With the progress of the times and the fast-paced lifestyle, the key pathogenesis of diabetes has gradually changed. According to the clinical manifestations of modern diabetic patients, Gao etal. proposed the theory of damp-heat dissipation [3]. At the same time, according to clinical observation [4], patients with type 2 diabetes often accompanied by varying degrees of insomnia symptoms. Huanglian Wendan Decoction has now become a common prescription for the treatment of type 2 diabetes mellitus complicated with insomnia of damp-heat syndrome. This paper reviews the recent research progress of Huanglian Wendan Decoction in the treatment of diabetes mellitus complicated with insomnia by retrieving relevant literature in recent years, and provides a basis for further in-depth study and rational drug use.

Zefang Zhou, Dan Guo, Jiajia Zhan, Lu Shen. Research Progress of Huanglian Wendan Decoction in Treating Diabetes Complicated with Insomnia. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 7: 45-48. https://doi.org/10.25236/IJFM.2022.040708.

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[2] Diabetes Society of Chinese Medical Association. Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2020 Edition) [ J]. International Journal of Endocrine Metabolism, 202,41 (05): 482-548 

[3] Guo Meiling, Zhao Meiyi, Gao Tianshu. Type 2 diabetes with damp-heat trapped spleen syndrome etiology and pathogenesis [ J]. Practical Journal of Internal Medicine of Traditional Chinese Medicine, 2020,34 (05): 141-143.

[4] Zhao Jing, Zhang Jian. Observation on the efficacy of Huanglian Wendan Decoction in the treatment of type 2 diabetes with insomnia [ J]. Study on the combination of Chinese and Western medicine, 2016, 8 (04): 176 – 178. 

[5] Wang Mingkun, Cheng Li, Zhao Xin, Li Ailing. Clinical study on Huanglian Wendan Decoction in the treatment of type 2 diabetes mellitus with damp-heat accumulation [ J]. Integrative Chinese and Western medicine research, 2021, 13 (06): 369 – 372. 

[6] Liu Li, Yang Yueguang, Zou Guoliang, Wu Xia, Li Na, Han Yubo. Effect of Jiawei Huanglian Wendan Decoction on cardiovascular risk factors in patients with metabolic syndrome complicated with phlegm-heat syndrome of type 2 diabetes [ J]. Chinese medicine, 2021, 16 (10): 1562 – 1566. 

[7] Zhu Jinhua, Zhou Jun, Wan Hongjiao, Sun Haoxin, Xu Jia, Gao Yuan, Zhang Yuan, Hong Yurou. Effect of Huanglian Wendan Decoction on the changes of cytokines and TLR4, NF-κB in type 2 diabetic rats [ J]. Pharmacology and clinical, 2021,37 (03): 6-11.

[8] Wang Mingkun, Cheng Li, Zhao Xin, Li Ailing. Study on the mechanism of Huanglian Wendan Decoction in the intervention of type 2 diabetes based on network pharmacology [ J]. Integrated traditional Chinese and western medicine research, 2022,14 (01): 30-36.

[9] Wei Jiaqi, Xu Juan, Lu Anming. Clinical Observation of Huanglian Wendan Decoction in the Treatment of Insomnia of Phlegm-heat Internal Disturbing Type [ J]. Chinese Community Doctor, 2022,38 (10): 70-72. 

[10] Chen Xiaoyan, Cai Zhiguo, Wang Kangfeng. Clinical observation of Huanglian Wendan Decoction in the treatment of phlegm-heat disturbance insomnia [ J]. World Journal of Sleep Medicine, 2020, 7 (12): 2064 – 2065. 

[11] Ouyang Wenhui. Clinical efficacy of Huanglian Wendan Decoction combined with western medicine in the treatment of phlegm-heat disturbance insomnia [ J]. Journal of Clinical Rational Drug Use, 2021, 14 (09): 144 – 146. 

[12] Lei Life, Han Guanxian, Guan Dongsheng, Zhao Huanghong, Mao Yarui, Li Jiazhen, Cao Yuke, Wu Shuai. Discussion on the mechanism of Huanglian Wendan Decoction in treating insomnia based on network pharmacology [ J]. Chinese convalescent medicine, 2021,30 (10): 1013-1018.

[13] Cai Zhiguo, Chen Xiaoyan, Wang Kangfeng. Effect of Huanglian Wendan Decoction on the expression of blood monoamine neurotransmitters in patients with insomnia of phlegm-heat disturbance [J]. World Journal of Sleep Medicine, 2021,8 (01): 57-58.

[14] Zhao Jing, Zhang Jian. Huanglian Wendan Decoction in the treatment of type 2 diabetes with insomnia curative effect observation [ J]. Combined traditional Chinese and western medicine research, 2016,8 (04): 176-178. 

[15] Lin. To investigate the clinical efficacy of Huanglian Wendan Decoction in the treatment of diabetes mellitus complicated with phlegm-heat disturbing heart type insomnia [ J]. Modern Chinese medicine application, 2019, 13 (24): 213 – 215. 

[16] Cheng Jiehui. Huanglian Wendan Decoction in the treatment of obese type 2 diabetes insomnia 50 cases of curative effect observation [ J]. Liaoning Journal of Traditional Chinese Medicine, 2009,36 (07): 1131-1132.