Lung cancer is the number one malignant tumor disease in China in terms of death rate, and early stage patients can choose surgery for better prognosis. However, most patients usually lose the chance of surgery when they are diagnosed in the middle and late stages of the disease, with poor prognosis and poor quality of life. Based on the theory of five elements in Chinese medicine, nourishing the spleen and stomach can effectively enhance the physiological state of lung, which is the method of cultivating earth and generating gold. In the late stage of lung cancer, together with other treatments such as radiotherapy, targeted therapy and immunotherapy, it can relieve clinical symptoms, improve the quality of life and prolong the survival period.

Jing Lei, Hailong Si. The efficacy of earth cultivation and gold generation method in the treatment of middle and late stage lung cancer. Academic Journal of Medicine & Health Sciences (2023) Vol. 4, Issue 4: 33-38. https://doi.org/10.25236/AJMHS.2023.040406.

[1] Zheng Rongshou, Sun Kexin, Zhang Siwei, et al. Analysis of malignant tumor prevalence in China in 2015 [J]. Chinese Journal of Oncology, 2019, 41(1):19-28.

[2] Li Z. Tumor [M]. Beijing: People's Health Publishing House, 2001: 23.

[3] WONG S L, SUKKAR M B. The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease[J]. Br J Pharmacol, 2016, 174( 1) : 3-14.

[4] K NIGSHOFF M, KRAMER M, BALSARA N, et al. WNT1-inducible signaling protein – 1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis [J]. J Clin Invest, 2009, 119(4) : 772-787.

[5] Li RT. Summary of 40 cases of middle and late stage non-small cell lung cancer treated with Pei Tu Sheng Jin method[J]. Hunan Journal of Traditional Chinese Medicine,2009,25(05):1-2.

[6] Olmez I. Clinical outcomes in extracranial tumor sites and unusual toxieities with concurrent whole brain radiation (WBRT) and Erlotinib treatment in patients with non-small cell lung cancer (NSCLC) with brain metastasis. Lung Cancer, 2010, 70(2): 174-179.

[7] Preusser M, Capper D, Ilhan-Mutlu A, et al. Brain metastases: pathobiology and emerging targeted therapies. Acta Neuropathol, 2012, 123(2): 205-222.

[8] Barnholtz-Sloan JS, Sloan AE, Davis FG, et al. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol, 2004, 22(14): 2765-2772.

[9] Wang Y, Zhang W. Exploration on the effect of "Pei Tu Sheng Jin Method" on lung cancer chemotherapy in the middle and late stages to reduce toxicity and increase effectiveness[J]. Journal of Hubei University of Traditional Chinese Medicine, 2017, 19(01):54-57.

[10] Guo YM, Jiang Miao, Zheng G, et al. Analysis of Chinese medicine usage patterns in the treatment of lung cancer based on text mining technology [J]. Chinese Journal of Experimental Formulary, 2011, 17(16):277-280.

[11] Zhang Peitong, Yu Mingwei, Yang Zongyan, Li Dao-Rui, Liu Yong-Heng, Lin Hong-Sheng. Comparative study of Chinese and Western medicine efficacy evaluation methods for mid- to late-stage non-small cell lung cancer[J]. Chinese Journal of Integrative Medicine, 2010, 30(07):702-705.

[12] Chen Yu, Hu Kaiwen, He Mengke, Zhou Tian. Research progress of Yi-Qi method in the treatment of non-small cell lung cancer [J]. Acta Chinese Medicine, 2019, 34(9):1873-1879. 

[13] Zhou Zhou, Hou Wei, Wang Jiawei, et al. Exploration of individualized treatment of non-small cell lung cancer and the idea of evidence-based treatment [J]. Chinese medicine guide, 2017, 23(12): 34-37.

[14] Lin Yunhua, Qian Xiaoping. Research progress on the antitumor effects of Chinese herbal medicine Chonglou [J]. Medical Review, 2013, 19(13):2358-2360.

[15] Du YL, Wang ZM, Zhang SH. Efficacy of Pei Tu Sheng Jin method combined with chemotherapy in the treatment of non-small cell lung cancer[J]. Journal of Modern Traditional Chinese and Western Medicine, 2013, 22(30):3362-3364.

[16] Bu Xuhai. Clinical study of TP regimen chemotherapy with Pei Tu Sheng Jin formula for lung cancer [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2008, 10(12):88-89.

[17] Yang Qingle, Liu Huaimin. Exploration of treatment strategies for middle and late stage lung cancer and analysis of the advantages of Chinese medicine[J]. World Journal of Integrative Chinese and Western Medicine, 2016, 11(05):725-728.

[18] Chen C-F, Li C-Z, Liu S-X, Hou Jun, Wang J-M. Meta-analysis of the efficacy of Chinese medicine in the treatment of primary non-small cell lung cancer[J]. Journal of Traditional Chinese Medicine, 1999(05):287-289+5.

[19] Ye JZ, Tian Shaodan. An analysis of the application of the method of cultivating earth and generating gold in the treatment of lung cancer[J]. Journal of Practical Chinese Internal Medicine, 2005(05): 397-398.

[20] Zheng J, Pang D-Xiang. Self-designed Lung Jin-Sheng formula for the treatment of lung cancer [J]. Beijing Traditional Chinese Medicine, 2012, 9,31(9):666-668.