Shaopeng Wang, Guangyuan Yang
Department of Cardiology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, 154000, China
Lycium barbarum is a kind of traditional Chinese medicine. Lycium barbarum tastes sweet and juicy with many benefits such as nourishing liver and kidney, improving eyesight, delaying aging, etc. Lycium barbarum polysaccharide (LBP) is the main active ingredient of Lycium barbarum which has been widely used in the treatment of cardiovascular diseases in China. It has many biological activities such as anti-oxidation, anti-aging, relieving body fatigue, regulating blood lipid and blood glucose. Recent studies on LBP have shown that LBP is involved in cardiac protection through various mechanisms such as blocking l-type calcium channel, antioxidant reaction, improving myocardial fibrosis, inhibiting apoptosis, and anti-cytotoxicity. In this paper, the relevant research contents are summarized in order to provide reference for clinical research.
Lycium barbarum polysaccharide, Cardiomyocytes, Cardiacprotection, Apoptosis, Fibrosis, Signaling pathways
Shaopeng Wang, Guangyuan Yang. Current Situation of Protective Effect of Lycium Barbarum Polysaccharide on Cardiac. International Journal of Frontiers in Medicine (2021), Vol. 3, Issue 5: 46-51. https://doi.org/10.25236/IJFM.2021.030507.
 Wenli S, Shahrajabian MH, Qi C. Health benefits of wolfberry (Gou Qi Zi, Fructus barbarum L.) on the basis of ancient Chineseherbalism and Western modern medicine [J]. Avicenna J Phytomed, 2021, 11 (2): 109-119.
 Tian X, Liang T, Liu Y, et al. Extraction, Structural Characterization, Studies on Polysaccharides from Lycium Barbarum [J]. Biomolecules, 2019, 9(9): 389-406.
 Jin M, Huang Q, Zhao K, et al. Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L [J]. Int J Macromol, 2013, 54(1):16-23.
 Xia G, Xin N, Liu W. Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway [J]. Mol Med Rep, 2014, 9(4): 1237-1241.
 Varoni MV, Pasciu V, Gadau SD, et al. Possible antioxidant effect of Lycium barbarum polysaccharides on hepatic cadmium-induced oxidative stress in rats [J]. Environ Sci Pollut Res Int, 2017, 24(3): 2946-2955.
 Zhu J, Liu W, Yu J, et al. Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L [J]. Carbohydr Polym, 2013, 98 (1): 8 to 16.
 Tang WM, Chan E, Kwok CY, et al. A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit [J]. Inflammopharmacology, 2012, 20 (6): 307-314.
 Li SY, Yang D, Yeung CM, et al. Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury [J]. PLoS One, 2011, 6 (1): e16380.
 Bo R, Zheng S, Xing J, et al. The immunological activity of Lycium barbarum polysaccharides liposome in vitro and adjuvanticity against PCV2 in Int J Macromol, 2016, 85(1): 294-301.
 Li Q, Zhang Z, Li H, et al. Lycium barbarum polysaccharides protects H9c2 cells from hypoxia-induced injury by down-regulation of miR-122 [J]. Biomed Pharmacother, 2019, 110(1): 20-28.
 Liang Q, Zhang Y, Zeng M, et al. The role of IP3R-SOCCs in Cr(vi)-induced cytosolic Ca2+ overload and apoptosis in L-02 hepatocytes [J]. Toxicol Res (Camb), 2018, 7 (3): 521-528.
 Xiao Yuanyuan, Yin Xiaochen, Zeng Ming. Research progress on molecular mechanism of heavy metal induced calcium overload and apoptosis [J]. Practical Preventive Medicine, 2020, 27(02): 252-257.
 XU Shunlin, Huang Jun, TIAN Gengyuan, et al. Effects of lycium wolfberry peptide on free calcium concentration in neonatal myocardial cells of hypoxia rats [J]. Chinese Journal of Clinical Rehabilitation, 2005, 9(11): 62-64.
 LIU Miao, TANG Qizhu, Wang Xiaoling, et al. Effects of lycium barbarum polysaccharide (LBP) on l-type calcium current in rat ventricular myocytes [J]. J Wuhan univ med, 2009, 30(01): 57-60.
