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Frontiers in Medical Science Research, 2023, 5(6); doi: 10.25236/FMSR.2023.050602.

Research Progress on Correlation between Gut Microbiome and Amyotrophic Lateral Sclerosis


Qiaozhen Wu, Qiang Wang, Jing Meng

Corresponding Author:
Qiang Wang

College of Acupuncture and Massage, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China


Amyotrophic Lateral Sclerosis (ALS), also known as motor neuron disease, is characterized by simultaneous degeneration of upper and lower motor neurons, resulting in muscle weakness, paralysis, and eventually death. However, research on its pathogenesis is currently unclear. Recently, many studies have found that the intestinal flora plays a direct or indirect role in the disease progression of ALS, including the release of neuroactive metabolites, increased intestinal permeability, and inducing metabolic disorders. Therefore, this article briefly reviews the correlation between intestinal microbiota and ALS in terms of pathology, aiming to provide new therapeutic targets for ALS.


Amyotrophic lateral sclerosis; Gut microbiome; Metabolism

Cite This Paper

Qiaozhen Wu, Qiang Wang, Jing Meng. Research Progress on Correlation between Gut Microbiome and Amyotrophic Lateral Sclerosis. Frontiers in Medical Science Research (2023) Vol. 5, Issue 6: 8-11. https://doi.org/10.25236/FMSR.2023.050602.


[1] Feldman EL, Goutman SA, Petri S, et al. Amyotrophic lateral sclerosis[J]. Lancet. 2022; 400(10360): 1363-1380. 

[2] Rossi S, Cozzolino M, CarrÌ MT. Old versus New Mechanisms in the Pathogenesis of ALS[J]. Brain Pathol. 2016; 26(2):276-286. 

[3] Zhang YG, Wu S, Yi J, et al. Target Intestinal Microbiota to Alleviate Disease Progression in Amyotrophic Lateral Sclerosis[J]. Clin Ther. 2017; 39(2):322-336. 

[4] Fang X, Wang X, Yang S, et al. Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing[J]. Front Microbiol. 2016; 7:1479. 

[5] Rowin J, Xia Y, Jung B, et al. Gut inflammation and dysbiosis in human motor neuron disease[J]. Physiol Rep. 2017; 5(18):e13443. 

[6] Gao K, Pi Y, Mu CL, et al. Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota-brain axis[J]. J Neurochem. 2019; 149(5):641-659. 

[7] Blacher E, Levy M, Tatirovsky E, et al. Microbiome-Modulated Metabolites at the Interface of Host Immunity [J]. J Immunol. 2017; 198(2):572-580. 

[8] Smith EF, Shaw PJ, De Vos KJ. The role of mitochondria in amyotrophic lateral sclerosis [J]. Neurosci Lett. 2019; 710:132933. 

[9] Blacher E, Bashiardes S, Shapiro H, et al. Potential roles of gut microbiome and metabolites in modulating ALS in mice[J]. Nature. 2019; 572(7770):474-480. 

[10] Sharma R, Young C, Neu J. Molecular modulation of intestinal epithelial barrier: contribution of microbiota [J]. J Biomed Biotechnol. 2010; 2010:305879. 

[11] Wu S, Yi J, Zhang YG, et al. Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model[J]. Physiol Rep. 2015; 3(4):e12356. 

[12] Dong L, Xie J, Wang Y, et al. Gut Microbiota and Immune Responses[J]. Adv Exp Med Biol. 2020; 1238: 165-193. 

[13] Sonnenburg JL, Bäckhed F. Diet-microbiota interactions as moderators of human metabolism [J]. Nature. 2016; 535(7610):56-64. 

[14] Ngo ST, Mi JD, Henderson RD, et al. Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions[J]. Degener Neurol Neuromuscul Dis. 2017; 7: 95-108. 

[15] Kocełak P, Zak-Gołąb A, Zahorska-Markiewicz B, et al. Resting energy expenditure and gut microbiota in obese and normal weight subjects[J]. Eur Rev Med Pharmacol Sci. 2013; 17(20): 2816-2821. 

[16] Lu G, Wen Q, Cui B, et al. Washed microbiota transplantation stopped the deterioration of amyotrophic lateral sclerosis: the first case report and narrative review[J]. J Biomed Res. 2022; 1-8. 

[17] Feng L, Zhang W, Shen Q, et al. Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome[J]. J Cachexia Sarcopenia Muscle. 2021; 12(6):1553-1569. 

[18] Gotkine M, Kviatcovsky D, Elinav E. Amyotrophic lateral sclerosis and intestinal microbiota-toward establishing cause and effect[J]. Gut Microbes. 2020; 11(6):1833-1841. 

[19] Zhao D, Simon JE, Wu Q. A critical review on grape polyphenols for neuroprotection: Strategies to enhance bioefficacy [J]. Crit Rev Food Sci Nutr. 2020; 60(4):597-625. 

[20] Frolinger T, Sims S, Smith C, et al. The gut microbiota composition affects dietary polyphenols-mediated cognitive resilience in mice by modulating the bioavailability of phenolic acids [J]. Sci Rep. 2019; 9(1):3546.