Chronic musculoskeletal disease is the most common disease category in orthopedics, and belongs to the categories of "bone paralysis", "bone impotence", "neck and shoulder pain" or "low back pain" in Chinese medicine. "The disease involves several internal organs and many kinds of internal organs. The disease involves several internal organs and many kinds of essence substances, and is always the evidence of deficiency of the original, impotence and paralysis, with deficiency of qi and blood inside and external evil attacking outside, deficiency of liver, spleen and kidney as the root cause of the disease, wind, cold and dampness attacking the body, and phlegm and stasis blocking the flow of qi and blood. This paper summarizes and discusses the etiology and pathogenesis from several TCM perspectives, aiming to better guide people to understand chronic tendon and bone diseases and provide new directions and ideas for clinical prevention and treatment.

Xiaokang Han, Feng Yang. An Analysis of the Etiology and Pathogenesis of Chronic Musculoskeletal Diseases Based on the Foundation of Chinese Medicine. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 1: 32-39. https://doi.org/10.25236/IJFM.2022.040106.

[1] Wang Congjun, Liang Qianqian, Tang Dezhi, et al. Academic thoughts and research on Shi Qi's prevention and treatment of chronic tendon and bone diseases [J]. Shanghai Journal of Traditional Chinese Medicine, 2017, 51(04): 1-5.

[2] Yang F, Li WX, Yang J, et al. Experience of famous Chinese medicine practitioner Prof. Li Yanmin in the treatment of chronic tendon and bone diseases using the Tongluo method [J]. Chinese Journal of Traditional Chinese Medicine Orthopedics and Traumatology, 2020, 28(10): 83-84.

[3] Li Xiaofeng, Wang Congjun, Ye Xiulan, et al. Shi QI's experience in treating chronic musculoskeletal disorders with creams [J]. Journal of Traditional Chinese Medicine, 2012, 53(18): 1543-1545.

[4] Wang Xiang, Shi Yinyu. Clinical thinking of Professor Shi Yinyu in the treatment of degenerative osteoarthrosis [J]. Chinese Journal of Traditional Chinese Medicine and Orthopedics, 2021, 29(03): 79-80+84.

[5] Cao BX, Lin HAQ, Wu Y, et al. Chronic pain classification catalog and definition [J]. Chinese Journal of Pain Medicine, 2021, 27(01): 2-8.

[6] Ma YZ, Wang YP, Liu Q, et al. Chinese guidelines for the diagnosis and treatment of osteoporosis in the elderly (2018) [J]. Chinese Journal of Gerontology, 2019, 39(11): 2557-2575.

[7] Chinese pain expert consensus on the diagnosis and treatment of lumbar disc herniation [J]. Chinese Journal of Pain Medicine, 2020, 26(01): 2-6.

[8] Liu Pei-Tai, Zhang Jun, Wu Shuo-Zhu, Yang YF. Discussion on the pathogenesis of cervical vertigo [J]. Chinese Journal of Traditional Chinese Medicine Orthopedics and Traumatology, 2019, 27(06): 13-17+22.

[9] Lan packing, Yao M, Wang J, et al. Overview of research on different TCM evidence-based typologies of cervical spondylosis [J]. Chinese Journal of Traditional Chinese Medicine Orthopedics and Traumatology, 2015, 23(04): 67-70.

[10] Lu C, Tang Z Y, Ye X L, Shi QI, Wang C J. Research progress on the pathogenesis of cervical spondylosis and traditional manipulation treatment [J]. Chinese Journal of Traditional Chinese Medicine Orthopedics and Traumatology, 2011, 19(01): 61-64.

[11] Guidelines for the diagnosis and treatment of osteoarthritis (2018 edition) [J]. Chinese Journal of Orthopaedics, 2018, 38(12): 705-715.

[12] Guidelines for the diagnosis and treatment of osteoarthritis [J]. Chinese Journal of Rheumatology, 2010(06): 416-419.

[13] Xia Weibo, Zhang Zhenlin, Lin Hua, Jin Xiaolan, Yu Wei, Fu Qin. Guidelines for the diagnosis and treatment of primary osteoporosis (2017) [J]. Chinese Journal of Osteoporosis, 2019, 25(03): 281-309.

