Stroke is one of the diseases with high incidence of cardiovascular and cerebrovascular diseases in the world. Its disability rate ranks first in cardiovascular and cerebrovascular diseases. The pathophysiology of this disease is that cerebral blood circulation leads to cerebral ischemia and hypoxia, which leads to softening and necrosis of brain tissue. Hif-1 α is a nuclear transcription factor produced by the body under hypoxia, which activates a series of target genes to produce hypoxia tolerance response and maintain environmental balance in the body. Hif-1 α is a nuclear protein produced under hypoxia. By regulating downstream cells, it can promote the formation of new blood vessels, resist neuronal apoptosis, and alleviate ischemia and hypoxia injury. Hif-1 α is a key hypoxia receptor, which can be expressed rapidly in brain hypoxia, and its level is closely related to hypoxia. The role of hypoxia-inducible factor-1 α (HIF-1α) in ischemic stroke has become a research hotspot in recent years.

Yuehang Zhang, Jiahao Xue, Xu Deng. Study on the Effects of HIF-1α on Ischemic Stroke. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 6: 33-35. https://doi.org/10.25236/IJFM.2022.040606.

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