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International Journal of Frontiers in Medicine, 2022, 4(4); doi: 10.25236/IJFM.2022.040406.

A Meta-Analysis of Serum Vitamin D Deficiency in Graves' Ophthalmopathy


Shipeng Wang1, Yongwei Yu2, Jinze Yang3

Corresponding Author:
Shipeng Wang

1Capital Medical University Forth Clinical School, Beijing, 100176, China

2School of Electronic, Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200241, China

3College of Electronic and Information Engineering, Tongji University, Shanghai, 201804, China


Objective: to systematically evaluate the status of serum vitamin D deficiency in patients with Graves’ ophthalmopathy (GO). Methods: the case-control studies, cohort studies and randomized controlled trials associated with Graves’ ophthalmopathy were searched in PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science. The literatures were screened according to inclusion, exclusion criteria and quality evaluation, and the extracted data were analyzed by Meta with ReviewManager5.4 software. Results: 5 studies were included, and the number of cases included in the study was 887. The results of Meta-analysis showed that compared with the control group, the level of vitamin D in the Graves’ ophthalmopathy group was lower than that in the control group (MD=-8.22, 95%CI: -15.75~-11.45, P < 0.001). Conclusion: the decrease of serum vitamin D level is related to the diagnosis of GO. Assessment and supplementation of vitamin D levels may be an important supplement for early treatment of GD patients. Future studies should include longitudinal studies and prospective clinical trials to further explore the mechanisms of observed associations. In view of the small number of included studies, the above conclusions need to be confirmed by more high-quality randomized studies.


Graves’ ophthalmopathy; Vitamin D; Meta-analysis

Cite This Paper

Shipeng Wang, Yongwei Yu, Jinze Yang. A Meta-Analysis of Serum Vitamin D Deficiency in Graves' Ophthalmopathy. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 4: 28-33. https://doi.org/10.25236/IJFM.2022.040406.


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