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Academic Journal of Medicine & Health Sciences, 2022, 3(1); doi: 10.25236/AJMHS.2022.030106.

More than Guideline-Research Progress on Compliance of ARNI


Yiwen Shi

Corresponding Author:
Yiwen Shi

Shenyang Pharmaceutical University School of Pharmacy Shenyang, Liaoning, China


Aims: As a new treatment for heart failure, ARNI have a significant clinical effect. However, the prognosis of patients with heart failure after discharge is not acceptable, which is related to the compliance of ARNI. In this paper, the concept, status quo and influencing factors of ARNI were reviewed, and methods for improving patients' drug compliance were proposed. Methods and results: Through systematic retrieval of literature database MEDLINE, a total of 5 literatures on compliance of ARNI were selected for analysis, and the results showed that compliance of ARNI was between 15% and 35%. The effects of age, gender, ARNI-related economic expenditures, Patient perception of ARNI and concomitant diseases on compliance with ARNI were reviewed Conclusion: The results show that the compliance of patients with heart failure to ARNI is disappointing, and affected by many factors, resulting in a poor prognosis of patients. In the future, physicians should pay more attention to the compliance of ARNI and improve the quality of medical treatment.


ARNI, drug compliance, heart failure

Cite This Paper

Yiwen Shi. More than Guideline-Research Progress on Compliance of ARNI . Academic Journal of Medicine & Health Sciences (2022) Vol. 3, Issue 1: 32-36. https://doi.org/10.25236/AJMHS.2022.030106.


[1] Timmis (chair writing group) A, Vardas P, Townsend N, Torbica A, Katus H, De Smedt D, Gale CP, Maggioni AP, Petersen SE, Huculeci R, Kazakiewicz D, de Benito Rubio V, Ignatiuk B, Raisi-Estabragh Z, Pawlak A, Karagiannidis E, Treskes R, Gaita D, Beltrame JF, McConnachie A, Bardinet I, Graham I, Flather M, Elliott P, Mossialos EA, Weidinger F, Achenbach S, Atlas Writing Group, European Society of Cardiology. European Society of Cardiology: cardiovascular disease statistics. 2021. Eur Heart J. 2022 Feb 22; 43(8):716-799.

[2] Ambrosy AP, Mentz RJ, Fiuzat M, Cleland JGF, Greene SJ, O'Connor CM, Teerlink JR, Zannad F, Solomon SD. The role of angiotensin receptor-neprilysin inhibitors in cardiovascular disease-existing evidence, knowledge gaps, and future directions. Eur J Heart Fail. 2018 Jun; 20(6): 963-972.

[3] Connie W Tsao, Asya Lyass, Danielle Enserro, Martin G Larson, Jennifer E Ho, Jorge R Kizer, John S Gottdiener, Bruce M Psaty, Ramachandran S Vasan. Temporal Trends in the Incidence of and Mortality Associated with Heart Failure with Preserved and Reduced Ejection Fraction. JACC Heart Fail. 2018 Aug; 6(8): 678-685.

[4] Gianluigi Savarese, Johan Bodegard, Anna Norhammar, Peter Sartipy, Marcus Thuresson, Martin R Cowie, Gregg C Fonarow, Muthiah Vaduganathan, Andrew J S Coats. Heart failure drug titration, discontinuation, mortality and heart failure hospitalization risk: a multinational observational study (US, UK and Sweden). Eur J Heart Fail. 2021 Sep; 23(9): 1499-1511.

[5] Anthony P Carnicelli, Steven J Lippmann, Stephen J Greene, Robert J Mentz, Melissa A Greiner, N Chantelle Hardy, Bradley G Hammill, Xian Shen, Clyde W Yancy, Pamela N Peterson, Larry A Allen, Gregg C Fonarow, Emily C O'Brien. Sacubitril/Valsartan Initiation and Postdischarge Adherence Among Patients Hospitalized for Heart Failure. J Card Fail. 2021 Aug; 27(8): 826-836.

[6] Anthony P Carnicelli, Zhen Li, Melissa A Greiner, Steven J Lippmann, Stephen J Greene, Robert J Mentz, N Chantelle Hardy, Vanessa Blumer, Xian Shen, Clyde W Yancy, Pamela N Peterson, Larry A Allen, Gregg C Fonarow, Emily C O'Brien. Sacubitril/Valsartan Adherence and Postdischarge Outcomes Among Patients Hospitalized for Heart Failure with Reduced Ejection Fraction. JACC Heart Fail. 2021 Dec; 9(12): 876-886.

