Objective: There has been increasing interest in the study of disc degeneration and degenerative disc disease. The purpose of this study was to investigate the global status and trends in this field. Methods: Retrieved 1991-2022 research papers related to disc degeneration and degenerative disc disease from the Science Citation Index-Expanded Web of Science. The source data were studied and indexed using bibliometrics. The visualization study used VOSviewer software to perform literature coupling, co-authorization, co-citation, and co-occurrence analysis to analyze trends in published research on disc degeneration and degenerative disc disease. Results: A total of 2036 literatures were included. Worldwide, the number of related research interests and publications is increasing every year. The United States contributes the most to global research, is cited the most and has the highest H-index. The journal Springer Nature published the most. The University of California, Rush University, Harvard University, Jefferson University and the University of Hong Kong are among the top contributors. Research can be divided into four categories: mechanism studies, animal studies, clinical trials, and tissue engineering. Mechanism research and tissue engineering are expected to be the next hot topics in this field. Conclusions: Judging from current global research trends, there will be an increasing number of papers on disc degeneration and degenerative disc disease. The United States is the largest contributor in this field. Much of the effort has been devoted to the mechanisms and tissue engineering of disc degeneration, such as nucleus pulposus cells and inflammatory responses, which may be the next hot spot in research.

Liao Changsheng, Wang Weiwei, Yang Su, Li Xiyong, Zheng Hongguang, Han Pengfei. Global trends in disc degeneration and degenerative disc disease: a bibliometric and visualization study. Frontiers in Medical Science Research (2023) Vol. 5, Issue 5: 11-19. https://doi.org/10.25236/FMSR.2023.050502.

[1] Kirnaz S, Capadona C, Wong T, et al. Fundamentals of Intervertebral Disc Degeneration. World Neurosurgery. 2022; 157:264-273. doi:10. 1016/j. wneu. 2021. 09. 066

[2] Kamali A, Ziadlou R, Lang G, et al. Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions. Theranostics. 2021; 11(1):27-47. doi:10. 7150/thno. 48987

[3] Ohnishi T, Iwasaki N, Sudo H. Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review. Cells. 2022; 11(3):394. doi:10. 3390/cells11030394

[4] Zhang G, Liu M, Chen H, et al. NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration. Cell Prolif. 2021; 54(7). doi:10. 1111/cpr. 13057

[5] Liao Z, Li S, Lu S, et al. Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration. Biomaterials. 2021; 274:120850. doi:10. 1016/j. biomaterials. 2021. 120850

[6] Cazzanelli P, Wuertz-Kozak K. MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology. IJMS. 2020; 21( 10):3601. doi:10. 3390/ijms21103601

[7] Fisher JN, Tessaro I, Bertocco T, Peretti GM, Mangiavini L. The Application of Stem Cells from Different Tissues to Cartilage Repair. Stem Cells International. 2017;2017:1- 14. doi:10. 1155/ 2017/ 2761678

[8] Xing D, Kwong J, Yang Z, et al. Intra-articular injection of mesenchymal stem cells in treating knee osteoarthritis: a systematic review of animal studies. Osteoarthritis and Cartilage. 2018; 26(4): 445-461. doi:10. 1016/j. joca. 2018. 01. 010

[9] Brandt JS, Hadaya O, Schuster M, Rosen T, Sauer MV, Ananth CV. A Bibliometric Analysis of Top-Cited Journal Articles in Obstetrics and Gynecology. JAMA Netw Open. 2019;2( 12):e1918007. doi: 10. 1001/jamanetworkopen. 2019. 18007

[10] Schober P, Vetter TR. Logistic Regression in Medical Research. Anesthesia & Analgesia. 2021; 132(2): 365-366. doi:10. 1213/ANE. 0000000000005247

[11] Synnestvedt MB, Chen C, Holmes JH. CiteSpace II: visualization and knowledge discovery in bibliographic databases. AMIA Annu Symp Proc. 2005; 2005:724-728. 

