Kang Yu1, Yang Zhihong2, Zhou Kaijun1, Zhou Yue1
1Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
2Department of Spleen and Gastroenterology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
Transient ischemic attack (TIA) belongs to the category of cerebrovascular disease stroke, is a subtype of ischemic cerebrovascular disease, stroke incidence is very high, and is also an important cause of population death. The occurrence of TIA has a great relationship with vascular abnormalities, the formation of vascular plaque makes the blood vessels hardening and narrowing, and then leads to the occurrence of transient cerebral ischemia.Modern studies have found that the abnormal lipid metabolism is closely related to the occurrence of TIA. Traditional Chinese medicine treats TIA from the "evil gas of phlegm and blood stasis". In combination, the "evil gas of phlegm and blood stasis" is related to the abnormal lipid metabolism, which also confirms that the drugs for reducing phlegm and blood stasis and turbidity can inhibit the metabolic factors of TIA and play a role in preventing and preventing the disease before it is diagnosed.Western medicine's targeted regulation of abnormal lipid metabolism and Chinese medicine's lipid-regulating and pulse-softening therapy may have certain modern research significance.
Transient ischemic attack, Lipid metabolism, Phlegm turbid.gore
Kang Yu, Yang Zhihong, Zhou Kaijun, Zhou Yue. Treating transient ischemic attack from the evil of Phlegm and blood stasis based on abnormal lipid metabolism. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 1: 51-55. https://doi.org/10.25236/AJMHS.2023.040109.
 Rothwell P M, Giles M F, Flossmann E, et al.A simple score(ABCD)to identify individuals at high early risk of stroke after transient ischaemic attack[J].Lancet,2005,366(9479):29-36.
 Li Qi, Zhong Jing. Risk factors analysis of acute ischemic stroke recurrence and the value of low density lipoprotein to high density lipoprotein ratio in predicting stroke recurrence [J].Chinese Journal of Circulation, 2014,29(9):694-697.
 Ma Yuping, Wang Zheng, Lu Xiaowei, et al.Clinical characteristics of transient ischemic attack/mild stroke in elderly and middle and low age [J].Chinese Journal of Neuroimmunology and Neurology, 2019,26(5):339-342.
 Peng Yuanyan, Qiu Chengbing, Zhou Min, et al.The Relationship between the level of Hcy, NSE and IL-8 and the recovery of neurological function in stroke patients [J].Journal of Molecular Diagnostics and Therapeutics, 2021,13(3):470-473.
 Chandratheva A, Lasserson D S, Geraghty O C, et al. Population-based study of behavior immediately after transient ischemic attack and minor stroke in 1000 consecutive patients:lessons for public education[J].Stroke, 2010,41(6):1108-1114.
 Yang Fang, Chen Yifei.Thinking on the treatment of metabolic syndrome from phlegm stasis [J]. Chinese Medical Frontiers, 2009,4(16):7-8. (in Chinese)
 Pan Y,Wangqin R,Li H,et alLDL-C levels, lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA [published online ahead of print, 2022 Mar 7].Stroke Vasc Neurol.2022;7 (4) : 276-284.
 WU X,ZHANG Y, WU Z, et al Plasma lipoprotein-associated phospholipase A2 level is an independent predictor of high thrombus burden in patients with acute st-segment elevation myocardial infarction[J].Int Heart J, 2016,57(6):689-696. (in Chinese)
 Arnold N, Koenig W. Atherosclerosis as an Inflammatory Disease-Pathophysiology,Clinical Relevance and Therapeutic Implications[J]. Dtsch Med Wochenschr,2019,144(5):315-321. (in Chinese)
 Li Haixia, Qi Xiangxing, Zhang Zushan.Expression levels of Lp-PLA2, hs-CRP and D-D in acute cerebral infarction patients with different NIHSS scores and their significance analysis [J].Journal of Integrated Traditional Chinese and Western Medicine, 2020, 18(11):1804-1807.
 Younus A,Humayun C,Ahmad R,et alLipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease:A systematic review.[J]. Clin Lipidol,2017,11:328-337.
 Li Yuechun, Liu Guorong, Lina et al.Study on the relationship between hyperhomocysteinemia and cerebrovascular disease [J].Chinese Journal of Neurology, 2000,33(6):373.
 Liu Hui, Zhong Qiang.Treatment of transient ischemic attack by combination of traditional Chinese and Western medicine: A report of 55 cases [J]. Shandong Journal of Traditional Chinese Medicine, 2006, 25 (1) :46-47. (in Chinese)
 Meng Shengxi, Huo Qingping, Wang Bing, et al.Treatment of ischemic cerebrovascular diseases from the perspective of phlegm stasis [J]. Shandong Journal of Traditional Chinese Medicine, 2015, 34(10): 733-735. (in Chinese)
 Zhu Min, Zhan Zengtu, Wang Meiping. Study on the correlation between TCM syndrome type distribution and blood lipid, carotid ultrasound signs and Hcy in ischemic stroke [J].World of Traditional Chinese Medicine, 2019,14(4):1046-1050.
 Ma Zhiheng, Shi Zhiqin, Zhang Hanxin, et al.Characteristics of TCM syndrome differentiation and its correlation with blood viscosity in patients with acute cerebral infarction in Chongming area [J].Chinese Journal of Experimental Formulae, 2012, 18(1):231-233.
 Zhang Daming.Hyperlipidemia belongs to "phlegm" belongs to "fat" change [J]. Modern Distance Education of Chinese Traditional Medicine,2008,6(5):401-402.
 Yang Li, Chen Xuezhong, Yin Fang, et al. Discussion of hyperlipidemia [J]. Clinical Journal of Traditional Chinese Medicine, 2005,17 (6): 539-540.
 Wang A,Tian X,Zuo Y,et al.Association between the triglyceride-glucose index and carotid plaque stability in nondiabetic adults[J].Nutr Metab Cardiovasc Dis,2021,31(10):2921-2928.
 Wu Y,Lu X,Zhang L, et al.Correlation between carotid intima-media roughness and cardiovascular risk factors[J].Exp Ther Med,2019,18(1):49-56.
 Li Chun, Huang Bo, Wei Chaoyang. Progress in the etiology of transient ischemic attack [J]. PLA Journal of Preventive Medicine, 2018,36 (02): 279-282.
 Peng Jing, Liu Ling, Chen Gang, et al. Effect of polyester sputum soup on blood lipid and oxidative stress index in MCI model rats [J]. Shizhen National Medicine, 2018,29 (3): 530-533.
 Wang Zuomei, Xiao Hongbin, Li Xueying, Yao Xinhui, Miao Jinjie, Cui Jinpeng, Li Shuzhou. Progress in the pharmacological effects of the decoction [J]. Modern Traditional Chinese Medicine, 2021, 41 (02): 22-28.
 Haixia Li, Shuyan Han, Xianwei Wang, Xu Ma, Ke Zhang, Li Wang, Zhizhong Ma, Pengfei Tu. Effect of the carthamins yellow from Carthamus tinctorius L.on hemorheological disorders of blood stasis in rats[J].Food and Chemical Toxicology,2009,47(8).