Frontiers in Sport Research, 2022, 4(7); doi: 10.25236/FSR.2022.040703.
College of Health Sciences, Hainan Vocational University of Science and Technology, Haikou, China
The aging of skeletal muscle is associated with the change of mitochondrial function. In increasingly aging society, exercise has been an important factor for health. Recent research showed that the decrease of proteins related to mitochondrial dynamics and the loss of skeletal muscle mass were only associated with protein OPA1. Aerobic exercise could increase the level of OPA1 in skeletal muscle, increase the amount of mitochondria and the secretion of cytokines in skeletal muscle, inhibit the generation of reactive oxygen species (ROS), thus regulate donwstream effectors, inhibit skeletal muscle atrophy and influence systemic metabolism and aging.
aerobic exercise, skeletal muscle, signing, mitochondrial dynamics
Zhenlei Lv. Advances in the Effects of Aerobic Exercise on Mitochondrial Function and Anti-aging of Muscles. Frontiers in Sport Research (2022) Vol. 4, Issue 7: 14-18. https://doi.org/10.25236/FSR.2022.040703.
 Demontis F, Piccirillo R, Goldberg A L, et al. The influence of skeletal muscle on systemic aging and lifespan[J]. Aging Cell, 2013, 12(6):943–949.
 Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, Simonsick EM, Tylavsky FA, Visser M, Newman AB. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci. 2006;61:1059–1064.
 Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, et al. Exercise effects on methylation of ASC gene. Int J Sports Med (2010) 31(09):671–5.10.1055/s-0029-1246140.
 Luo L, Lu A M, Wang Y, et al. Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats[J]. Experimental Gerontology, 2013, 48(4):427-436.
 Kim KH, Jeong YT.et al. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med. 2013 Jan; 19(1):83-92.
 Ibebunjo C, Chick J M, Kendall T, et al. Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia.[J]. Molecular & Cellular Biology, 2013, 33(2):194.
 Zhang L, He Z, Zhang Q, et al. Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats. International Journal of Molecular Sciences. 2014;15(3):4453-4463.
 Tezze, Caterina et al.Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass,Metabolic Homeostasis,Systemic Inflammation, and Epithelial Senescence.Cell Metabolism ,Volume 25 ,Issue 6, 2017 06,1374-1389.e6.
 FranceschiC.et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000 Jun; 908:244-54.
 Mesquita A, Weinberger M, Silva A, Sampaio-Marques B, Almeida B, Leão C, et al. Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity. Proc Natl Acad Sci U S A (2010) 107(34): 15123–8. 10. 1073 /pnas. 1004432107
 Ji L , Leeuwenburgh C, Leichtweis S, et al. Oxidative stress and aging. Role of exercise and its influences on antioxidant systems[J]. Annals of the New York Academy of Sciences, 1998, 854(1): 102–117.