The incidence of premature ovarian failure is increasing year by year, which brings serious harm to women's physical and mental health. Western medicine is mostly based on hormone replacement therapy, which may increase the risk factor for vaginal bleeding and endometrial cancer with long-term use. According to Traditional Chinese Medicine, the treatment of premature ovarian failure is based on kidney tonification and treatment according to the evidence. Zuogui Pill can regulate immune factors and reproductive endocrine function, inhibit rapid apoptosis of granulosa cells, promote angiogenesis, increase local blood supply, thereby improving ovarian function, regulating menstrual status, and alleviating perimenopausal syndrome. However, a standardized and comprehensive treatment system needs to be explored in depth.

Li Yi, Xiaoping Cui, Gege Li, Mingzhu Huang, Juanjuan Zhang, Xinchun Xiao, Xia Liu. Application and Mechanism of Action of Zuogui Pill in the Treatment of Premature Ovarian Failure. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 8: 46-52. https://doi.org/10.25236/IJFM.2022.040808.

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