 Zhou Xin, YU Rui, Lin Ping. Effects of lycium barbarum polysaccharide (LBP) on myocardial ischemia in rats with myocardial infarction [J]. Chinese Journal of Traditional Chinese Medicine, 201, 39(04): 219-223.
 Lu SP, Zhao PT. Chemical characterization of Lycium barbarum polysaccharides and their reducing myocardial injury in ischemia/reperfusion of rat heart [J]. Int J Biol Macromol, 2010, 47(5): 681-684.
 Hou YM, Wang J, Zhang XZ. Lycium barbarum polysaccharide exhibits cardioprotection in an experimental model of ischemia-reperfusion damage [J]. Mol Med Rep, 2017, 15(5):2653-2658.
 Wang Yucai, Zhang Yutao, Wang Jiajun. Effects of lycium barbarum polysaccharide on myocardial ischemia reperfusion injury in rats [J]. Shandong medicine, 2013, 53(05): 34-35. (In Chinese)
 Li Lifang, DU Juan, Xue Hua, et al. Effects of lycium barbarum polysaccharide on myocardial apoptosis in rats with myocardial infarction [J]. Journal of guangxi medical university, 2018, 40(02): 97-99.
 Pan H, Niu L, Wu Y, et al. Lycium barbarum polysaccharide protects rats and cardiomyocytes against ischemia/reperfusion injury via Nrf2 Activation through inhibition by autophagy [J]. Mol Med Rep, 2021, 24(5): 778-792.
 Han Bing, Wu Qi, Chen Ying. Effects of Lycium barbarum polysaccharide on sympathetic nerve remodeling after myocardial infarction [J]. Journal of Heze Medical College, 201, 33(02): 3-4.
 QI Guoxue, Cui Ying, Yan Ning, et al. Homocysteine mediated apoptosis of APOE-/- mouse myocardial cells by endoplasmic reticulum stress and the intervention of Lycium barbarum polysaccharide [J]. Journal of ningxia medical university, 2019, 41(02): 109-113.
 Meng Lili. Lycium barbarum polysaccharide improves myocardial fibrosis in chronic heart failure rats by TGFβ1/Smad3 signaling pathway [J]. Chinese Journal of Experimental Diagnostics, 201, 25(02): 242-247.
 LIU Xinyan, ZHENG Ping, Yan Lin, et al. Protective effect of Lycium barbarum Polysaccharide on isoprenaline induced heart failure in rats and its mechanism [J]. Journal of ningxia medical university, 2011, 33(7): 601-604.
 Pop C, Berce C, Ghibu S, et al. Effects of Lycium barbarum L. Polysaccharides on Inflammation and Oxidative Stress Markers in a Pressure Overload-Induced Heart Failure Rat Model [J]. Molecules, 2020, 25(3):466-477.
 Zhang R, Xu Y, Niu H, et al. Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction Study on the expression of micrornA-1 [J]. Cell Mol Med, 2018, 22(10):4830-4839.
 Liu Qianqian. Effects of lycium barbarum polysaccharide (LBP) on diabetic cardiomyopathy in rats [J]. Jinzhou Medical University, 2019.
 Zhou Guoliang, XIN Yanfei, Xie Fang, et al. Protective effect of lycium barbarum polysaccharide on H9c2 injury induced by doxorubicin [J]. China journal of traditional Chinese medicine, 2011, 29(07): 1500-1502.
 Xin YF, Wan LL, Peng JL, et al. Alleviation of the acute doxorubicin-induced cardiotoxicity by Lycium barbarum polysaccharides through the suppression of oxidative stress [J]. Food Chem Toxicol, 2011, 49(1):259-264.
 Xin Y, Zhang S, Gu L, et al. Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute Biol Pharm Bull, 2011, 34(10):1523-1526. (In Chinese with English abstract)
 Yu Ning, Yang Fang, Leng Xue, et al. Lycium barbarum polysaccharide (LBP) regulates PI3K/Akt/eNOS signaling pathway to promote antioxidant activity in ovariectomized rat myocardium [J]. Chinese journal of pathophysiology, 2016, 32(08): 1370-1375.
 Yu N, Song N, Liu CY, et al. The estrogen like protective effect of Lycium barbarum polysaccharides in reducing oxidative stress on myocardial Study on the influence of different treatments on the apoptosis of rats [J]. Mol Med Rep, 2019, 19(3):2271-2278.