Yu Wang1,2, Sichen Duan1,2, Jiwen Geng1,2, Jia Liu1,2
1Department of Pediatric Dentistry, The First Affiliated Hospital of Xinjiang Medical University (Affiliated Dental Hospital), Urumqi, 830054, China
2Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, 830054, China
Dental caries is a common chronic oral disease that seriously affects people's health and quality of life, while patients with systemic diseases often neglect oral health due to systemic disease conditions, leading to the occurrence of oral problems, and some systemic diseases may promote or aggravate the development of oral problems, therefore, the awareness of oral health care of patients with systemic diseases should be raised, oral hygiene should be improved and quality of life should be enhanced. In this paper, the mechanism of the link between dental caries and systemic diseases and the preventive measures of oral diseases are discussed.
dental caries; systemic diseases; research progress
Yu Wang, Sichen Duan, Jiwen Geng, Jia Liu. Advances in the study of dental caries and systemic diseases. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 1: 88-93. https://doi.org/10.25236/IJFM.2023.050116.
 Mathur VP, Dhillon JK. Dental Caries: A Disease Which Needs Attention. Indian J Pediatr. 2018, 85(3): 202-206.
 Sabharwal A, Stellrecht E, Scannapieco FA. Associations between dental caries and systemic diseases: a scoping review. BMC Oral Health, 2021, 21(1):472.
 Yonekura S, Usui M, Murano S. Association between numbers of decayed teeth and HbA1c in Japanese patients with type 2 diabetes mellitus. Ups J Med Sci, 2017, 122(2):108-113.
 Ahmad R, Haque M. Oral Health Messiers: Diabetes Mellitus Relevance. Diabetes Metab Syndr Obes, 2021, 14:3001-3015.
 de Lima AKA, Amorim Dos Santos J, Stefani CM, et al. Diabetes mellitus and poor glycemic control increase the occurrence of coronal and root caries: a systematic review and meta-analysis. Clin Oral Investig, 2020, 24(11):3801-3812.
 Hintao J, Teanpaisan R, Chongsuvivatwong V, et al. The microbiological profiles of saliva, supragingival and subgingival plaque and dental caries in adults with and without type 2 diabetes mellitus. Oral Microbiol Immunol, 2007, 22(3):175-81.
 Nazir MA, AlGhamdi L, AlKadi M, et al. The burden of Diabetes, Its Oral Complications and Their Prevention and Management. Open Access Maced J Med Sci, 2018, 6(8):1545-1553.
 Chuang CJ, Hsu CW, Lu MC, et al. Increased risk of developing dental diseases in patients with primary Sjögren's syndrome-A secondary cohort analysis of population-based claims data. PLoS One, 2020, 15(9):e0239442.
 Berman N, Vivino F, Baker J, et al. Risk factors for caries development in primary Sjogren syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol, 2019, 128(2):117-122.
 Xin W, Leung KC, Lo EC, et al. A randomized, double-blind, placebo-controlled clinical trial of fluoride varnish in preventing dental caries of Sjögren's syndrome patients. BMC Oral Health, 2016, 16(1): 102.
 Hsu CY, Hung KC, Lin MS,et al. The effect of pilocarpine on dental caries in patients with primary Sjögren's syndrome: a database prospective cohort study. Arthritis Res Ther, 2019, 21(1):251.
 Ahmadi E, Fallahi S, Alaeddini M, Hasani Tabatabaei M. Severe dental caries as the first presenting clinical feature in primary Sjögren's syndrome. Caspian J Intern Med, 2013, 4(3):731-4.
 Piekoszewska-Ziętek P, Olczak-Kowalczyk D, Pańczyk-Tomaszewska M, et al. Developmental Abnormalities of Teeth in Children With Nephrotic Syndrome. Int Dent J, 2022, 72(4):572-577.
 Luong HM, Nguyen TT, Tran HT, et al. Oro-Dental Health and Primary Nephrotic Syndrome among Vietnamese Children. Children (Basel), 2021, 8(6):494.
 Kaczmarek U, Wrzyszcz-Kowalczyk A, Jankowska K, et al. Oral health conditions in children with idiopathic nephrotic syndrome: a cross-sectional study. BMC Oral Health, 2020, 20(1):213.
 Levi LE, Lalla RV. Dental Treatment Planning for the Patient with Oral Cancer. Dent Clin North Am, 2018, 62(1):121-130.
 Moore C, McLister C, Cardwell C, et al. Dental caries following radiotherapy for head and neck cancer: A systematic review. Oral Oncol. 2020, 100: 104484.
 Sroussi HY, Epstein JB, Bensadoun RJ,et al. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med, 2017, 6(12):2918-2931.
 Kawashita Y, Soutome S, Umeda M, et al. Oral management strategies for radiotherapy of head and neck cancer. Jpn Dent Sci Rev, 2020, 56(1):62-67.
 Doran AC. Inflammation Resolution: Implications for Atherosclerosis. Circ Res， 2022, 130(1): 130- 148.
 Wolf D, Ley K. Immunity and Inflammation in Atherosclerosis. Circ Res, 2019, 124(2):315-327.
 Chhibber-Goel J, Singhal V, Bhowmik D, et al. Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients. NPJ Biofilms Microbiomes, 2016, 2:7.
 Aarabi G, Heydecke G, Seedorf U. Roles of Oral Infections in the Pathomechanism of Atherosclerosis. Int J Mol Sci, 2018, 19(7):1978.
 Glodny B, Nasseri P, Crismani A,et al. The occurrence of dental caries is associated with atherosclerosis. Clinics (Sao Paulo), 2013, 68(7):946-53.
 Pussinen PJ, Paju S, Koponen J, et al. Association of Childhood Oral Infections With Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood. JAMA Netw Open, 2019, 2(4): e192523.
 Uerlich MF, Baker SR, Day PF, et al. Common Determinants of Dental Caries and Obesity in Children: A Multi-Ethnic Nested Birth Cohort Study in the United Kingdom. Int J Environ Res Public Health. 2021, 18(23):12561.
 Ravaghi V, Rezaee A, Pallan M, et al. Childhood obesity and dental caries: an ecological investigation of the shape and moderators of the association. BMC Oral Health, 2020, 20(1):338.
 Alshihri AA, Rogers HJ, Alqahtani MA, et al. Association between Dental Caries and Obesity in Children and Young People: A Narrative Review. Int J Dent, 2019, 2019:9105759.
 Cheng H, Chen R, Milosevic M, et al. Interventions Targeting Bottle and Formula Feeding in the Prevention and Treatment of Early Childhood Caries, Overweight and Obesity: An Integrative Review. Int J Environ Res Public Health, 2021, 18(23):12304.
 Agossa K, Roman L, Gosset M, et al. Periodontal and dental health in inflammatory bowel diseases: a systematic review. Expert Rev Gastroenterol Hepatol, 2021, 1-15.
 Elmaghrawy K, Hussey S, Moran GP. The Oral Microbiome in Pediatric IBD: A Source of Pathobionts or Biomarkers? Front Pediatr, 2021, 8: 620254.
 Zhang L, Gao X, Zhou J, et al. Increased risks of dental caries and periodontal disease in Chinese patients with inflammatory bowel disease. Int Dent J, 2020, 70(3):227-236.