[12] Christodoulou E, Ma J, Collins GS, Steyerberg EW, Verbakel JY, Van Calster B. A systematic review shows no performance benefit of machine learning over logistic regression for clinical prediction models. Journal of Clinical Epidemiology. 2019;110:12-22. doi:10. 1016/ j. jclinepi. 2019. 02. 004

[13] Zhang Y, Han S, Kong M, Tu Q, Zhang L, Ma X. Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration. Osteoarthritis and Cartilage. 2021; 29(9):1324- 1334. doi:10. 1016/j. joca. 2021. 06. 010

[14] Vergroesen PPA, Kingma I, Emanuel KS, et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthritis and Cartilage. 2015;23(7):1057- 1070. doi:10. 1016/ j. joca. 2015. 03. 028

[15] Lindbäck Y, Tropp H, Enthoven P, Abbott A, Öberg B. PREPARE: presurgery physiotherapy for patients with degenerative lumbar spine disorder: a randomized controlled trial. The Spine Journal. 2018; 18(8):1347- 1355. doi:10. 1016/j. spinee. 2017. 12. 009

[16] Yurube T, Buchser WJ, Moon HJ, et al. Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study. Eur Spine J. 2019; 28(5):993- 1004. doi:10. 1007/s00586-019-05910-9

[17] Pfirrmann CWA, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration: Spine. 2001; 26( 17):1873- 1878. doi:10. 1097/00007632-200109010-00011

[18] Adams MA, Roughley PJ. What is Intervertebral Disc Degeneration, and What Causes It?: Spine. 2006; 31( 18):2151-2161. doi:10. 1097/01. brs. 0000231761. 73859. 2c

[19] Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol. 2014;10( 1):44-56. doi:10. 1038/nrrheum. 2013. 160

[20] Le Maitre C, Freemont AJ, Hoyland J. The role of interleukin- 1 in the pathogenesis of human Intervertebral disc degeneration. Arthritis Res Ther. 2005;7(4):R732. doi:10. 1186/ar1732

[21] Buckwalter JA. Aging and Degeneration of the Human Intervertebral Disc: Spine. 1995;20( 11):1307- 1314. doi:10. 1097/00007632- 199506000-00022

[22] Chu P, Wang T, Zheng J, et al. Global and Current Research Trends of Unilateral Biportal Endoscopy/Biportal Endoscopic Spinal Surgery in the Treatment of Lumbar Degenerative Diseases: A Bibliometric and Visualization Study. Orthopaedic Surgery. 2022;14(4):635-643. doi:10. 1111/os. 13216

[23] He Y, Li M, Yu H, et al. Bibliometric and altmetric analysis of research relating to antiphospholipid syndrome based on VOS viewer (2011–2021). Clin Rheumatol. Published online January 5, 2023. doi:10. 1007/s10067-022-06485-5

[24] Kirnaz S, Capadona C, Wong T, et al. Fundamentals of Intervertebral Disc Degeneration. World Neurosurgery. 2022; 157:264-273. doi:10. 1016/j. wneu. 2021. 09. 066

[25] Mern DS, Walsen T, Beierfuß A, Thomé C. Animal models of regenerative medicine for biological treatment approaches of degenerative disc diseases. Exp Biol Med (Maywood). 2021; 246(4): 483-512. doi:10. 1177/ 1535370220969123

[26] Zhai X, Wang Q, Li M. Tu Youyou’s Nobel Prize and the academic evaluation system in China. The Lancet. 2016; 387(10029):1722. doi:10. 1016/S0140-6736( 16)30261-6

[27] Tekari A, Marazza A, Crump K, Bermudez‐Lekerika P, Gantenbein B. Inhibition of the extracellular signal‐regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells. Journal Orthopaedic Research. 2022;40( 10):2362-2371. doi:10. 1002/jor. 25273

[28] Du K, He X, Deng J. MicroRNA- 16 inhibits the lipopolysaccharide-induced inflammatory response in nucleus pulposus cells of the intervertebral disc by targeting <I>TAB3</I>. Arch Med Sci. 2021; 17(2):500-513. doi:10. 5114/aoms. 2018. 74950

[29] She Y, Tang S, Zhu Z, et al. Comparison of temporomandibular joint disc, meniscus, and intervertebral disc in fundamental characteristics and tissue engineering. J Biomed Mater Res. 2023; 111(3):717-729. doi:10. 1002/jbm. b. 35178

[30] Gkantsinikoudis N, Kapetanakis S, Magras I, Tsiridis E, Kritis A. Tissue Engineering of Human Intervertebral Disc: A Concise Review. Tissue Engineering Part B: Reviews. 2022; 28(4): 848-860. doi:10. 1089/ten. teb. 2021. 0090