[14] Wang Huan, Sun He, Zhang Yaonan, et al. Survey on the prevalence of primary knee osteoarthritis by compartment in people over 40 years old in China [J]. Chinese Journal of Bone and Joint Surgery, 2019, 12(07): 528-532.

[15] Kong Y, Wang Guodong, Meng Chunyang. Relationship between serum inflammatory factors and angiogenic factors in osteoarthritis of the knee joint [J]. Chinese Journal of Orthopaedic Surgery, 2019, 27(10): 916-920.

[16] Zhang ZB, Shi DL, Du XZ, et al. The efficacy of adding An-Yuan Tang in the treatment of early to mid-stage ankylosing spondylitis and the effects on serum inflammatory factors, immune function and bone metabolic indexes in patients [J/OL]. Chinese Journal of Experimental Formulary: 1-5 [2021-05-05].

[17] Wang Mina, Liu Lu, Zhao Luopeng, et al. Research progress of inflammatory factors and signaling pathways in knee osteoarthritis [J]. China Orthopaedic Injury, 2020, 33(04): 388-392.

[18] Shi QI, Wang YONGJUN. Research on chronic musculoskeletal diseases and Chinese medicine prevention and treatment [J]. Geriatrics and Health Care, 2015, 21(02): 65-67.

[19] Cai Yi, Zhao Jirong, Zhu Changping, et al. Exploring the pathogenesis and clinical treatment of osteoporosis secondary to spinal cord injury based on the theory of "the kidney is the master of bone and marrow production" [J]. Chinese Journal of Osteoporosis, 2021, 27(01): 131-134+152.

[20] Feng Xuzhi, Wu Jilei, Ren Yanling. Analysis of the pathological changes of postmenopausal osteoporosis based on the theory of "essence" and "yin and yang" of the kidney [J]. Chinese Journal of Osteoporosis, 2021, 27(03): 418-420+425.

[21] Di Guixin, Yang Fang. Analysis of the pathogenesis of osteoporosis from the five organs of Chinese medicine [J/OL]. Journal of Liaoning University of Traditional Chinese Medicine: 1-9 [2021-05-05].

[22] Sun Yueli, Yao Min, Cui Xuejun, et al. Chinese medical understanding and modern understanding of chronic musculoskeletal disorders [J]. Journal of Traditional Chinese Medicine, 2014, 55(17): 1447-1451.

[23] Liu Zhengtang, Liu Mengyang, Huang Yue, et al. Discussion on the advantages and mechanisms of action of the "spleen deficiency-kidney deficiency-blood stasis" theory in the treatment of osteoporosis [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2021, 04: 11-14

[24] Shi QI, Wang YONGjun, Zhou RE, et al. Application and development of qi-blood theory in delaying intervertebral disc degeneration process [J]. Chinese Journal of Orthopaedics and Traumatology, 2006(S2): 190-192.

[25] Sang X.W., Du G.Q., Chen B., Zhan H.S. Zhan Hongsheng's experience in identifying and treating osteoporosis [J]. Shanghai Journal of Traditional Chinese Medicine, 2019, 53(12): 24-26.

[26] Wang Congjun,Liang Qianqian,Cui Xuejun,et al. Application and development of the method of harmonizing qi and blood to prevent and treat chronic tendon and bone diseases [J]. Shanghai Journal of Traditional Chinese Medicine, 2017, 51(06): 1-4+12.

[27] He LJ, Zhao YX, Li HC, Wang DW, Wen CP. Discussion on the Chinese medicine treatment of rheumatism from wind evil [J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2017, 41(08): 661-663.

[28] Shen Shiwei. Rumination on the treatment of chronic low back pain from wind evil--with three experimental cases [J]. Jiangsu Traditional Chinese Medicine, 2013, 45(06): 54-55.

[29] Wang Lumin. Analysis of ancient Chinese medical literature based on the theory of cold evil to discuss the importance of treating cold evil and the principles of treatment [J]. Chinese Journal of Traditional Chinese Medicine, 2018, 33(08): 3641-3643.

