Welcome to Francis Academic Press

Academic Journal of Medicine & Health Sciences, 2023, 4(1); doi: 10.25236/AJMHS.2023.040102.

Progress of Chinese and Western medicine research on the treatment of functional dyspepsia based on intestinal microecology


Qiu Penghui1, Zhao Weihan2, Wu Jinyue1, Chen Chen1, Luo Xingyu1, Meng Ge1

Corresponding Author:
Zhao Weihan

1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

2Affiliated Hospital of Shaanxi University of Chinese Medicine, Shaanxi, 712000, China


Functional dyspepsia (FD) is a disease in which gastroparesis and diet-related symptoms are the main clinical manifestations due to the dysfunction of the gastroduodenum, but there are no structural changes and its pathogenesis is still unclear. In recent years, intestinal microecology has been confirmed to be related to FD. In this paper, we intend to review the role and mechanism of microecological agents and Chinese medicine in the treatment of functional dyspepsia, starting from the relationship between intestinal microecology and FD, in order to provide reference for clinical treatment and research.


intestinal microecology; intestinal flora; functional dyspepsia; microecological preparations; Chinese medicine

Cite This Paper

Qiu Penghui, Zhao Weihan, Wu Jinyue, Chen Chen, Luo Xingyu, Meng Ge. Progress of Chinese and Western medicine research on the treatment of functional dyspepsia based on intestinal microecology. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 1: 7-12. https://doi.org/10.25236/AJMHS.2023.040102.


[1] Francis P, Zavala SR. Functional Dyspepsia. 2021 Apr 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. PMID: 32119450.

[2] Sperber AD, Bangdiwala SI, Drossman DA, et al. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study. gastroenterology. 2021 Jan; 160(1): 99-114.

[3] Vandenberghe A, Schol J, Houte KVD ,et al. Current and emerging therapeutic options for the management of functional dyspepsia [J]. Expert Opin Pharmacother, 2020, 21(3):365-376.

[4] Enck P, Azpiroz F, Boeckxstaens G, et al. Functional dyspepsia [J]. Nature Rev Dis Primers, 2017, 3(5): 17081.

[5] Fu Yu, Shan Guoshun, Yin Aining, Ye Xueke, Yao Zhu. Research progress in the treatment of functional dyspepsia in Chinese and Western medicine[J]. Chinese Journal of Traditional Chinese Medicine, 2021, 39(10):82-85+270.

[6] Bäckhed F, Fraser CM, Ringel Y, et al. Defining a healthy human gut Microbiome: current concepts future directions, and clinical applications. Cell Host Microbe, 2012, 12(5): 611-22. 

[7] Markowiak P, Śliżewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017 Sep 15; 9(9):1021. 

[8] Qiu JJ, Liu Z, Zhao P, et al. Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model. World J Gastroenterol. 2017 Feb 7; 23(5):810-816. 

[9] Zhong L, Shanahan ER, Raj A, et al. Dyspepsia and the microbi- ome: time to focus on the small intestine [J]. Gut, 2017, 66(6): 1168 – 1169.

[10] Igarashi M, Nakae H, Matsuoka T, et al. Alteration in the gastric microbiota and its restoration by probiotics in patients with functional dyspepsia [J]. BMJ Open Gastroenterol, 2017, 4(1): e000144.

[11] Kim SK, Guevarra RB, Kim YT, et al. Role of Probiotics in Human Gut Microbiome-Associated Diseases. J Microbiol Biotechnol. 2019 Sep 28; 29(9):1335-1340.

[12] Barbara G, Feinle-Bisset C, Ghoshal UC,et al The Intestinal Microenvironment and Functional Gastrointestinal Disorders. Gastroenterology. 2016 Feb 18: S0016-5085(16)00219-5.

[13] Vanheel H, Vicario M, Vanuytsel T, et al. Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. gut. 2014 Feb;63(2):262-71.

[14] Gomi A, Yamaji K, Watanabe O, et al. Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: a double-blind, randomized,placebo-controlled study. J Dairy Sci 2018; 101:4830-41.

[15] Wauters L, Slaets H, De Paepe K, et al. Efficacy and safety of spore-forming probiotics in the treatment of functional dyspepsia: a pilot randomised, double-blind, placebo-controlled trial. Lancet Gastroenterol Hepatol. 2021 Oct; 6(10):784-792.

[16] Cai D.E. Clinical effects of Helicobacter pylori eradication quadruple therapy combined with probiotics in the treatment of Helicobacter pylori-positive functional dyspepsia [J]. Journal of Clinical Rational Drug Use, 2021, 14(22):81-83.

[17] Zhang J, Wu HM, Wang X, Xie J, et al. Efficacy of prebiotics and probiotics for functional dyspepsia: A systematic review and meta-analysis. Medicine (Baltimore). 2020 Feb; 99(7): e19107.

[18] SUN Er-Na, ZHANG Xiao-Mei, ZHAO Yi-Fan, MOTHER Zhi-Shen, SUN Jian, LUO Jie, WANG Ran. Digestion-promoting and intestinal flora-regulating effects of Lactobacillus paracasei LC-37 lactic acid beverage in humans[J]. Chinese Journal of Food, 2021, 21(10):95-100.

