Yun Jiayi1, Zhang Yuxin2, Zhao Fei1
1College of Integrated Traditional Chinese and Western Medicine, Hebei University of Traditional Chinese Medicine, Shijiazhuang, China
2College of Basic Medicine, Hebei University of Traditional Chinese Medicine, Shijiazhuang, China
IgA nephropathy is the most common autoimmune nephropathy which have high incidence rate and even appear renal failure. With the continuous development of network pharmacology, the characteristic with“Drug-active ingredient-disease” has been used in the treatment of IgA nephropathy. Making the characteristic which use TCM, the combination of TCM, medicine made of two or more ingredients to treatment IgA nephropathy in multi-component, multi-target, multi-pathway therapy and network pharmacology together. We found biological activity ingredient which can treat IgA nephropathy, that is quercetin, luteolin and kaempferol. They restrain producing inflammation cytokine which mainly inhibit PI3K/Akt and Akt through the synergistic action of the drug. They decrease immune complex’s sedimentation on lomerulus mesangial cell to reduce inflammation. The combine of TCM and network pharmacology open up a new idea which can remedy IgA nephropathy.
Network pharmacology; IgA nephropathy; Single herbal medicine; Herbal compounding
Yun Jiayi, Zhang Yuxin, Zhao Fei. Advances in network pharmacology-based Chinese medicine for the treatment of IgA nephropathy. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 11: 7-13. https://doi.org/10.25236/IJFM.2022.041102.
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