Lujing Yu1,2, Guihong Huang3,4,5,6
1Lingui Clinical College, Guilin Medical University, Guilin, Guangxi, 541199, PR China
2College of Pharmacy, Guilin Medical University, Guilin, Guangxi, 541199, PR China
3Department of Pharmacy, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, PR China
4Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, PR China
5Guangxi Key Laboratory of Diabetic Systems Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541199, PR China
6Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, Guilin, Guangxi, 541199, PR China
Insulin resistance (IR) is a core mechanism leading to obesity and metabolic dysfunction of diabetes, and is the main cause of type 2 diabetes (T2DM). However, the etiology and mechanism of IR are very complex, which has not been clarified yet. Ferroptosis is a new type of iron dependent cell death, which is different from apoptosis, necrosis, autophagy and other typical cell death. It is not clear whether there is a direct relationship between Ferroptosis and IR. At present, only a few studies have explored the relationship between Ferroptosis and T2DM. The article starts from the mechanism of the two, reveals the possible relationship between them, so as to increase the understanding of IR and Ferroptosis, and hopes to lay a foundation for further clarifying the mechanism of insulin resistance.
Insulin resistance, Ferroptosis, Pathogenesis, Oxidative stress, Iron overload
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