Yijing Cao, Wenjie Zhang, Suiyan Wei, Guoqiang Xu
The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
Oral lichen planus (OLP) is a relatively common chronic oral mucosal disease mediated by T cells, and its pathogenesis may include antigen-specific and non-specific. The etiology is unknown and the course of the disease is chronic and prolonged. The treatment has become a rather difficult clinical problem. There is no cure for OLP at present. Histologically, it is characterized by band-like infiltration of subepithelial T lymphocytes, rupture of the basement membrane, and liquefaction and degeneration of basal cells. Its etiology is not yet fully understood, its course is chronic, and its treatment has become a difficult clinical problem. Because of the malignant phenomenon of long-term erosion lesions, WHO lists it as a precancerous state. The main pathological changes of OLP are liquefaction and degeneration of basal cells and infiltration of subepithelial lymphocytes. The pathogenesis of OLP is not yet fully understood. OLP is an inflammatory disease mediated by T cells, which is related to autoimmune function. Various pathogenic factors lead to changes in the antigenicity of epithelial keratinocytes. The altered antigens are taken up by Langerhans cells and presented to T cells, these cells release and activate various cytokines to destroy the epithelium, and these cytokines activate T cells to initiate a series of immune responses, leading to the formation of OLP lesions. Studies have found that the pathogenesis of OLP is a process of immune damage mediated by T cells, which is related to the body's autoimmune function.
T cells, Oral lichen planus, New developments
Yijing Cao, Wenjie Zhang, Suiyan Wei, Guoqiang Xu. New Progress of T Cells in Oral Lichen Planus. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 10: 50-54. https://doi.org/10.25236/IJFM.2022.041008.
 Baghaei F, Shojaei S, Afshar-Moghaddam N, et al. Study of P21 Expression in Oral Lichen Planus and Oral Squamous Cell Carcinoma by Immunohistochemical Technique. J Dent (Shiraz). 2015; 16(3): 156-161.
 Xia Y , Huang J , Ming W , et al. Effect on the level of T cells immunity and mechanism of apoptosis in the Oral lichen planus patients induced by the total paeony glycoside[J]. Chongqing Medicine, 2015.
 Peng Q, Zhang J, Zhou G. Circulating exosomes regulate T-cell-mediated inflammatory response in oral lichen planus [J]. Journal of Oral Pathology & Medicine, 2019, 48(2).
 Rezazadeh F, Haghighat S. Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran [J]. BioMed Research International, 2021, 2021(7): 1-7.
 Gholizadeh N, Sadeghi A, Mirzaii-Dizgah I, et al. Serum level of estrogen in Iranian patients with oral lichen planus [J]. Asian Biomedicine, 2021, 15(3): 145-150.
 Lin Mei. Problems and discussion in clinical efficacy research of oral lichen planus [J]. Chinese Journal of Stomatology, 2005, 40(2): 3.
 Zhou Wei, Jin Yan, Wu Zhifen, et al. Analysis and significance of epithelial cell apoptosis in oral lichen planus [J]. Journal of Dental Pulp and Periodontology, 2001.
 Zhang N, Zhang J, Tan Y Q, et al. Activated Akt/mTOR-autophagy in local T cells of oral lichen planus [J]. International Immunopharmacology, 2017, 48: 84-90.
 Chaiyarit P, Luengtrakoon K, Wannakasemsuk W, et al. Biological functions of melatonin in relation to pathogenesis of oral lichen planus [J]. Medical Hypotheses, 2017, 104: 40.
 Peng Q, Zhang J, Ye X, et al. Tumor-like microenvironment in oral lichen planus: evidence of malignant transformation? [J]. Expert Review of Clinical Immunology, 2017: 635.
 None. Incidence of squamous cell carcinoma in oral lichen planus: A 25-year population-based study [J]. Journal of the American Academy of Dermatology, 2017, 76(6): AB413.
 Ruokonen H, Juurikivi A, Kauppila T, et al. High percentage of oral lichen planus and lichenoid lesion in oral squamous cell carcinomas [J]. Acta Odontologica Scandinavica, 2017: 1.
 Yuan H, Gong D, Cong S, et al. Dysbiosis of oral buccal mucosa microbiota in patients with oral lichen planus [J]. Oral Diseases, 2017, 23(5): 674.
 Polesello V, Zupin L, Lenarda R D, et al. DEFB1 polymorphisms and salivary hBD-1 concentration in Oral Lichen Planus patients and healthy subjects [J]. Archives of Oral Biology, 2017, 73: 161-165.