[19] GhouriYezaz A, RichardsDavid M, RahimiErik F, et al. Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease. Clin Exp Gastroenterol, 2014, 7: 473-487.

[20] Bindels LB, Delzenne NM, Cani PD, Walter J. Towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol 2015; 12: 303-310.

[21] Gibson GR, Probert HM, Van Loo J, Rastall RA, Roberfroid MB. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 2004; 17:259-75.

[22] Zhang S.S., Zhao L.Q. Expert consensus opinion on the diagnosis and treatment of functional dyspepsia in Chinese medicine (2017) [J]. Chinese Journal of Traditional Chinese Medicine, 2017, 32(06): 2595-2598.

[23] Wang LH, Wang FL, Li J, Zhang FW, Tian DL, Ding X. Ideas and countermeasures for the identification and treatment of functional dyspepsia in Chinese medicine[J]. Chinese Journal of Traditional Chinese Medicine, 2021, 36(09):5368-5371.

[24] Chen Y, Zhang B X, Yang X, Li Z, Yue R S. Exploring the theory of "stomach strength" in Chinese medicine based on intestinal flora in type 2 diabetes mellitus[J]. Liaoning Journal of Traditional Chinese Medicine, 2019, 46(05):975-976.

[25] Wan W, Li JX, Sun CM, et al. Progress of Chinese and Western medicine research based on intestinal microecology in the treatment of functional constipation[J]. World Science and Technology - Modernization of Chinese Medicine, 2020, 22(03):781-786.

[26] Wu G-L, Yu G-Y, Lu W-W. Current research on the regulatory effect of Chinese medicine compound on intestinal microecology[J]. Chinese Journal of Traditional Chinese Medicine, 2015, 40(18): 3534-3537.

[27] ZHANG X X, LI Z Y, MA Y L, et al. Progress in research of traditional Chinese medicine Citrus aurantium [J]. China J Chin Mater Med (Chinese Journal of Traditional Chinese Medicine), 2015, 40(2): 185-190.

[28] Wang T, Sun JY, Liu C, et al. Effects of bran-fried Citrus aurantium on intestinal flora of rats with functional dyspepsia[J]. Chinese Journal of Pharmacology, 2021, 56(13):1068-1075.

[29] Zheng M. S. Mechanistic study on the treatment of functional dyspepsia with six sacred herbs based on intestinal flora-immune modulation [D]. Central University for Nationalities, 2020.

[30] An X, Bao Q, Di S, et al. The interaction between the gut Microbiota and herbal medicines. Biomed Pharmacother. 2019 Oct; 118:109252.

[31] Huang Lihua. Mechanistic study of Si Jun Zi Tang on intestinal mucosa repair and glucose absorption in rats with spleen deficiency [D]. Guangdong University of Pharmaceutical Sciences,2016.

[32] Wu X., Zhou L., Luo X., et al. Effects of Sijunzi Tang polysaccharide on intestinal flora and immune function in mice with spleen deficiency[J]. Chinese Pharmacology and Clinical, 2014, 30(02): 12-14.

[33] Jiang H, Yang JM. Study on the effect of ginseng lingbaijusan on intestinal function of spleen-deficient mice and its mechanism[J]. Asia-Pacific Traditional Medicine, 2016, 12(07):16-17.

[34] Yang L, Song YY, Niu JH. Effect of ginseng and baijusan on intestinal flora in patients with ulcerative colitis[J]. Henan TCM, 2021, 41(09):1357-1361.

[35] Liang Kun, Fan Yanhao, Xu Yanwen, Yang Guizhen, An Hiei, Wang Xinhong. Interaction of Panxia diarrhea heart soup and different combinations with gastrointestinal bacteria[J]. Chinese Journal of Traditional Chinese Medicine, 2021, 36(10):5887-5893.

[36] Feng XZ, Zhang YN, Jiang X, Wang HG. Experimental study on the promotion of intestinal probiotic growth by adding flavor tonic Zhong Yi Qi Tang[J]. Chinese Journal of Microecology, 2008(02): 159-160.

[37] Zhao Chunyi, Xiao R, Yang Lingling, Li Yan, Zheng Liming, Zhang Jing. Exploring the efficacy of tonifying Zhong Yi Qi Tang in treating spleen deficiency type insomnia from the perspective of intestinal flora [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2020, 37(11):2057-2063.

[38] Hou T-S, Han X-X, Yang Y, Zhao J-L, Ren Y-D, Yu S-G, Wu Qiaofeng. Protective effect of electroacupuncture on intestinal microecology in rats with ulcerative colitis[J]. Acupuncture Research, 2014, 39(01):27-34.

[39] Wang Shudong, Cheng Zedong, Jindi, Chen Yiguo. Effect of gentle moxibustion of abdominal recruitment points on dysbiosis of intestinal flora in experimental rats[J]. Shanghai Journal of Acupuncture and Moxibustion, 2010, 29(08):546-548.

[40] Wang R. Study on the preventive effect of electroacupuncture pretreatment on atherosclerosis based on intestinal flora [D]. Liaoning University of Traditional Chinese Medicine, 2018.