Frontiers in Medical Science Research, 2023, 5(5); doi: 10.25236/FMSR.2023.050514.
Yanan Zhou, Cong’e Tan
Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, China
Kidney Qi Pill is from Zhang Zhongjing's Jinkui Yaolve in the Han Dynasty, while Right Return Pill is from Zhang Jingyue's "JingYue QuanShu" in the Ming Dynasty, although the two sides were created in different dynasties, they are both kidney tonic formulas and are still used today. Drugs such as " three tonics " and "three diarrheas" and various drugs such as "less fire and more anger" in kidney qi pills can achieve tonify the kidney qi, while Right Return Pill is based on the Kidney-Qi Pill by deleting the "three tonics" and retaining the "three diarrhoeas". Both of them have the effect of warming the kidney yang, but Kidney Qi Pill aims to warm the kidney yang and transform the kidney qi, while Right Return Pill fills the kidney essence and helps the kidney yang. Its mechanism of action is the same and different, and at the same time, the "three tonics" are used to "seek yang in the yin", and the difference is the "three diarrhea" drugs and filling in the fine matching and trade-offs of the boutique. This paper aims to compare and analyze the characteristics of the combination of kidney qi pill and Right Return pill and modern molecular mechanism. In order to provide reference for the advantages of these two directions to study the drug and compatibility mechanism.
Kidney Qi Pill; Right Return Pill; Tonics and diarrhoea; Formulation and combination; Mechanism of action
Yanan Zhou, Cong’e Tan. Exploring the Combination Characteristics and Mechanism of Kidney Tonifying Effects of Kidney Qi Pill and Right Return Pill Based on the Theory of "Tonifying and Diarrhea". Frontiers in Medical Science Research (2023) Vol. 5, Issue 5: 94-98. https://doi.org/10.25236/FMSR.2023.050514.
[1] Liu Jintao, Li Menglin, Chen Zijie, et al. Analysis of the theory of reinforcing and reducing the bitter desire of five zang-organs in " Plain Questions · Zang-qi Method " [J].Chinese Journal of Traditional Chinese Medicine, 2019, 34 (07) : 2905-2908.
[2] Li Yuhang. The embodiment of the medication rule of ' five zang-organs bitter desire reinforcing and reducing ' in Zhongjing 's classical prescriptions-the medication example of ' five zang-organs and five flavor reinforcing and reducing ' in classical prescriptions [J].World Chinese Medicine, 2018,13 ( 02 ) : 295-308.
[3] Chen Qiuxia, Luo Baozhen. Study on the Evolution of the Naming of Zhongshenqi Pills in ' Jinkui Yuhan Yaolue Fang [J]. Western Chinese Medicine, 201831 (03): 49-52.
[4] An Dong, Liang Yonglin, Li Lu, et al. Effect of Yougui Pill and its disassembled prescriptions on energy metabolism of liver mitochondria in rats with kidney-yang deficiency [J].Chinese patent medicine, 2022, 44 (03) : 948-951.
[5] Zhang Zhao. Comparative study of the effects of Shenqi Pill and Yougui Pill on spermatogenic function and RAAS in rats with kidney-yang deficiency [D]. Shandong University of Traditional Chinese Medicine, 2010.
[6] Qin Yan, Zhu Jianguang. Research on the efficacy of Dihuang [J]. Chinese Medical Journal, 2018, 33 (01): 114-118.
[7] Xu Sili. Study on the molecular regulation mechanism of Yougui Pill on aging kidney-yang deficiency constitution [D].Chengdu University of Traditional Chinese Medicine, 2016.
[8] Cheng Yanran, Xiong Zhenfang, Hu Hui, etc. Application of Rehmannia glutinosa in Shenqi Pills [J]. Chinese Medicine Bulletin, 2018, 24 (16): 11-13.
[9] Geng Lianqi, Zhu Yan. Discussion on Jingui Shenqi Pill from ' Warming Kidney Yang ' to ' Tonifying Kidney Qi ' [J].Chinese Journal of Basic Medicine of Traditional Chinese Medicine, 2015,21 ( 10 ) : 1307-1308.
[10] Zhang Jiawei. Discussion on Mingmen Theory and Clinical Study of Jingui Shenqi Pill Syndrome [D]. Beijing University of Chinese Medicine, 2002.
