Periosteum is a vascularized connective tissue capsule covering the surface of bone tissue, which plays a decisive role in the process of bone reconstruction after bone defect. With the rapid development of the field of tissue engineering periosteum, its research direction is to synthesize bionic periosteum which can guarantee or accelerate the repair of bone defects. Artificial periosteum material can be similar to natural periosteum in structure and function and has good therapeutic potential. Electrospinning is an effective method to prepare biodegradable fiber membrane with porous microstructure, and it has a broad application prospect. The ideal bionic periosteum should have biocompatibility and bioactivity, appropriate surface chemical composition, good mechanical properties, and should simulate the natural extracellular matrix (ECM) of bone. Selecting the most suitable material to make bionic periosteum is an important step in the construction of bone tissue engineering. In this paper, the important role of tissue engineering periosteum is reviewed, and the electrospinning technology, including its preparation methods and the latest research progress of electrospinning polymer materials are introduced. Finally, the development prospects and challenges of tissue engineering periosteum based on electrospun nanofibers were summarized.

Suiyan Wei, Yijing Cao, Guoqiang Xu. Research progress of electrospinning bionic periosteum in bone tissue engineering. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 3: 51-56. https://doi.org/10.25236/IJFM.2023.050309.

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