Meng Wang1, Xiaoping Cui2, Yating Zhang1, Panjie Cui1, Xinchun Xiao2, Xia Liu2
1Shaanxi University of Chinese Medicine, Xianyang, 712046, China
2Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712099, China
The incidence of vaginitis is high, and it is easy to relapse. The main clinical manifestations are leukorrhagia, vulva and vaginal itching. The treatment method and drug selection are especially important. In this paper, the relevant literature reports of topical drugs for treating vaginitis in recent years were searched, the pharmacological effects of commonly used western medicine, Chinese medicine and Chinese patent medicine were summarized, and the existing shortcomings were pointed out. It is helpful to provide the basis for clinical research of external drugs for vaginitis in the future.
Vaginitis, Topical Medications, Pharmacological Action, Research Progress
Meng Wang, Xiaoping Cui, Yating Zhang, Panjie Cui, Xinchun Xiao, Xia Liu. Research on Pharmacological Action of Commonly Used Topical Drugs for Vaginitis. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 11: 14-21. https://doi.org/10.25236/IJFM.2022.041103.
 Xu Congjian,Hua Keqin. Practice Of Obstetrics And Gynecology[M].Beijing:People's Medical Publishing House,2020:545-547.
 Luo Songping,Liu Yanfeng. Traditional Chinese Medicine Gynecology[M].People's Medical Publishing House,2019:148-154.
 Dong Fuxiang, Ding Xueying, Zheng Xiaoyan. Cost effect analysis of compound levofloxacin lactate vaginal suppositories and Lerison for the treatment of vaginitis[J]. Journal of Medical Forum. 2011,32(22):152+155.
 Zhu Xiao, Liu Xiaoxia, Lin Shuyun, et al. A multicenter, randomized, parallel, open phase IV clinical trial of clotrimazole vaginal suppositories and nifuratel mycin vaginal softgels in the treatment of mycovaginitis[J]. Electronic Journal of Clinical Medical Literature.2019,6(11):48-49+51.
 Gong Hui.Comparative observation of the clinical efficacy of metronidazole suppositories and metronidazole vaginal effervescent tablets in the treatment of vaginitis[J]. Heilongjiang Journal of Traditional Chinese Medicine.2021,50(04):23-24.
 Jia Weijing. Efficacy of ornidazole suppositories combined with clindamycin phosphate suppositories with ornidazole suppositories alone in the treatment of bacterial vaginitis[J].Chinese Journal of Clinical Rational Drug Use.2021,14(02):104-106.DOI:10.15887/j.cnki.13-1389/r.2021.02.044.
 Zheng Liqing,Zhang Li,Dong Xiaohua, et al. A Review on the Pharmacological Effects and Mechanisms of Osthole[J]. Acta Neuropharmacologica.2013,3(06):29-35.
 Sun Jiehui, Zuo Jin. The antipruritic effect of compound Kuh - seng Lotion and its influences to the expression of interleukin - 5 andinterleukin-10[J]. Gansu Medical Journal,2013,32(01):19-21.DOI:10.15975/j.cnki.gsyy.2013.01.005.
 Zhao Rui,Li Yanbing,Huang Ling. Experimental study of total base of bitter bean and four kinds of alkmonoids in vitro to kill Trichomonas vaginalis[J]. Journal of Sichuan of Traditional Chinese Medicine.2004(11):13-15.
Tao Zhi, Zhang Rui, Zhang Lei, et al. Effect of Sophora flavescens alkaloid on the growth of vaginal lactobacilli:an in vitro study.[J].Chinese Journal of Practical Gynecology and Obstetrics,2019,35(10):1137-1141.DOI:10.19538/j.fk2019100116.
 Jin Lingjia. Screening for Anti-Inflammation Component in Radix Stemona[J]. Chinese Medicine Modern Distance Education of China.2015,13(13):140-142.
 You Yeon Choi et al. The anti-inflammatory potential of Cortex Phellodendron in vivo and in vitro : Down-regulation of NO and iNOS through suppression of NF-κB and MAPK activation[J]. International Immunopharmacology, 2014, 19(2) : 214-220.
 Liu Chunping, Zhao Shuxiao, Chen Qiang, et al. Berberine hydrochloride anti-5 species of dermatophytes were experimentally observed [J]. Journal of Clinical Dermatology.2005(01):29.
 Zhao Xiangzhong,Dong Qun. Effect of DBYW with different dosage of cortex phellodendri（CP）on thymocyte apoptosis in autoimmune mice induced by CJ[J]. Journal of Wannan Medical College.2004(02):89-91.
 Xie Shenyang,Yang Xiaoyuan,Ding Zhanggui, et al. Chemical Constituents and Pharmacological Effects of Taraxacum mongolicum Hand-Mazz [J]. Natural Product Research and Development, 2012, 24(S1):141-151.DOI:10.16333/j.1001-6880.2012.s1.030.
 Quan Wurong, Xia Yan, Guan Xiaohui, et al. Anti-inflammatory effect sof Taraxacumsaponinon LPS-induced inflammation viaregulatingNF-kBpathway in Raw264.7 cells[J]. Agricultural Science Journal of Yanbian University,2019,41(02):41-48.DOI:10.13478/j.cnki.jasyu.2019.02.007.
 Yu Liheng. Research progress on the pharmacological effects of dandelion[J].Journal of Practical Traditional Chinese Medicine.2012,28(07):617-620.
 Huang Hanhui,Huang Leshan,He Zhiguang. The Effect of Dictam nus dasycarous on HA and 5-HT in acute inflammation tissues of rats[J]. Modern Hospitals.2008(10):31-33.
 Kim J H,Park Y M,Shin J S,et al.Fraxinellone inhibits lipopolysaccharide induced inducible nitric oxide synthaseand cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW264.7 macrophages cells[J].Biol Pharm Bull,2009,32(6):1062-1068.
 Han Xin,Wu Shijun,Gao Wenqi. Antimicrobial Activity of Volatile Oil from Peppers[J]. Food Science,2009,30(21):128-130.
 Zheng Jin, Zhang Lijuan. Research progress on the medicinal use of peppercorns[J]. Journal of Liaoning University of Traditional Chinese Medicine,2008(11):69-71.DOI:10.13194/j. jlunivtcm. 2008.11.71.zhengj.087.
 Huang Qiulan, Xue Nali, Fan Deping, et al. Research progress on anti-inflammatory pharmacological effects of Houttuynia cordata Thunb [J]. Hainan Medical Journal. 2019, 30(18): 2431-2433.
 Liang Minghui. Research of the chemical composition and pharmacological effects of Houttuynia cordata[J]. Guide of China Medicine,2019,17(02):153-154.DOI:10.15912/j.cnki.gocm.2019.02.132.
 Ma Li. Research of the pharmacological effects of honeysuckle [J]. Guangming Journal of Chinese Medicine. 2020,35(20):3308-3310.
 Zeng Anqi,Hua Hua,Chen Chaorong, et al. Comparative study onanti-inflammatory effect of Lonicerae Japonicae Flos and Lonicerae Flos[J]. China Journal of Chinese Materia Medica. 2020,45(16):3938-3944.DOI:10.19540/j.cnki.cjcmm.20200520.401.
 Chen Huiping. Treatment of 45 cases of mycotic vaginitis with Hongke Fujie Lotion[J]. Chinese Journal of Traditional Medical Science and Technology.2020,27(05):774-775.
 Li Yanxiang,Mei Long,Lu Zhaohui, et al. Anti-inflammatory,antipruritic and antibacterial effects of Honghefujie Lotion[J]. Northwest Pharmaceutical Journal,2015,30(03):260-264.