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International Journal of Frontiers in Medicine, 2023, 5(3); doi: 10.25236/IJFM.2023.050314.

Iron accumulation in ferroptosis and the role of lipid peroxidation in osteoarthritis


Tinghe Shang1, Zhongcheng Gong2

Corresponding Author:
Zhongcheng Gong

1Oncological Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Xinjiang Medical University, School/Hospital of Stomatology Xinjiang Medical University, Urumqi, 830054, Xinjiang Uygur Autonomous Region, China

2Stomatological Research Institute of Xinjiang Uygur Autonomous Region, Urumqi, 830054, Xinjiang Uygur Autonomous Region, China


Ferroptosis is a recently discovered mode of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides, which can reach lethal levels, but this process was found to be inhibited by ferroptosis inhibitor-specific reverse. Osteoarthritis (OA) is the most common degenerative joint disease characterized by complex pathogenesis including mechanical overload, elevated levels of inflammatory mediators, metabolic alterations, and cellular senescence and death. Since iron accumulation and oxidative stress are common pathological features of OA, the role of ferroptosis in OA has been extensively explored. Accumulating evidence indicates that iron homeostasis and lipid peroxidation are closely related to the pathogenesis of OA. This article will focus on the mechanisms of ferroptosis and the role of iron homeostasis and lipid peroxidation in the pathogenesis of OA, summarizing recent evidence.


ferroptosis; iron accumulation; lipid peroxidation; osteoarthritis

Cite This Paper

Tinghe Shang, Zhongcheng Gong. Iron accumulation in ferroptosis and the role of lipid peroxidation in osteoarthritis. International Journal of Frontiers in Medicine (2023), Vol. 5, Issue 3: 77-82. https://doi.org/10.25236/IJFM.2023.050314.


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