Objective: To analyze the clinical therapeutic value of amiodarone in patients with chronic heart failure complicated with chronic atrial fibrillation, and to evaluate the pharmacology of the drug. Methods: a total of 86 patients with chronic heart failure complicated with chronic atrial fibrillation admitted to our hospital from October 2019 to March 2021 were selected, and the control group received conventional treatment, including furosemide tablets, benazepril and isosorbide mononitrate sustained-release capsules, all orally administered. The observation group was treated with amiodarone on the basis of the above treatment methods, and the clinical efficacy of the two groups was evaluated. Results: Compared the data of left ventricular diameter and left ventricular ejection fraction after treatment, the observation group was better than the control group (P < 0.05);The heart rate and blood pressure of the patients before and after treatment showed that the blood pressure of the observation group was significantly higher than that of the control group, and the heart rate was lower than that of the control group, with significant differences between the groups (P < 0.05).Drug safety evaluation showed that the rate of adverse reactions in the observation group was only 16.28% (7/43), and there was no significant difference between the observation group and the control group (P > 0.05).The total effective rate in observation group was higher (P < 0.05).Conclusion: Amiodarone can improve the therapeutic effect of drugs and improve the problems of low blood pressure in patients with chronic heart failure complicated with chronic atrial fibrillation during the clinical treatment, which is a safe medication regimen and deserves attention.

Liu Jiaxin. Clinical effect and pharmaceutical study of amiodarone in the treatment of chronic heart failure complicated with chronic atrial fibrillation. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 7: 53-57. https://doi.org/10.25236/IJFM.2022.040710.

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