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International Journal of Frontiers in Medicine, 2022, 4(11); doi: 10.25236/IJFM.2022.041105.

Research on the Effect of Exosomes on the Polarization of Macrophages


Sansan Li, Yindi Wang, Zhen Lv, Mingyu Zhang, Jianjun Wu, DongJin Ma

Corresponding Author:
Jianjun Wu

Public Health, Gansu University of Chinese Medicine, Lanzhou, China


Exosomes, as key tools of cellular communication, are involved in both physiological processes and pathological development of the organism.Macrophages are an important component of the body's intrinsic immunity and play an important role in the regulation of inflammation, maintenance of intra-tissue stability, and promotion of tissue repair and regeneration.Under the regulation of exosomal signaling, macrophages can polarize into M1-type pro-inflammatory and anti-tumor subtypes and M2-type anti-inflammatory and pro-tumor subtypes, which play a double-edged role in the development and progression of disease.This paper discusses the ways and pathways of exosomal micro-molecular long-stranded non-coding RNAs and miRNAs of different cellular origins affecting macrophage polarization and phenotype in three areas: tumor, neurological diseases, and cardiovascular diseases, aiming to provide new ideas and methods for research in this field.


Exosome, Tumor-associated Macrophages, Polarization

Cite This Paper

Sansan Li, Yindi Wang, Zhen Lv, Mingyu Zhang, Jianjun Wu, DongJin Ma. Research on the Effect of Exosomes on the Polarization of Macrophages. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 11: 31-36. https://doi.org/10.25236/IJFM.2022.041105.


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