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Frontiers in Medical Science Research, 2023, 5(5); doi: 10.25236/FMSR.2023.050512.

Research progress on the angiogenic-osteogenic coupling signaling molecules of bone tissue engineering


Tiantian Zhu, Wuxikun Wuran, Xiayidan Aihemaitijiang, Huiyu He

Corresponding Author:
Huiyu He

Department of Prosthodontics, The First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, China


Angiogenesis and osteogenesis are integral to the process of bone growth, development, and repair and reconstruction. The close spatial and temporal association between osteogenesis and angiogenesis is known as "angiogenesis-osteogenesis coupling". Vascular invasion is a prerequisite for bone formation, and their mutual coupling is a key factor in bone formation. Vessels not only provide nutrients, transport oxygen, growth factors and metabolic wastes to bone tissue, but also regulate the various stages of angiogenesis and bone formation through vascular endothelial growth factor and angiopoietin. With the extensive research on tissue engineering in recent years, the role of signaling molecules related to angiogenesis-osteogenesis coupling in bone tissue engineering has been broadened. In this paper, we intend to review the relevant research results in order to provide ideas for tissue engineering bone vascularization.


growth factors; angiogenesis; osteogenesis; bone tissue engineering

Cite This Paper

Tiantian Zhu, Wuxikun Wuran, Xiayidan Aihemaitijiang, Huiyu He. Research progress on the angiogenic-osteogenic coupling signaling molecules of bone tissue engineering. Frontiers in Medical Science Research (2023) Vol. 5, Issue 5: 79-84. https://doi.org/10.25236/FMSR.2023.050512.


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