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International Journal of Frontiers in Medicine, 2022, 4(8); doi: 10.25236/IJFM.2022.040810.

Research Progress of M2 Macrophage


Quan Yang1,2, Yu Su1,2, Huiyu He1,2

Corresponding Author:
Huiyu He

1Department of Prosthodontics and Dental Implantology, The First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, Xinjiang 830054, China

2Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, Xinjiang 830054, China


M2 macrophages are polarized by macrophages under a variety of stimuli, including cytokines, micro-RNA and tissue microenvironment. M2 macrophages play a positive role in promoting wound healing, tissue recovery and immunosuppression, but they are also closely related to tissue and organ fibrosis and tumor occurrence and development. This article will review the research status of M2 macrophages from the aspects of the phenotype of M2 macrophages, the reasons for promoting M2 polarization of macrophages, and the significance and function of M2 macrophages. 


M2 macrophages, polarization, micro-RNA, cytokines, tissue microenvironment

Cite This Paper

Quan Yang, Yu Su, Huiyu He. Research Progress of M2 Macrophage. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 8: 60-64. https://doi.org/10.25236/IJFM.2022.040810.


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