[11] Tao Hanhua, Lv Cuixia, Zhang Suying, etc. Different kidney-tonifying mechanisms and characteristics of Shenqi Pill and Yougui Pill [J]. Journal of Shandong University of Traditional Chinese Medicine, 2009, 33 (05): 362-363.
[12] Wang Jiapeng, Sun Xiaojie. Effects of Rehmanniae Radix Praeparata on 6-hydroxydopamine- induced oxidative stress in dopaminergic neurons [J]. Chinese Journal of Gerontology, 2022, 42 (16): 4078-4082.
[13] Wang Jing, Ni Xinqiang, Li Limin, et al. To explore the effect of Rehmanniae Radix Praeparata on the energy metabolism of prefrontal cortex in rats with attention deficit hyperactivity disorder based on the theory of ' Yin Jing Yang impatient ' [J]. Chinese Journal of Traditional Chinese Medicine, 2022,47 (13) : 3554-3561.
[14] Yu H, Yao S, Zhou C, et al. Morroniside attenuates apoptosis and pyroptosis of chondrocytes and induces osteoarthritic development by inhibiting NF-κB signaling. J Ethnopharmacol. 2021 Feb 10; 266: 113447.
[15] Xing Chenchen, Zhang Xiaowei, Xu Jiangyan. Based on network pharmacology and molecular docking method, the mechanism of Rehmanniae Radix Praeparata-Corni Fructus in the treatment of diabetic kidney disease was analyzed [J].Chinese Medical Journal, 2022, 37 (07) : 1510-1517.
[16] Yin Xixi, Ma Zhengling, Tu Sijie, etc. To explore the mechanism of yam-rehmannia in the treatment of dementia based on network pharmacology [J]. Shanxi Traditional Chinese Medicine, 2022, 38 (03): 62-6.
[17] Liu Ming, Wang Huisen, Liang Ruifeng, et al. Study on the compatibility of Poria-Alisma and the effect of its standard decoction on nephropathy model rats [J].Chinese pharmacist, 2022,25 ( 08 ) : 1317-1323.
[18] Yan Zhangren, Pan Junqing, Hu Xiangjun, etc. Analysis of the mechanism of ' Fuling-Zexie ' in the treatment of prostatitis based on network pharmacology [J].Jiangxi Traditional Chinese Medicine, 2021,52 (05) : 58-62.
[19] Zhang Tong, Qin Yuewen, Wang Ping, et al. Screening and mechanism analysis of active components of Moutan Cortex in the treatment of chronic nephritis based on UHPLC-QTOF-MS / MS and TCMIP [J].Chinese herbal medicine, 2022,53 ( 09 ) : 2756-2767.
[20] Qiu Lin, Zhao Qunju, Dai Ziling, et al. Discussion on the compatibility mechanism of Shenqi Pill ' Shaohuo Shengqi ' based on mitochondrial energy metabolism [J].Shi Zhenguo Medicine, 2019,30 (08) : 1850-1853.
[21] Li Meihong. Shenqi Pill 'Shaohuo Shengqi 'compatibility on mitochondrial function of skeletal muscle in type 2 diabetic rats with yang deficiency syndrome [D]. Hunan University of Chinese Medicine, 2017.
[22] Wang Ruixia, Lian Fang, Sun Zhengao. From the perspective of modern reproductive medicine to explore the theory of ' kidney storing essence and dominating reproduction ' [J]. Liaoning Journal of Traditional Chinese Medicine, 2010, 37 (09): 1672-1674.
[23] Wang Jisheng, Deng Sheng, Wang Bin, et al. To explore the experimental study on the mechanism of Cuscuta chinensis-Lycii Fructus in improving oligoasthenospermia [J/OL].Chinese Journal of Traditional Chinese Medicine: 1-8 [2022-10-16].
[24] Hu Hailin. Experimental study on the effect of antler glue on the improvement of Yang deficiency oligoasthenospermia rats and the expression of CFTR protein [D].Hunan University of Traditional Chinese Medicine, 2021.
[25] Bi Xiaoying, Xu Ke, Zhao Yanxiao, et al. Based on the PI3K / AKT / mTOR pathway, the effects of total flavonoids of Eucommia ulmoides on sex hormone levels and ovarian tissue autophagy in rats with polycystic ovary syndrome were studied [J]. Pharmacology and clinical practice of traditional Chinese medicine, 2022,38 ( 01 ) : 82-86.