 Zhou Gang, Fan Mingwen. Clinical treatment of oral lichen planus [J]. Stomatological Research, 2004, 20(1): 3.
 Gong C, Sun S, Liu B, et al. Identification of potential therapeutic target genes, key miRNAs and mechanisms in oral lichen planus by bioinformatics analysis [J]. Archives of Oral Biology, 2017, 78: 122.
 Yang X Y, Zhang S N, Li X Z, et al. Analysis of human serum metabolome for potential biomarkers identification of erosive oral lichen planus [J]. Clinica Chimica Acta, 2017, 468: 46-50.
 Agha-Hosseini F, Imanpour M, Mirzaii-Dizgah I, et al. Mucin 5B in saliva and serum of patients with oral lichen planus [J]. Scientific Reports, 2017, 7(1): 12060.
 Fernandes D T, Santos-Silva A R, Vargas P A, et al. Development of proliferative verrucous leukoplakia (PVL) in oral lichen planus: Is it not a clinical spectrum of PVL? [J]. Medicina oral, patologia oral y cirugia bucal, 2017, 22(2): e142.
 Arash M, Najmeh S, Javad K S, et al. Increased salivary aldehyde dehydrogenase 1 in non-reticular oral lichen planus[J]. Anais Brasileiros De Dermatologia, 2017, 92(2):168-171.
 Raj T, Patil S. Diagnostic flaws in oral lichen planus and related lesions [J]. Oral Oncology, 2017, 74.
 Marshall A, Celentano A, Cirillo N, et al. Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus [J]. Journal of Oral Science, 2017, 59(3): 373-382.
 C A S A B, E Y H W D, C Y F C A B, et al. FoxP3 + CD4 +, IFN-γ + CD4 +, and IFN-γ + CD8 + cell levels in erosive and non-erosive types of oral lichen planus patients [J]. Journal of Dental Sciences, 2021, 16(2): 751-756.
 Shen Lijia, Ruan Ping, Xie Fangfang, et al. Expression and significance of Fas/FasL and granzyme B in oral lichen planus [J]. Journal of Southern Medical University, 2004, 024(012): 1362-1366.
 Ferrisse T M, Oliveira A, Palaon M P, et al. The role of CD68+ and CD163+ macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions [J]. Immunobiology, 2021, 226(5): 152072.
 Pourshahidi S, Sheykhbahaei N. Effectiveness of herbal based medications in treatment of oral lichen planus: A review article [J]. Journal of Herbal Medicine, 2021, 29(1): 100458.
 Ghazi N, Khorasanchi M. Markers associated with malignant transformation of oral lichen planus: A review article [J]. Archives of Oral Biology, 2021, 127(24): 105158.
 Lebioda Z, Dorocka-Bobkowska B. Low-level laser therapy in the treatment of recurrent aphthous stomatitis and oral lichen planus: a literature review [J]. Postepy Dermatologii I Alergologii, 2020, 37(4): 475-481.
 MD Petrillo, Stasio D D, Nevola R, et al. Clinical impact of direct-acting antiviral treatment on patients affected by hepatitis C virus-related oral lichen planus [J]. Journal of Hepatology, 2020, 73: S617.
 Wang X, Zhao Z, Tang N, et al. Corrigendum: Microbial Community Analysis of Saliva and Biopsies in Patients with Oral Lichen Planus [J]. Frontiers in Microbiology, 2020, 11: 1282.
 Zhang Shuilong, Xu Guoqi, Cao Hongkang, et al. Significance of Helicobacter pylori in the pathogenesis of oral lichen planus [J]. Journal of Clinical Stomatology, 1999, 15(4): 3.
 Val M, Gobbo M, Rossi M, et al. Answer to Photo Quiz White striae and erosions of the oral mucosa, but it is not oral lichen planus [J]. The Netherlands Journal of Medicine, 2020, 78(3): 147.
 Morrison L H, Moore J M. 18132 Hydroxychloroquine for refractory oral lichen planus [J]. Journal of the American Academy of Dermatology, 2020, 83(6): AB92.
 Jiang C, Wei W, Wang Y, et al. TRIM21 causes abnormal expression of IL-6 in oral lichen planus via the TRIB2-MAPK signal axis [J]. American Journal of Translational Research, 2020, 12(8): 4648-4658.
 Jariwala S, Googe P, Rajpal D, et al. 098 Comparative RNA-Seq profiling of oral lichen planus and mucous membrane pemphigoid patient samples reveal distinct and shared molecular pathways [J]. Journal of Investigative Dermatology, 2020, 140(7): S11.