[30] Jia Z-X. An analysis of "Dampness is better than moistening" [J]. Journal of Beijing University of Traditional Chinese Medicine, 2020, 43(09): 785-788.

[31] Tang Xuan, Zhao Yue, Huang Leun Yue. The treatment of rheumatoid arthritis from the theory of "dampness" [J]. Jiangsu Traditional Chinese Medicine, 2021, 53(03): 14-16.

[32] Lu Hongrong, Du Song, Hu Jingqing. A study on the origin of the theory of the treatment of phlegm and blood stasis [J]. Journal of Traditional Chinese Medicine, 2015, 56(10): 811-815.

[33] Qiao JL, Diao EJ. Identification and treatment of paralysis from phlegm and turbidity [J]. Shandong Journal of Traditional Chinese Medicine, 2013, 32(09): 619-620.

[34] Xu Zhengjin, Chen Jinchun, Qiu Mingshan, et al. A brief discussion on the pathogenic role of phlegm stasis in rheumatoid arthritis [J]. Liaoning Journal of Traditional Chinese Medicine, 2018, 45(06): 1167-1170.

[35] Yin H-B, Shi B, Zhang J-H. Identification and treatment of gout based on phlegm and turbidity causing paralysis [J]. Chinese Journal of Traditional Chinese Medicine Information, 2012, 19(08): 94-95.

[36] Li Xiaofeng, Tao Wu, Mo Wen, et al. On the identification and treatment of chronic tendon and bone diseases from paralysis [J]. Shanghai Journal of Traditional Chinese Medicine, 2017, 51(03): 1-4.

[37] Jing Shaobo,Zhang Jianping,Li Jianguo,et al. Exploring the understanding of the pathogenesis and treatment progress of osteoporosis in Chinese medicine based on the theory of blood stasis in Chinese medicine [J]. Chinese Journal of Osteoporosis, 2021, 27(02): 275-278.

[38] Jiang Yan. Preliminary discussion on the evidence of stasis of blood in the Medical Lin Correction [J]. Journal of Beijing University of Traditional Chinese Medicine, 2014, 37(03): 152-155+164.

[39] Ding Juxian, Xie Xingwen, Xu Wei, et al. The relationship between "stasis" and bone malignant tumors from the three organs of Chinese medicine: lung, spleen and kidney [J/OL]. Chinese Journal of Basic Chinese Medicine: 1-6 [2021-04-06].

[40] Li XF, Wu Tao, Mo W, Wang YJ, Hu ZJ, Shi QI. On the identification and treatment of chronic tendon and bone diseases from paralysis [J]. Shanghai Journal of Traditional Chinese Medicine, 2017, 51(03): 1-4.

[41] Li Xiaofeng, Mo Wen, Hu Zhijun,et al. Shi Qi diagnosis and treatment of chronic tendon and bone disease ideas and methods [J]. Journal of Traditional Chinese Medicine, 2017, 58(17): 1453-1457.

[42] Jiang Jianchun, Qiu Huahua, Wang Ao Ming, Wu Junhao, Li Hogang, Shi Yangshan. Professor Shi Yangshan's experience in the treatment of chronic tendon and bone diseases [J]. Chinese Journal of Traditional Chinese Medicine Orthopedics and Traumatology, 2014, 22(02): 67-69.

[43] Yuan Wei'an, Zhan Hongsheng, Du Guoqing. On the clinical significance of the concept of "the tendon is the master of the bone" in the diagnosis and treatment of chronic tendon and bone diseases and injuries [J]. Shanghai Journal of Traditional Chinese Medicine, 2019, 53(09): 12-15.

[44] Song YJ, Li XF, Bao JM, Zhou LY, Cui XJ, Shi QI, Wang YJ. Discussion on the diagnosis and treatment of chronic musculoskeletal disorders from the perspective of great health [J]. Chinese Journal of Traditional Chinese Medicine, 2020, 35(02): 543-545.

[45] Li X. H. A new strategy for the prevention and treatment of chronic tendon and bone diseases based on the idea of neutralization [J]. Chinese Journal of Traditional Chinese Medicine, 2020, 35(04): 1651-1653.