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International Journal of Frontiers in Medicine, 2022, 4(9); doi: 10.25236/IJFM.2022.040903.

Research progress of CPP-ACP promoting enamel remineralization


Jing Wang1,2, Yanli Mo1,2, Yishan Liu1,2

Corresponding Author:
Yishan Liu

1Department of Pediatric Dentistry, The First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, Xinjiang, 830054, China

2Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, Xinjiang, 830054, China


With the improvement of people's living standards and the strengthening of awareness of caries prevention and control, enamel remineralization has received extensive attention. Fluoride is a commonly used remineralization agent in clinic and life, but its remineralization process depends on calcium and phosphorus ions in saliva. Therefore, several new remineralizers have been introduced to supplement and improve the repair ability of fluoride to dental minerals, such as bioactive glass, nano hydroxyapatite, casein phosphopeptide amorphous calcium phosphate (CPP-ACP), which can promote enamel remineralization to a certain extent. Casein phosphopeptide amorphous calcium phosphate (CPP-ACP), derived from milk, is a stable calcium phosphorus remineralization system, which can be used in the minimally invasive treatment of early enamel caries, and has attracted much attention in recent years. In this paper, the structure of CPP-ACP, the mechanism of remineralization and related research progress are systematically reviewed and summarized, so as to provide reference for basic research and clinical application.


CPP-ACP. Caries, enamel demineralization, white spot lesions, Remineralization

Cite This Paper

Jing Wang, Yanli Mo, Yishan Liu. Research progress of CPP-ACP promoting enamel remineralization. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 9: 12-17. https://doi.org/10.25236/IJFM.2022.040903.


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