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International Journal of Frontiers in Medicine, 2022, 4(4); doi: 10.25236/IJFM.2022.040410.

Progress in the correlation of mitochondrial dysfunction and diabetic kidney disease


Zhang Shuyan1, Zhang Huan1, Zou Chunbo2

Corresponding Author:
Zou Chunbo

1Nantong University, Medical School, Nantong, Jiangsu, 226000, China

2Taizhou City People's Hospital, Taizhou, Jiangsu, 225300, China


Diabetic kidney disease(DKD) is the most common complication of diabetes prevalence rate increased year by year, kidney as one of the body organs consumption, need to provide enough mitochondria ATP to maintain the normal physiological function, sustained high blood sugar levels induced by activating multiple pathways mitochondria damage, cause the energy imbalance, ATP production, to its negative effects, in recent years, Mitochondrial dysfunction has been concerned in the occurrence and development of kidney diseases, and is considered to be a key factor involved in the pathogenesis of diabetic kidney disease. In this paper, the role of mitochondrial structure and dysfunction in the progression of DKD is described, providing a theoretical basis for controlling the progression of DKD.


Mitochondrial structure; mitochondrial dysfunction; diabetic kidney disease

Cite This Paper

Zhang Shuyan, Zhang Huan, Zou Chunbo. Progress in the correlation of mitochondrial dysfunction and diabetic kidney disease. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 4: 54-60. https://doi.org/10.25236/IJFM.2022.040410.


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