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International Journal of Frontiers in Medicine, 2023, 5(3); doi: 10.25236/IJFM.2023.050303.

Association between diabetic kidney disease and low muscle mass in patients with type 2 diabetes: a cross-sectional study


Huang Qiuhong, Cheng Qingfeng, Zeng Qinglian, Ni Xia, Li Xun

Corresponding Author:
Huang Qiuhong

Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China


This study included 1241 inpatients with type 2 diabetes mellitus(T2DM) at the First Affiliated Hospital of Chongqing Medical University, China, from October 2013 to October 2018 to investigate the relationship between diabetic kidney disease and low muscle mass. The body composition of patients was measured with dual-energy X-ray-absorptiometry. Social history, medical history, and Clinical indexes were all collected to analyze. In the results, this study found: (1) The percentage of low muscle mass in the population with diabetic complications and cardiovascular and cerebrovascular diseases was far more than the diabetic patients without those; (2) Urinary albumin-to-creatinine ratio (UACR) in patients with low muscle mass was significantly higher than that observed in the cases without [23.3(5.80, 193.35) vs. 16.45(4.80, 76.73), P=0.01], and the prevalence of low muscle mass was positively correlated with stratified UACR (Cramer’s V=0.086, P for Cramer’s V=0.011); (3) Diabetic kidney disease was one of the independent risk factors for low muscle mass in patients with T2DM. [OR=1.64(1.05, 2.55), P=0.02].


Diabetes mellitus; Diabetic kidney disease; Low muscle mass; Urinary albumin-to-creatinine ratio; Sarcopenia

Cite This Paper

Huang Qiuhong, Cheng Qingfeng, Zeng Qinglian, Ni Xia, Li Xun. Association between diabetic kidney disease and low muscle mass in patients with type 2 diabetes: a cross-sectional study. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 3: 13-19. https://doi.org/10.25236/IJFM.2023.050303.


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