocytes on Prognosis of Triple-negative Breast Cancer[J]. Cancer Biology & Therapy, 2019:1-8.
 Bianchini G , Smart C , Mansutti M , et al. Modulation by treatment of tumor infiltrating lymphocytes (TILs) and PDL1 expression in triple-negative breast cancer in the ETNA trial[J]. Journal of Clinical Oncology, 2020, 38(15_suppl):555-555.
 Chen K , Zhu Z , Nan Z , et al. Tumor-Infiltrating CD4+ Lymphocytes Predict a Favorable Survival in Patients with Operable Esophageal Squamous Cell Carcinoma[J]. Medical Science Monitor International Medical Journal of Experimental & Clinical Research, 2017, 23:4619-4632.
 Bai S , Yang X , Zhang N , et al. Function of tumor infiltrating lymphocytes in solid tumors - a review[J]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2019, 35(12): 2308-2325.
 Okugawa Y , Toiyama Y , Ohi M , et al. Comment on "Prognostic Nutritional Index, Tumor-infiltrating Lymphocytes, and Prognosis in Patients With Esophageal Cancer"[J]. Annals of surgery, 2019, 270(6):e104-e105.
 Kim J Y , Heo S H , Choi S K , et al. Glutaminase expression is a poor prognostic factor in node-positive triple-negative breast cancer patients with a high level of tumor-infiltrating lymphocytes[J]. Virchows Archiv, 2017, 470(4):381-389.
 Linette G P, Carreno B M. tumor infiltrating lymphocytes in the checkpoint inhibitor era [J]. Current psychological malignancy reports, 2020, 2019,14 (4): 286-291
 Andres f h, Valerie m, Yuri F, et al. Relationship of infiltrating internal T lymphocytes in the diagnosis of oral lichen plans versus, oral veterinary dysplasia: a pilot study [J]. Oral surgery, oral medicine, oral pathology and oral radiology, 2020, 2019127 (6): e123-e135
 Klampatsa A , Shaun M. O’Brien, Thompson J C , et al. Phenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes[J]. OncoImmunology, 2019, 8(9):1-12.
 Schirosi L , Saponaro C , Giotta F , et al. Tumor Infiltrating Lymphocytes and NHERF1 Impact on Prognosis of Breast Cancer Patients - ScienceDirect[J]. Translational Oncology, 2020, 13(2):186-192.