International Journal of Frontiers in Medicine, 2022, 4(11); doi: 10.25236/IJFM.2022.041107.
Jiating Xu1, Lingli Zhang2, Odin van der Stelt2, Yiping Tang1, Chencheng Zhang2,3,4,5,6
1Department of Psychosomatic, Taizhou Second People’s Hospital, Taizhou, Zhejiang, China
2Emotion Helper, Shanghai, China
3Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
4Clinical Neuroscience Center, Ruijin Hospital Luwan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China
5Shanghai Research Center for Brain Science and Brain-Inspired Technology, Shanghai, China
6Ruijin-Mihoyo Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Deep brain stimulation (DBS) has emerged as a promising neurosurgical intervention for managing treatment-resistant depression (TRD). In this study, we conducted a literature review to evaluate the geographic distribution of published and ongoing clinical studies of DBS for TRD, along with documenting the anatomical sites used for electric stimulation in studies worldwide. The results showed large variation in the number of studies of DBS for TRD across different geographic regions and countries in the world, with research groups from North America and Europe contributing to 91% (n = 71) of all publications (N = 78) and 97% (n = 837) of all ongoing clinical trials (N = 867). Variation across countries also existed in the anatomical site used for stimulation, although the subcallosal cingulate gyrus was utilized most frequently overall (in 45 out of the 78 published studies), followed by the medial forebrain bundle and ventral capsule/ventral striatum including the nucleus accumbens. We conclude that DBS is increasingly being recognized worldwide as a promising intervention for TRD. To date, however, relatively few studies of DBS for TRD have been conducted by research groups from countries in Asia and Australasia. Clinical studies of DBS for TRD have come so far mainly from research groups located in North America and Europe, which poses a threat to the external validity of many reported study results, as well as representing a major challenge for future research.
Deep Brain Stimulation, Treatment-Resistant Depression, Therapy
Jiating Xu, Lingli Zhang, Odin van der Stelt, Yiping Tang, Chencheng Zhang. Current use of deep brain stimulation for treatment-resistant depression in different geographic regions of the world. International Journal of Frontiers in Medicine (2022), Vol. 4, Issue 11: 44-49. https://doi.org/10.25236/IJFM.2022.041107.
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