[7] Stephen J Greene, Emily C O'Brien, Robert J Mentz, Nancy Luo, N Chantelle Hardy, Warren K Laskey, Paul A Heidenreich, Chun-Lan Chang, Stuart J Turner, Clyde W Yancy, Adrian F Hernandez, Lesley H Curtis, Pamela N Peterson, Gregg C Fonarow, Bradley G Hammill. Home-Time After Discharge Among Patients Hospitalized with Heart Failure. J Am Coll Cardiol. 2018 Jun 12; 71(23): 2643-2652.

[8] Muthiah Vaduganathan, Gregg C Fonarow, Stephen J Greene, Adam D DeVore, Abhishek Kavati, Slaven Sikirica, Nancy M Albert, Carol I Duffy, C Larry Hill, J Herbert Patterson, John A Spertus, Laine E Thomas, Fredonia B Williams, Adrian F Hernandez, Javed Butler. Contemporary Treatment Patterns and Clinical Outcomes of Comorbid Diabetes Mellitus and HFrEF: The CHAMP-HF Registry. JACC Heart Fail. 2020 Jun; 8(6): 469-480.

[9] Rasmussen AA, Wiggers H, Jensen M, Berg SK, Rasmussen TB, Borregaard B, Thrysoee L, Thorup CB, Mols RE, Larsen SH, Johnsen SP. Patient-reported outcomes and medication adherence in patients with heart failure. Eur Heart J Cardiovasc Pharmacother. 2021 Jul 23; 7(4): 287-295.

[10] Davide Stolfo, Matteo Castrichini, Elena Biagini, Miriam Compagnone, Antonio De Luca, Thomas Caiffa, Alessandra Berardini, Giancarlo Vitrella, Renat. Ea Korcova, Andrea Perkan, Marco Foroni, Marco Merlo, Giulia Barbati, Francesco Saia, Claudio Rapezzi, Gianfranco Sinagra. Modifications of medical treatment and outcome after percutaneous correction of secondary mitral regurgitation. ESC Heart Fail. 2020 Aug; 7(4): 1753-1763.

[11] Jesse F Veenis, Hans-Peter Brunner-La Rocca, Gerard Cm Linssen, Peter R Geerlings, Marco Wf Van Gent, Ismail Aksoy, Liane Oosterom, Arno Hm Moons, Arno W Hoes, Jasper J Brugts, CHECK-HF investigators. Age differences in contemporary treatme. Ant of patients with chronic heart failure and reduced ejection fraction. Eur J Prev Cardiol. 2019 Sep;26(13):1399-1407.

[12] Katrin Krueger, Lea Botermann, Susanne G Schorr, Nina Griese-Mammen, Ulrich Laufs, Martin Schulzge-related medication adherence in patients with chronic heart failure: A systematic literature review. Int J Cardiol. 2015 Apr 1; 184:728-735.

[13] Muhammed T Gürgöze, Onno P van der Galiën, Marlou A M Limpens, Stefan Roest, René C Hoekstra, Arne S IJpma, Jasper J Brugts, Olivier C Manintveld, Eric Boersma. Impact of sex differences in co-morbidities and medication adherence on outcome in 25 776 heart failure patients. ESC Heart Fail. 2021 Feb;8(1):63-73.

[14] Baumhäkel M, Müller U, Böhm MInfluence of gender of physicians and patients on guideline-recommended treatment of chronic heart failure in a cross-sectional study. Eur J Heart Fail. 2009 Mar;11(3):299-303.

[15] Tromp J, Bamadhaj S, Cleland JGF, Angermann CE, Dahlstrom U, Ouwerkerk W, Tay WT, Dickstein K, Ertl G, Hassanein M, Perrone SV, Ghadanfar M, Schweizer A, Obergfell A, Lam CSP, Filippatos G, Collins SP. Post-discharge prognosis of patients admitted to hospital for heart failure by world region, and national level of income and income disparity (REPORT-HF): a cohort study. Lancet Glob Health. 2020 Mar;8(3): e411-e422.

[16] Hung CL, Chao TF, Su CH, Liao JN, Sung KT, Yeh HI, Chiang CE. Income level and outcomes in patients with heart failure with universal health coverage. J Ment Health Policy Econ. 2012 Sep; 15(3): 105-18.

[17] Michele Senni, John J V McMurray, Rolf Wachter, Hugh F McIntyre, Inder S Anand, Vincenzo Duino, Arnab Sarkar, Victor Shi, Alan Charney. Impact of systolic blood pressure on the safety and tolerability of initiating and up-titrating sacubitril/valsartan in patients with heart failure and reduced ejection fraction: insights from the TITRATION study. Eur J Heart Fail. 2018 Mar; 20(3): 491-500.