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International Journal of Frontiers in Medicine, 2021, 3(5); doi: 10.25236/IJFM.2021.030503.

Changes of Expression and Function of Tumor Infiltrating Lymphocytes in Esophageal Cancer Induced by Heavy Ion Beam Radiation


Fan Ding1, Juntao Ran2, Ziying Dai2, Qiulan Wang3

Corresponding Author:
Qiulan Wang

1Teaching Experiment and Training Center, Gansu University of Chinese Medicine, Lanzhou City 730000, China

2Department of Radiotherapy, the First Hospital of Lanzhou University, Lanzhou City 730000, China

3Department of Diagnostics, Gansu University of Chinese Medicine, Lanzhou City 730000, China


Due to the characteristics of dietary structure, esophageal cancer is a malignant tumor of human digestive system with high incidence, while esophageal cancer is a heterogeneous malignant tumor with high mortality and can not be treated early. Although there are many diagnostic methods at present, the side effects are great and have a great impact on the body. Its development is mainly affected by factors such as immune dysfunction, antioxidant system damage and apoptosis. In recent years, clinical studies have shown that the study of lymph tissue infiltration, proliferation and differentiation has an important contribution to cancer. Heavy ion beam radiation is an important targeted therapy and has broad prospects. This paper mainly studied the expression and functional changes of hepatoma cells and lymphocytes induced by heavy ion radiation. Firstly, the concept, characteristics and characteristics of heavy ion beam radiation were introduced. Then, the tumor infiltrating lymphocytes of esophageal cancer were studied. Then, the expression and functional changes of tumor infiltrating lymphocytes of esophageal cancer induced by heavy ion radiation were observed. Finally, the experimental results show that heavy ion beam radiation has a strong ability to inhibit the proliferation of tumor infiltrating cells. The inhibitory effect of heavy ion beam irradiation on the proliferation of tumor infiltrating cells was positively correlated with dose time (P < 0.05). The invasion rate of cancerous cells was different between the two groups in different environments. Under the irradiation of heavy ion beam radiation, the invasion and metastasis rate of cancer cells in the experimental group was maintained at 0.1%. At the same time, the metastasis rate of the control group was the highest at 0.95% without the interference of heavy ion beam radiation.


Heavy Ion Beam Radiation, Esophageal Cancer, Tumor, Invasive Lymphocytes, Cancerous Expression

Cite This Paper

Fan Ding, Juntao Ran, Ziying Dai, Qiulan Wang. Changes of Expression and Function of Tumor Infiltrating Lymphocytes in Esophageal Cancer Induced by Heavy Ion Beam Radiation. International Journal of Frontiers in Medicine (2021), Vol. 3, Issue 5: 21-26. https://doi.org/10.25236/IJFM.2021.030503.


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